A5039770382- Malaria Research and Control
- Pregnancy and preeclampsia studies
- Complement system in diseases
- Global Maternal and Child Health
- Mosquito-borne diseases and control
- Child Nutrition and Water Access
- Iron Metabolism and Disorders
- Reproductive System and Pregnancy
- Hemoglobinopathies and Related Disorders
- Parasites and Host Interactions
- Heavy Metal Exposure and Toxicity
- Research on Leishmaniasis Studies
- Hepatitis Viruses Studies and Epidemiology
- Blood Coagulation and Thrombosis Mechanisms
- Toxoplasma gondii Research Studies
- Neonatal and Maternal Infections
- Birth, Development, and Health
- Travel-related health issues
- vaccines and immunoinformatics approaches
- Neonatal Health and Biochemistry
- Sepsis Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Computational Drug Discovery Methods
Université Paris Cité
2016-2025
Mère et Enfant en Milieu Tropical
2016-2025
Institut de Recherche pour le Développement
2016-2025
Sorbonne Paris Cité
2014-2025
Institut du Développement Durable et des Relations Internationales
2018-2023
Laboratory of Excellence GR-Ex
2014-2022
Délégation Paris 5
2012-2022
Laboratoire Ville Mobilité Transport
2020
Université d'Abomey-Calavi
2012-2017
Institut de Recherche pour le Développement
2001-2015
<b>Objective: </b> To examine the association of plasma cholesterol levels, lipid-lowering agent (LLA) intake, and <i>APOE</i> genotype with dementia prevalence. <b>Methods: The Three-City Study is a population-based cohort 9,294 subjects selected from electoral rolls three French cities (Bordeaux, Dijon, Montpellier). Baseline examination included extensive assessment exposure to vascular risk factors (including levels LLA use [statin or fibrate]) clinical diagnosis dementia. <b>Results:...
Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique variant surface antigens are involved in the placental sequestration precipitates pregnancy-associated malaria (PAM). Two var gene subfamilies, var1csa and var2csa have been associated with CSA binding. We show here P. isolates highly transcribed but not var1csa. was or only minimally by isolated from nonpregnant women. Placental effectively bound proteoglycans higher levels of var2csa. In pregnant...
Molecular, as opposed to microscopic, detection measures the real prevalence of Plasmodium falciparum infections. Such occult infections are common during pregnancy but their impact on outcomes is unclear. We performed a longitudinal study describe that impact.In cohort 1037 Beninese pregnant women, we used ultrasound accurately estimate gestational ages. Infection with P. falciparum, hemoglobin concentration, use intermittent preventive treatment (IPTp) for malaria, and other parameters...
Although consequences of malaria in pregnancy are well known, the period which infection has highest impact is still unclear. In Benin, we followed up a cohort 1,037 women through until delivery. The objective was to evaluate relationship between timing and birth weight, maternal anemia at At beginning pregnancy, peripheral infections were associated with decrease mean weight (−98.5 g; P = 0.03) an increase risk delivery (adjusted odds ratio [aOR] 1.6; 0.03). Infections late related higher...
In areas endemic for malaria, pregnant women frequently present with a placenta that has been parasitized by Plasmodium falciparum, an infection associated reduction in the birth weight of offspring. However, impact placental on malaria-related morbidity during infant's first years life not investigated. Between 1993 and 1995, 197 children southern Cameroon were followed weekly clinically monthly parasltologically. The dates positive blood smear evolution parasite prevalence rates compared...
Otherwise clinically immune women in areas endemic for malaria are highly susceptible to Plasmodium falciparum during their first pregnancy. Pregnancy-associated (PAM) is characterized by placental accumulation of infected erythrocytes that adhere chondroitin sulfate A (CSA). Susceptibility PAM decreases with increasing parity, apparently due acquisition antibodies directed against the variant surface antigens (VSAs) mediate adhesion CSA (VSACSA). This study found levels VSACSA-specific...
BackgroundIn the context of increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated efficacy mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp) MethodsA multicenter, open-label equivalence trial was conducted in Benin from July 2005 through April 2008. Women all gravidities were randomized receive SP (1500 mg sulfadoxine and 75 pyrimethamine) or 15 mg/kg MQ a single intake twice pregnancy. The primary end point proportion low–birth-weight (LBW)...
Abstract Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to placental tissue. Binding mediated VAR2CSA, a parasite antigen coded the var gene, which interacts with chondroitin sulfate A (CSA). Consequences include maternal anemia and fetal growth retardation. Antibody-mediated immunity acquired during successive pregnancies, but target of VAR2CSA-specific protective antibodies unclear. We assessed in pregnant women analyzed their relationships protection...
Anemia during childhood remains a major public health challenge in sub-Saharan Africa. To determine the prevalence of and main risk factors for anemia young children, we conducted longitudinal survey Ebolowa southern Cameroon. Children were enrolled two cohorts followed three-year period: first cohort was composed 122 children from 0 to 36 months age second 84 24 60 age. The weekly symptomatic malaria, monthly both asymptomatic every six hematologic data; grouped into six-month groups....
During pregnancy, a local and systemic Th2 bias of maternal immunity favors Th1-dependent infections such as malaria. This study measured cytokines secreted in cultures chorionic villi, placental blood cells (PBC), serum term placentas from 88 malaria-infected -noninfected Cameroon women. Interleukin (IL)--2 --4 were consistently low; IL-1 beta, IL-6, granulocyte-macrophage colony-stimulating factor, transforming growth factor (TGF)--beta 2 highest villi cultures. Tumor necrosis...
