A5066821430- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Global Maternal and Child Health
- Dengue and Mosquito Control Research
- Insect symbiosis and bacterial influences
- Viral Infections and Outbreaks Research
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Migration, Identity, and Health
- Vector-Borne Animal Diseases
- Pregnancy and Medication Impact
- Maternal and Perinatal Health Interventions
- Complement system in diseases
- Healthcare Policy and Management
- Blood Coagulation and Thrombosis Mechanisms
- Emergency and Acute Care Studies
- HIV/AIDS Impact and Responses
- Healthcare Systems and Practices
- Reproductive Health and Contraception
- Child Nutrition and Water Access
- Fire effects on ecosystems
- Family and Patient Care in Intensive Care Units
- Research on Leishmaniasis Studies
Institut Pasteur de Dakar
2015-2025
Gynuity Health Projects
2020
Cheikh Anta Diop University
2014
Ministère De La Santé
2011
Institute of Health Research, Epidemiological Surveillance and Training
2004-2010
Espoir pour la Sante
2009
Centre National de la Recherche Scientifique
2006
Institut de Recherche pour le Développement
2006
Institut de Recherche pour le Développement
2004
Zika virus (ZIKV; genus Flavivirus, family Flaviviridae) is an emerging of medical importance maintained in a zoonotic cycle between arboreal Aedes spp. mosquitoes and nonhuman primates African Asian forests. Serological evidence isolations have demonstrated widespread distribution the Senegal. Several mosquito species been found naturally infected by ZIKV but little known about their vector competence. We assessed competence Ae. aegypti from Kedougou Dakar, unilineatus, vittatus...
Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique variant surface antigens are involved in the placental sequestration precipitates pregnancy-associated malaria (PAM). Two var gene subfamilies, var1csa and var2csa have been associated with CSA binding. We show here P. isolates highly transcribed but not var1csa. was or only minimally by isolated from nonpregnant women. Placental effectively bound proteoglycans higher levels of var2csa. In pregnant...
Aedes aegypti is the main epidemic vector of arboviruses in Africa. In Senegal, control activities are mainly limited to mitigation epidemics, with information available for Ae . populations. A better understanding current susceptibility status various insecticides and relevant resistance mechanisms involved needed implementation effective strategies. The present study focuses on detection insecticide reveals related populations from Senegal. Bioassays were performed adults nine Senegalese...
Abstract It is unclear whether West Nile virus (WNV) circulates between Africa and Europe, despite numerous studies supporting an African origin high transmission in Europe. We integrated genomic data with geographic observations phylogenetic phylogeographic inferences to uncover the spatial temporal viral dynamics of WNV these two continents. focused our analysis towards lineages 1 (L1) 2 (L2), most spatially widespread pathogenic lineages. Our study shows a Northern-Western L1,...
Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is a mosquito–borne, zoonotic pathogen. In Senegal, RVFV was first isolated in 1974 from Aedes dalzieli (Theobald) and thereafter Ae. fowleri (de Charmoy), ochraceus Theobald, vexans (Meigen), Culex poicilipes (Theobald), Mansonia africana Ma. uniformis (Theobald). However, the vector competence of these local species has never been demonstrated making hypothetical transmission cycle proposed for West Africa based on serological data...
Dengue fever (DEN) is the most common arboviral disease in world and dengue virus (DENV) causes 390 million annual infections around world, of which 240 are inapparent 96 symptomatic. During past decade a changing epidemiological pattern has been observed Africa, with DEN outbreaks reported all regions. In Senegal, DENV serotypes have reported. These important changes profile occurring context where there no qualified vaccine against DEN. Further significant gap knowledge on vector bionomics...
Background. Pregnancy-associated malaria is characterized by selection and multiplication, in the placenta, of a distinct population Plasmodium falciparum expressing particular variant surface antigens (VSAs) that adhere to chondroitin sulfate A (CSA). Methods. The adhesion 40 freshly collected placental parasite isolates bovine CSA human low-sulfated proteoglycans (CSPGs) was investigated. Plasma samples from 30 pregnant women were used test, flow cytometry, their recognition...
In tropical countries, malaria and hypertension are common diseases of pregnancy. They have physiopathologic similarities such as placental ischemia, endothelial dysfunction, production proinflammatory cytokines. Recent findings suggested their possible link. The authors conducted a case-control study to explore the relation between at Guediawaye, hypoendemic malarial setting in Senegal. Cases were pregnant women admitted delivery unit for hypertension. Controls normal delivery, without any...
