A5001734489- Malaria Research and Control
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Complement system in diseases
- Child Nutrition and Water Access
- Reproductive System and Pregnancy
- Global Maternal and Child Health
- Prostate Cancer Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- French Urban and Social Studies
- Parasite Biology and Host Interactions
- Reproductive Physiology in Livestock
- Parasitic Diseases Research and Treatment
- Lysosomal Storage Disorders Research
- Prostate Cancer Treatment and Research
- Social Sciences and Governance
- Insect symbiosis and bacterial influences
- Drug Transport and Resistance Mechanisms
- Iron Metabolism and Disorders
- Pneumonia and Respiratory Infections
- Digital Imaging for Blood Diseases
- Glycosylation and Glycoproteins Research
- Advanced Radiotherapy Techniques
Mère et Enfant en Milieu Tropical
2016-2025
Institut de Recherche pour le Développement
2016-2025
Sorbonne Paris Cité
2013-2025
Université Paris Cité
2016-2025
Inserm
1995-2025
Centre Hospitalier Universitaire de Reims
2023
Université de Reims Champagne-Ardenne
2023
Stanford University
2023
Laboratory of Excellence GR-Ex
2022
Sorbonne Université
1995-2019
The final outcome of infection by Trypanosoma brucei gambiense, the main agent sleeping sickness, has always been considered as invariably fatal. While scarce and old reports have mentioned cases self-cure in untreated patients, these studies suffered from lack accurate diagnostic tools available at that time. Here, using most specific sensitive to date, we report on a long-term follow-up (15 years) cohort 50 human African trypanosomiasis (HAT) patients Ivory Coast among whom 11 refused...
Individuals living in malaria endemic areas generally harbour multiple parasite strains. Multiplicity of infection (MOI) can be an indicator immune status. However, whether this is good or bad for the development immunity to malaria, still a matter debate. This study aimed examine MOI asymptomatic children between two and ten years age relate it erythrocyte variants, clinical attacks, transmission levels other parasitological indexes. Study took place Niakhar area Senegal, where mesoendemic...
Studies with animal models have suggested the possibility of interactions between parasites during concurrent infections and raised question a similar phenomenon in humans. The present survey was undertaken to assess impact urinary schistosomiasis on susceptibility children malaria. It carried out Senegal September 2001 March 2002 among 523 3-15 years age. We tested association Plasmodium falciparum densities load Schistosoma haematobium egg excretion using linear mixed model because data...
Background. In areas of seasonal malaria transmission, long-term asymptomatic carriage Plasmodium falciparum throughout the dry season has been primarily studied in terms parasites, and clinical consequences persistent parasite are unknown. Methods. A prospective study was conducted Senegal, from 2001 through 2003 among 1356 children living where is endemic, with transmission occurring August December. Cross-sectional parasitological measurements detection active attacks were performed....
Background Antibodies, particularly cytophilic IgG subclasses, with specificity for asexual blood stage antigens of Plasmodium falciparum, are thought to play an important role in acquired immunity malaria. Evaluating such responses longitudinal sero-epidemiological field studies, allied increasing knowledge the immunological mechanisms associated anti-malarial protection, will help development malaria vaccines. Methods and Findings We conducted a 1-year follow-up study 305 Senegalese...
Background The association between placental malaria (PM) and first peripheral parasitaemias in early infancy was assessed Tori Bossito, a rural area of Benin with careful attention on transmission factors at an individual level. Methodology Statistical analysis performed 550 infants followed weekly from birth to 12 months. Malaria by anopheles human landing catches every 6 weeks 36 sampling houses season defined rainfall. Each child located GPS assigned the closest house. Data were analysed...
Abstract To determine the effect of maternal anaemia on pregnancy outcome and describe its impact infant haemoglobin level in first 18 months life, we conducted a prospective study 617 pregnant women their children Benin. Prevalence at delivery was 39.5%, 61.1% newborns were anaemic birth. Maternal not associated with low birth weight [OR = 1.2 (0.6–2.2)] or preterm 1.3 (0.7–2.4)], whereas newborn’s related to 1.8 (1.2–2.5)]. There no association between an infant’s until anaemia. However,...
