A5034726506- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Reproductive Physiology in Livestock
- Immunodeficiency and Autoimmune Disorders
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Pharmacological Effects of Natural Compounds
- Systemic Lupus Erythematosus Research
- Mast cells and histamine
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Science and Education Research
- Circular RNAs in diseases
- Blood groups and transfusion
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Immune Response and Inflammation
- melanin and skin pigmentation
- Bone health and osteoporosis research
- Gynecological conditions and treatments
Universidade de São Paulo
2014-2023
Universidade de Ribeirão Preto
2010-2023
Clinics Hospital of Ribeirão Preto
2010
HLA-G molecule plays an important role on immune response regulation and has been implicated the inhibition of T natural killer cell cytolytic function allogeneic T-cell proliferation. Due to its immune-modulator properties, gene expression associated with outcome allograft autoimmune, infectious, malignant disorders. Several lines evidence indicate that polymorphisms at 5'-upstream regulatory region (5' URR) 3'-untranslated (3' UTR) may influence levels. Because Brazilians represent one...
The human leukocyte antigen-E (HLA-E) locus is a major histocompatibility complex (MHC) gene associated with immune-modulation and suppression of the immune response by interaction specific natural killer (NK) T cell receptors (TCRs). It considered one most conserved genes MHC; however, this low nucleotide variability seems to be consequence scarce number studies focusing on subject. In manuscript we assessed at HLA-E coding 3' untranslated regions (3'UTRs) in Brazil populations from...
The non‐classical human leukocyte antigen (HLA) class I genes present a very low rate of variation. So far, only 10 HLA‐E alleles encoding three proteins have been described, but two are frequently found in worldwide populations. Because its historical background, Brazilians suitable for population genetic studies. Therefore, 104 bone marrow donors from Brazil were evaluated exons 1–4. Seven variation sites found, including known single nucleotide polymorphisms (SNPs) at positions +424 and...
Human leukocyte antigen (HLA) haplotypes are frequently evaluated for population history inferences and association studies. However, the available typing techniques main HLA loci usually do not allow determination of allele phase constitution a haplotype, which may be obtained by very time-consuming expensive family-based segregation study. Without study, computational inference probabilistic models is necessary to obtain haplotypes. Several authors have used expectation-maximization (EM)...
Vitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies have discovered about 50 loci associated with disease, many immunological functions. Among them HLA-G, which modulates immunity by interacting specific inhibitory receptors, mainly LILRB1 and LILRB2. Here we investigated LILRB2 vitiligo risk evaluated possible role interactions between HLA-G its receptors in this pathogenesis. We tested polymorphisms LILRB1, using logistic regression along adjustment...
Endometriosis is a complex and multifactorial disease. Chromosomal imbalance screening in endometriotic tissue can be used to detect hot-spot regions the search for possible genetic marker endometriosis. The objective of present study was chromosomal imbalances by comparative genomic hybridization (CGH) ectopic samples from ovarian endometriomas eutopic same patients. We evaluated 10 tissues endometrial metaphase CGH. CGH prepared with normal test DNA enzymatically digested, ligated adaptors...
Human leukocyte antigen‐C (HLA‐C) is a classical HLA class I molecule that binds and presents peptides to cytotoxic T lymphocytes in the cell surface. HLA‐C has dual function because it also interacts with Killer‐cell immunoglobulin‐like receptors (KIR) expressed natural killer cells, modulating their activity. The structure diversity of regulatory regions, as well relationship among variants along locus , are poorly addressed, few population‐based studies explored variability entire gene...
Leukocyte immunoglobulin (Ig)-like receptors (LILR) LILRB1 and LILRB2 may play a pivotal role in maintaining self-tolerance modulating the immune response through interaction with classical nonclassical HLA molecules. Although both diversity natural selection patterns over genes have been extensively evaluated, little information is available concerning genetic signatures on LILRB1/2 regions. Therefore, we identified using next-generation sequencing population sample from São Paulo State,...
HLA-A is the second most polymorphic locus of human leucocyte antigen (HLA) complex encoding a key molecule for presentation and NK cell modulation. Many studies have evaluated variability in worldwide populations, focusing mainly on exons, but regulatory segments been poorly characterized. particularly high segment peptide-binding groove (exons 2 3), which related to function balancing selection these segments. Here we evaluate genetic diversity gene considering continuous encompassing...
We report a novel nonclassical class I HLA ‐E*01:06 allele observed in Brazilian individuals.
Here we report two new non‐classical class I HLA‐G alleles found in the Brazilian population.
(1) Background: Vitiligo is characterized by white patches on the skin caused loss of melanocyte activity or absence these cells. The available treatments minimize symptoms retarding process depigmentation re-pigmenting affected regions. New studies are required for a better comprehension mechanisms that trigger disease and development more efficient treatments. Studies have suggested an autoimmune feature vitiligo, based occurrence other diseases in vitiligo patients their relatives,...
Here, we report a novel non‐classical class I HLA‐E allele found in the Brazilian population.