A5044414110- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Prostate Cancer Treatment and Research
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Dermatological and Skeletal Disorders
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- Birth, Development, and Health
- Cell Adhesion Molecules Research
- Pregnancy-related medical research
- Genetic factors in colorectal cancer
- Cynara cardunculus studies
- Glutathione Transferases and Polymorphisms
- Bone fractures and treatments
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
Universidade de São Paulo
2015-2024
Universidade de Ribeirão Preto
2008-2024
National Council for Scientific and Technological Development
2008-2024
Universidade Brasil
2022
Hôpital Arnaud de Villeneuve
2013
National University of Singapore
2013
National Cheng Kung University
2013
Centro de Reprodução Humana Prof. Franco Junior
2011
Clinics Hospital of Ribeirão Preto
2010
Universidade Federal de Uberlândia
2003-2008
Abstract Eutopic endometrium appears to be crucial for endometriosis development. Despite of the evident importance, data regarding cellular microenvironment remain unclear. Our objective was explore tissue heterogeneity, transcripts, and pathways that are enriched in all phases menstrual cycle by analysing publicly deposited derived from whole transcriptome microarrays eutopic endometria women with without endometriosis. A meta-analysis performed using raw available a public database....
We aim to investigate the expression of genes (MAPK1 and CAPN2) microRNAs (miR-30a-5p, miR-7-5p, miR-143-3p, miR-93-5p) involved in adhesion apoptosis pathways superficial peritoneal endometriosis (SE), deep infiltrating (DE), ovarian endometrioma (OE), evaluate whether these lesions share same pathophysiological mechanisms. used samples SE (n = 10), DE OE endometrial biopsies respective patients affected with under treatment at a tertiary University Hospital. Endometrial collected tubal...
Given the importance of menstrual blood in pathogenesis endometriosis and multifunctional roles mesenchymal stem cells (MenSCs) regenerative medicine, this issue has gained prominence scientific community. Moreover, recent reviews highlight how robust integrated assessment omics data are for endometriosis. To our knowledge, no study applied multi-omics approaches to MenSCs. This is a case-control at university-affiliated hospital. MenSCs transcriptome proteome were obtained by RNA-seq...
Menstrual blood mesenchymal stem cells (MenSCs) have gained prominence in the endometriosis scientific community, given their multifunctional roles regenerative medicine as a noninvasive source for future clinical applications. In addition, changes post-transcriptional regulation via miRNAs been explored endometriotic MenSCs with role modulating proliferation, angiogenesis, differentiation, stemness, self-renewal, and mesenchymal-epithelial transition process. this sense, homeostasis of...
Compared to healthy women, is the profile of transcripts altered in eutopic endometrium infertile women with endometriosis during implantation window (IW)?The seems be transcriptionally similar and fertile controls (FC) IW.Endometriosis a disease related infertility; nevertheless, little known regarding ethiopathogenic mechanisms underlying this association. Some studies evaluating patients suggest there an endometrial factor involved disease-related infertility. However, no study date has...
Endometriosis affects a significant proportion of women worldwide; however, no definitive cure for this disease has been discovered to date. Oxidative stress promotes endometriotic lesion maintenance in the peritoneal cavity women. Furthermore, there is evidence mitogen-activated protein kinase (MAPK) signaling pathway and senescence involvement physiopathogenesis endometriosis. Reactive oxygen species (ROS) cause oxidative damage are expected trigger endometrium while also causing...
Endometriosis causes immunological and cellular alterations. lesions have lower levels of lamin b1 than the endometrium. Moreover, high pro-inflammatory markers are observed in peritoneal fluid, follicular serum endometriosis lesions. Thus, we hypothesized that accumulation senescent cells tissues would facilitate maintenance an inflammatory microenvironment. To study cell senescence-associated secretory phenotype (SASP) lesions, conducted a cross-sectional with 27 patients undergoing video...
Abstract Endometriosis is a chronic inflammatory disorder that highly associated with infertility. This association seems to be related oocyte impairment, mainly in the initial stages of endometriosis (minimal and mild), where no distortions or adhesions are present. Nonetheless, invasive analyses not routinely feasible; thus, indirect assessment quality desirable, and, this context, cumulus cells (CCs) may more suitable targets analysis. CCs crucial development could used as an index...
Considerable effort has been invested in searching for less invasive methods of diagnosing endometriosis. Previous studies have indicated altered levels the CALD1 gene (encoding protein caldesmon) The aims our study were to investigate whether average expression and caldesmon are differentially endometrium endometriotic lesions evaluate performance as potential biomarkers Paired biopsies endometrial tissue (eutopic endometrium) (ectopic obtained from patients with endometriosis by real-time...
Given the importance of menstrual blood in pathogenesis endometriosis and multifunctional roles mesenchymal stem cells (MenSCs) regenerative medicine, this issue has gained prominence scientific community. Moreover, recent reviews highlight how robust integrated assessment omics data is for endometriosis. To our knowledge, no study applied multi-omics approaches to MenSCs. It a case-control at university-affiliated hospital. MenSCs transcriptome proteome were obtained by RNA-seq UHPLC-MS/MS...
Endometriosis is a complex and multifactorial disease. Chromosomal imbalance screening in endometriotic tissue can be used to detect hot-spot regions the search for possible genetic marker endometriosis. The objective of present study was chromosomal imbalances by comparative genomic hybridization (CGH) ectopic samples from ovarian endometriomas eutopic same patients. We evaluated 10 tissues endometrial metaphase CGH. CGH prepared with normal test DNA enzymatically digested, ligated adaptors...