Natural populations provide valuable information and resources for addressing the ge-netic characterization of biological systems. Botrytis cinerea is a necrotrophic fungus that exhibits complex responses to light. Physiological analysis B. from vineyards in Castilla y León (Spain) allowed identification isolate Bc116. This field shows reduced pathogenicity conditioned by light regime. Light also delays germination accentuates negative effect it exerts on vegetative growth cinerea. Bc116...
Plasmodium falciparum and Toxoplasma gondii are two apicomplexan parasites that can lead to severe complications for the newborn when contracted during pregnancy. This study explores cross-reactivity of antibodies specific both pathogens in pregnant women, exposed or not malaria. The antibody response against full-length recombinant antigens from P. (PfAMA1, Pfs48/45) T. (TgAMA1, TgSAG1, TgGRA7), selected their strong immunogenicity, was analysed on 150 plasma samples women residing Benin...
There is accumulating evidence for the involvement of genetic factors in human response to malaria infection, mostly based on results obtained studies severe clinical malaria. The role major gene(s) controlling blood parasitemia levels has also been detected by means segregation analysis. To confirm and localize such gene(s), we performed a sib-pair linkage analysis investigating five candidate chromosomal regions: 6p21 (HLA-tumor necrosis factor region), 2q13-q21 (genes coding interleukin-1...
Summary The aetiological diagnosis of human African trypanosomiasis (HAT) is based on the detection parasite, but currently available parasitological tests have low sensitivity and are hampered by fluctuating parasitaemia. identification seropositive individuals whom to focus examination antibody means Card Agglutination Trypanosomiasis Test (CATT/ T.b.gambiense ). A complicating phenomenon occurrence serologically positive parasitologically unconfirmed results (isolated CATT positivity)....
Malaria remains endemic in tropical areas, especially Africa. For the evaluation of new tools and to further our understanding host-parasite interactions, knowing environmental risk transmission—even at a very local scale—is essential. The aim this study was assess how malaria transmission is influenced can be predicted by climatic factors. As entomological part cohort 650 newborn babies nine villages Tori Bossito district Southern Benin between June 2007 February 2010, human landing catches...
Background. Several studies have shown that the risk of malaria infection increases for children born to a mother with placental infection. An immune tolerance phenomenon has been hypothesized. We addressed whether Plasmodium falciparum could additionally be associated nonmalaria fevers in infants. Methods. From 2007 2009, 553 infants were followed up from birth 18 months Benin. The occurrence fever was actively screened by trained community workers. Malaria (temperature >37.5°C positive...
Parasitic infections are associated with high morbidity and mortality in developing countries. Several studies focused on the influence of helminth malaria but nature biological interaction is under debate. Our objective was to undertake a study explore measure excreted egg load caused by Schistosoma haematobium Plasmodium falciparum parasite densities. Ten measures density two schistosomiasis urinary excretion over 2-year follow-up period 178 Senegalese children were considered. A linear...
Few tools are available to screen or assess infant's cognitive development, especially in French-speaking Africa. This study evaluated the use of French translation Mullen Scales Early Learning (MSEL), and "Ten Questions" questionnaire (TQ) 1-year-old children Benin, a francophone country.A cross-sectional was conducted 3 health centers serving semirural area Benin. Three hundred fifty-seven aged 12 months their mothers were enrolled 2011. Infant development assessed at local followed by...
Objectives Malaria infection of the placenta during pregnancy was found to be associated with infant susceptibility malaria. Other factors such as intensity malaria transmission and nutritional status child might also play a role, which has not been adequately taken into account in previous studies. The aim this study assess precisely parts played by environmental, biological determinants first infections, special interest role placental infection. objective paper is present final results...