Maurício Lacerda Nogueira
A5077050057- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Insect symbiosis and bacterial influences
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- SARS-CoV-2 detection and testing
- Cytomegalovirus and herpesvirus research
- Zoonotic diseases and public health
- Respiratory viral infections research
- Vector-Borne Animal Diseases
- Plant Virus Research Studies
- Animal Virus Infections Studies
- Vaccine Coverage and Hesitancy
- Poxvirus research and outbreaks
- HIV Research and Treatment
- Vector-borne infectious diseases
- Global Maternal and Child Health
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
Faculdade de Medicina de São José do Rio Preto
2016-2025
The University of Texas Medical Branch at Galveston
2013-2025
Hospital de Base
2007-2024
Galveston College
2023-2024
Brazilian Biosciences National Laboratory
2023-2024
Brazilian Center for Research in Energy and Materials
2023-2024
Secretaria da Saúde
2024
Hospital de Base
2014-2024
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2023-2024
Universidade do Estado do Pará
2024
Taking CRISPR technology further techniques are allowing the development of technologies for nucleic acid detection (see Perspective by Chertow). advantages distinctive enzymatic properties enzymes, Gootenberg et al. developed an improved multiplexed quantitative and highly sensitive detection, combined with lateral flow visual readout. Myhrvold added a sample preparation protocol to create field-deployable viral diagnostic platform rapid specific strains pathogens in clinical samples....
<h3>Importance</h3> There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the effect of chloroquine diphosphate (CQ) requires a high concentration drug. <h3>Objective</h3> To evaluate safety and efficacy 2 CQ dosages in patients with severe COVID-19. <h3>Design, Setting, Participants</h3> This parallel, double-masked, randomized, phase IIb clinical trial 81 adult who were hospitalized acute respiratory syndrome (SARS-CoV-2)...
Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in world. Because limited available data, assessments impact nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced reproduction number from >3 to 1 1.6 São Paulo and Rio de Janeiro. Sequencing 427 new genomes analysis geographically representative genomic dataset identified >100...
Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating inflammatory response, mainly lungs, triggered by severe acute respiratory syndrome 2 (SARS-CoV-2). This study aimed to evaluate efficacy methylprednisolone (MP) among hospitalized patients with suspected COVID-19.A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed aged ≥18 years clinical, epidemiological, and/or radiological COVID-19 at...
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort 1453 urban residents Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated 73% individuals were infected during 2015 outbreak. Attack spatially heterogeneous, varying by factor 3 within community...
Background: Vaccines are urgently needed to tackle the unprecedented morbidity and mortality of COVID-19. Administration inactivated viruses common mature platform developing new vaccines. CoronaVac is an vaccine that has undergone preclinical tests phase I/II clinical trials.Methods: We conducted a randomised, double-blind, placebo-controlled 3 trial with among healthy healthcare professionals in 16 centres Brazil. Participants received two doses (3 μg 0.5 mL) or placebo at day 0 14. The...
A low-cost, equipment-free rapid antigen test distinguishes dengue virus serotypes and Zika in patient sera without detectable cross-reactivity.
Abstract The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre the pandemic. SARS-CoV-2 established sustained transmission early pandemic, but important gaps remain our understanding virus dynamics at a national scale. We use 17,135 near-complete genomes sampled from 27 Brazilian states bordering country Paraguay. From March to November 2020, we detected co-circulation multiple viral lineages that were linked importations (predominantly Europe). After...
BackgroundButantan–Dengue Vaccine (Butantan-DV) is an investigational, single-dose, live, attenuated, tetravalent vaccine against dengue disease, but data on its overall efficacy are needed.MethodsIn ongoing phase 3, double-blind trial in Brazil, we randomly assigned participants to receive Butantan-DV or placebo, with stratification according age (2 6 years, 7 17 and 18 59 years); 5 years of follow-up planned. The objectives the were evaluate symptomatic, virologically confirmed any...