Pregnancy-associated malaria (PAM) causing maternal anemia and low birth weight is among the multiple manifestations of Plasmodium falciparum malaria. Infected erythrocytes (iEs) can acquire various adhesive properties that mediate clinical severity Recent advances on molecular basis virulence immune evasion have helped identify var2csa as a PAM-specific var gene.The present study presents genome-wide microarray transcript analysis 18 P. parasite isolates freshly collected from placenta. The...
Abstract Background In low-resource settings, where abortion is highly restricted and self-induced abortions are common, access to post-abortion care (PAC) services, especially treatment of incomplete terminations, a priority. Standard has involved surgical intervention but can be hard in these areas. Misoprostol provides an alternative that could increase care. We sought gather additional evidence regarding the efficacy 400 mcg sublingual misoprostol vs. standard for environments need...
To assess the effectiveness of introducing condom-catheter uterine balloon tamponade (UBT) for postpartum haemorrhage (PPH) management in low- and middle-income settings.Stepped wedge, cluster-randomised trial.Eighteen secondary-level hospitals Uganda, Egypt Senegal.Women with vaginal delivery from October 2016 to March 2018.Use UBT PPH was introduced using a half-day training provision pre-packaged kits. Hospitals were randomised when introduced. The incident rate (IR) study outcomes...
Yellow fever virus remains a major threat in low resource countries South America and Africa despite the existence of an effective vaccine. In Senegal particularly eastern part country, periodic sylvatic circulation has been demonstrated with varying degrees impact on populations perpetual renewal. We report outbreak that occurred from October 2020 to February 2021 Senegal, notified managed through synergistic effort yellow national surveillance implemented by Senegalese Ministry Health...
Crimean-Congo hemorrhagic fever virus (CCHFV) is widespread in Asia, Europe, and Africa. In Senegal, sporadic cases of CCHFV have been reported since 1960. Bordering Mauritania northeastern Agnam an arid area the region Matam where endemic, which harbors a pastoralist community. Given drought conditions Agnam, inhabitants are constant movement with their animals search pasture, brings them into contact pathogens such as arboviruses. To identify this area, we established One Health site order...
Maternal and perinatal mortality are major problems for which progress in sub-Saharan Africa has been inadequate, even though childbirth services available, the poorest countries. Reducing them is aim of two main Millennium Development Goals. Many initiatives have undertaken to remedy this situation, such as Advances Labour Risk Management (ALARM) International Program, whose purpose improve quality obstetric low-income However, few interventions evaluated, context, using rigorous methods...
Mosquitoes are vectors of arboviruses affecting animal and human health. Arboviruses circulate primarily within an enzootic cycle recurrent spillovers contribute to the emergence human-adapted viruses able initiate urban involving anthropophilic mosquitoes. The increasing volume travel trade offers multiple opportunities for arbovirus introduction in new regions. This scenario has been exemplified recently with Zika pandemic. To incriminate a mosquito as vector pathogen, several criteria...
Abstract In 2020, a sylvatic dengue virus serotype 2 infection outbreak resulted in 59 confirmed cases Kedougou, Senegal, suggesting those strains might not require adaptation to reemerge into urban transmission cycles. Large-scale genomic surveillance and updated molecular diagnostic tools are needed effectively prevent infections Senegal.
Objective To evaluate, with volunteer professionals in a resource‐poor setting, an approach of audit and feedback to promote local implementation emergency obstetric guidelines. Design Triple cohort observational time series study. Setting A 46‐bed unit academic‐affiliated community hospital Senegal. Population All pregnant women haemorrhagic hypertensive complications who were admitted the maternity during study periods. Methods assess benefits guidelines implementation, maternal outcomes...
The mosquito-borne disease caused by the Rift Valley Fever Virus (RVFV) is a viral hemorrhagic fever that affects humans and animals. In 1987, RVFV emerged in Mauritania, which first outbreak West Africa. This was shortly followed reported cases livestock Senegal. Animal trade practices with neighboring Mauritania suggest northern regions of Senegal are at high risk for RVF. this study, we aim to conduct molecular serological survey Agnam (northeastern Senegal) RT-PCR (reverse transcription...
Crimean-Congo haemorrhagic fever virus (CCHFV) occurs sporadically in Senegal, with a few human cases each year. This active circulation of CCHFV motivated this study which investigated different localities Senegal to determine the diversity tick species, infestation rates livestock and infections CCHFV. The samples were collected July 2021 from cattle, sheep goats locations Senegal. Tick identified pooled by species sex for detection via RT-PCR. A total 6135 ticks belonging 11 4 genera...