Pregnancy-associated malaria (PAM) is precipitated by the accumulation of parasites in placental intervillous spaces and causes maternal anemia low birth weight. In PAM, adhere to chondroitin sulfate A (CSA) through a unique set variant surface antigens (VSAPAM). Several studies have shown that 1 var gene, var2csa, transcribed at high levels expressed CSA-binding Plasmodium falciparum parasites.Plasma anti-VAR2CSA immunoglobulin G (IgG) Senegalese women were measured during pregnancy...
Background Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based sequence homology PfEMP-1 variants have been grouped into three major groups A-C, conserved VAR2CSA variants, and semi-conserved types defined by tandem runs specific domains ("domain cassettes" (DC)). The type determines phenotype, associated with clinical outcome infection. Methods Parasite isolates from Beninese...
Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood liver-stage parasites. However, primaquine other cause dose-dependent haemolysis subjects G6PD deficiency, an X-linked disorder red cells that is very common populations living tropical subtropical areas. In order inform safer use Greater Mekong Subregion, a multi-centre study was carried out assess prevalence deficiency...
Abstract Background Post-Artesunate Delayed Hemolysis (PADH) occurs in 7-25% of adults with severe imported malaria. Whether it exists African children is controversial. Methods 351 treated artesunate were enrolled a prospective malaria study Benin. Clinical, epidemiological and biological data, plasma concentrations antimalarials captured or determined on admission then at 3, 5, 14, 21 28 days after starting treatment. PADH was defined by &gt;10% drop hemoglobin level and/or rise LDH...
There is accumulating evidence for the involvement of genetic factors in human response to malaria infection, mostly based on results obtained studies severe clinical malaria. The role major gene(s) controlling blood parasitemia levels has also been detected by means segregation analysis. To confirm and localize such gene(s), we performed a sib-pair linkage analysis investigating five candidate chromosomal regions: 6p21 (HLA-tumor necrosis factor region), 2q13-q21 (genes coding interleukin-1...
ABSTRACT In areas where Plasmodium falciparum is endemic, pregnant women are at increased risk for malaria, and this greatest during the first pregnancy. The placenta sequesters parasites that able to cytoadhere chondroitin sulfate A (CSA), a molecule expressed by placental syncytiotrophoblast, while from nonpregnant host do not bind CSA. Cytoadherence mediated expression of variants P. -erythrocyte membrane protein 1 family. Each member family induces antibodies specifically agglutinate...
Plasmodium falciparum-infected erythrocytes (IEs) adhere to host cell receptors, allowing parasites sequester into deep vascular beds of various organs. This defining phenomenon malaria pathogenesis is key the severe clinical complications associated with cerebral and placental malaria. The principal ligand binding chondroitin sulfate A (CSA) that allows sequestration IEs a P. falciparum erythrocyte membrane protein 1 (PfEMP1) family member encoded by var2csa gene.Here, we investigated...
Protection from infections in early life relies extensively on innate immunity, but it is unknown whether and how maternal modulate infants' immune responses, thereby altering susceptibility to infections. Plasmodium falciparum causes pregnancy-associated malaria (PAM), epidemiological studies have shown that PAM enhances infection with P. falciparum. We investigated PAM-mediated exposures utero affect responses their relationship infancy. In a prospective study of mothers babies Benin, we...
Background. Few studies have evaluated the effect of malaria on intrauterine growth restriction basis fetal rate, rather than just small-for-gestational age z score. Here, we assessed impact IUGR, using data from a longitudinal, ultrasonography-based follow-up study Beninese women. Methods. A total 1016 women were followed up gestational week 17 to delivery. Malaria was detected every month. Women underwent ultrasonography 4 times for determination and biometry. We birth...
ABSTRACT We performed ex vivo experiments with Plasmodium falciparum -infected human placentas from primi- and multigravida women Cameroon. All women, independent of their gravida status, had anti-chondroitin sulfate A (CSA) adhesion antibodies which cross-reacted heterologous strains, such as FCR3 Palo-Alto(FUP)1, were selected for CSA binding. These antibodies, directed against the surface infected erythrocytes obtained by flushing (IRBC ), restricted to immunoglobulin G3 isotypes. Massive...
Background. Pregnancy-associated malaria is characterized by selection and multiplication, in the placenta, of a distinct population Plasmodium falciparum expressing particular variant surface antigens (VSAs) that adhere to chondroitin sulfate A (CSA). Methods. The adhesion 40 freshly collected placental parasite isolates bovine CSA human low-sulfated proteoglycans (CSPGs) was investigated. Plasma samples from 30 pregnant women were used test, flow cytometry, their recognition...
T cell responses to leucoagglutinin, PPD, and seven Plasmodium falciparum blood stages antigens were investigated in 164 cord samples from Cameroonian neonates. In vitro measured by lymphocyte proliferation, IL‐2, IFN‐γ, IL‐4 release the presence of crude schizont extract, purified Pf155/RESA protein, synthetic peptides Pf155/RESA. Following culture leucoagglutinin or proliferation cytokine production very low, as compared adults same area. Interestingly, following stimulation lymphocytes...
In tropical countries, malaria and hypertension are common diseases of pregnancy. They have physiopathologic similarities such as placental ischemia, endothelial dysfunction, production proinflammatory cytokines. Recent findings suggested their possible link. The authors conducted a case-control study to explore the relation between at Guediawaye, hypoendemic malarial setting in Senegal. Cases were pregnant women admitted delivery unit for hypertension. Controls normal delivery, without any...