Summary Background There is no specific antiviral therapy recommended for the disease caused by SARS-CoV-2 (COVID-19). Recent publications have drawn attention to possible benefit of chloroquine (CQ). Our study aimed comprehensively evaluate safety and efficacy two different CQ dosages in patients with established severe COVID-19. Methods We performed a parallel, double-blinded, randomized, phase IIb clinical trial, aiming assess as adjunctive hospitalized SARS Manaus, Brazilian Amazon....
Zika virus (ZIKV) has been associated to central nervous system (CNS) harm, and was detected in the brain cerebrospinal fluids of microcephaly meningoencephalitis cases. However, mechanism by which reaches CNS is unclear. Here, we addressed effects ZIKV replication human microvascular endothelial cells (HBMECs), as an vitro model blood barrier (BBB), evaluated extravasation BBB integrity a vivo mouse experimental model. HBMECs were productively infected African Brazilian strains (ZIKVMR766...
The pathogenesis of severe dengue disease involves immune components as biomarkers. mechanism by which some virus (DENV)–infected individuals progress to is poorly understood. Most studies on the focus process antibody-dependent enhancement (ADE) a primary risk factor. With circulation Zika (ZIKV) in DENV-endemic areas, many people infected ZIKV were likely exposed DENV. influence such exposure outcomes remains unknown. We investigated whether patients previously DENV exhibited higher...
Public health concerns exist surrounding the epidemic of Zika virus (ZIKV) and rapid growth transplantation in developing countries, including endemic zones active arbovirus transmission, as well travel to such regions by potential organ donors recipients. Few data regarding clinical characteristics ZIKV infection immunocompromised hosts. Laboratory screening protocols for differentiate infections from other viral diseases detection possible donor-derived have not been stated. The diagnosis...
Abstract In Africa, Old World Primates are involved in the maintenance of sylvatic circulation ZIKV. However, Brazil, hosts for cycle remain unknown. We hypothesized that free-living NHPs might play a role urban/periurban ZIKV dynamics, thus we undertook an NHP investigation two cities Brazil. identified ZIKV-positive and sequences obtained were phylogenetically related to American lineage Additionally, inoculated four C . penicillata with our results demonstrated marmosets had sustained...
The emergence of the Brazilian variant concern, Gamma lineage (P.1), impacted epidemiological profile COVID-19 cases due to its higher transmissibility rate and immune evasion ability.
Arthropod-borne viruses (arboviruses) are transmitted by arthropod vectors to humans, leading disease outbreaks mainly in tropical regions of the world.1Weaver SC Charlier C Vasilakis N Lecuit M Zika, chikungunya, and other emerging vector-borne viral diseases.Annu Rev Med. 2018; 69: 395-408Crossref PubMed Scopus (234) Google Scholar Although many arboviruses known, three Aedes-spp-borne particularly concerning for humans at a global scale due recurring large expanding epidemic dengue virus,...
Abstract We describe a vaccinialike virus, Araçatuba associated with cowpoxlike outbreak in dairy herd and related case of human infection. Diagnosis was based on virus growth characteristics, electron microscopy, molecular biology techniques. Molecular characterization the done by using polymerase chain reaction amplification, cloning, DNA sequencing conserved orthopoxvirus genes such as vaccinia factor (VGF), thymidine kinase (TK), hemagglutinin. used VGF-homologous TK gene nucleotide...
Abstract Background Nosocomial infections caused by Pseudomonas aeruginosa presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading substantial increase in mortality rates hospitals worldwide. In this context, P. harboring acquired mechanisms resistance, such as production metallo-beta-lactamase (MBLs) and extended-spectrum beta-lactamases (ESBLs) have highest clinical impact. Hence, study was designed investigate presence genes...
Mayaro virus is a neglected tropical arbovirus that causes mild, self-limited febrile syndrome, sometimes accompanied by highly incapacitating arthralgia. First isolated in Trinidad and Tobago 1954, it was reported several countries within the regions of South Central America. Human infections are accidental spillover enzootic cycle. Little epidemiological data available due to inadequate surveillance generic nature clinical manifestations resulting misdiagnosis with other viral fevers....