A5077065332- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Malaria Research and Control
- Mosquito-borne diseases and control
- Venomous Animal Envenomation and Studies
- SARS-CoV-2 and COVID-19 Research
- Rabies epidemiology and control
- Cardiac Structural Anomalies and Repair
- Hemoglobinopathies and Related Disorders
- Cardiac Valve Diseases and Treatments
- Respiratory Support and Mechanisms
- Infective Endocarditis Diagnosis and Management
- Neonatal Health and Biochemistry
- Thermal Regulation in Medicine
- Metabolomics and Mass Spectrometry Studies
- Transcranial Magnetic Stimulation Studies
- HIV-related health complications and treatments
- Drug-Induced Ocular Toxicity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Muscle activation and electromyography studies
- Bone health and osteoporosis research
- Pericarditis and Cardiac Tamponade
- Fungal Infections and Studies
- COVID-19 diagnosis using AI
- Bone health and treatments
Fundação de Medicina Tropical
2014-2025
Universidade do Estado do Amazonas
2017-2025
Escola Superior de Ciências da Saúde
2017-2024
Universidade Federal do Amazonas
2020-2024
Universidade de Brasília
2024
Universidade Federal do Espírito Santo
2023
Fundação Oswaldo Cruz
2017-2021
Fundação Getulio Vargas
2020
Universidade Federal do Acre
2020
Universidade de São Paulo
2013
<h3>Importance</h3> There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the effect of chloroquine diphosphate (CQ) requires a high concentration drug. <h3>Objective</h3> To evaluate safety and efficacy 2 CQ dosages in patients with severe COVID-19. <h3>Design, Setting, Participants</h3> This parallel, double-masked, randomized, phase IIb clinical trial 81 adult who were hospitalized acute respiratory syndrome (SARS-CoV-2)...
Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating inflammatory response, mainly lungs, triggered by severe acute respiratory syndrome 2 (SARS-CoV-2). This study aimed to evaluate efficacy methylprednisolone (MP) among hospitalized patients with suspected COVID-19.A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed aged ≥18 years clinical, epidemiological, and/or radiological COVID-19 at...
Treatment of Plasmodium vivax malaria requires the clearing asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for radical cure P. vivax.
Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. parasitemia and hypnozoites, termed "radical cure."
Summary Background There is no specific antiviral therapy recommended for the disease caused by SARS-CoV-2 (COVID-19). Recent publications have drawn attention to possible benefit of chloroquine (CQ). Our study aimed comprehensively evaluate safety and efficacy two different CQ dosages in patients with established severe COVID-19. Methods We performed a parallel, double-blinded, randomized, phase IIb clinical trial, aiming assess as adjunctive hospitalized SARS Manaus, Brazilian Amazon....
COVID-19 is still placing a heavy health and financial burden worldwide. Impairment in patient screening risk management plays fundamental role on how governments authorities are directing resources, planning reopening, as well sanitary countermeasures, especially regions where poverty major component the equation. An efficient diagnostic method must be highly accurate, while having cost-effective profile. We combined machine learning-based algorithm with mass spectrometry to create an...
Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings adrenal glands 28 with confirmed SARS-CoV-2 infection. Microscopic lesions were identified 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four cortical lipid degeneration; two hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis patient inflammation association other three observed. No...
Bothrops atrox snakes are mostly endemic of the Amazon rainforest and is certainly South American pit viper responsible for most snakebites in region. The composition B. venom significantly known has been used to trace relevance phenotype snake biology impacts clinics human patients involved accidents by atrox. However, spite wide distribution great medical snakes, taxonomy not fully resolved lack taxonomic resolution on studies focused or envenoming currently unknown. presents different...
The continuous evolution of SARS-CoV-2 is an expected phenomenon that will continue to happen due the high number cases worldwide. present study analyzed how a Variant Concern (VOC) could still circulate in population hardly affected by two COVID-19 waves and with vaccination progress.
The diagnosis of long COVID is troublesome, even when functional limitations are present. Dynapenia the loss muscle strength and power production that not caused by neurologic or muscular diseases, being mostly associated with changes in function and/or intrinsic force-generating properties skeletal muscle, which altogether, may partially explain seen COVID. This study aimed to identify distribution possible associations dynapenia assessments patients A total 113 COVID-19 were evaluated...
Plasmodium vivax is the most widely distributed human malaria parasite and responsible for large amounts of disease burden [1].The presence P. in bone marrow was first noticed late 19th century [2], examinations sternal aspirates were performed as an accessory to peripheral blood malaria, including [3].Since then, little progress has been made studying infections this tissue.One report explored accumulation dyserythropoietic cells anaemic infected patients [4].In addition, two case studies...
We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies COVID-19 confirmed cases were performed. The died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology peripheral blood galactomannan antigen testing IPA. Aspergillus penicillioides infection was by nucleotide sequencing BLAST analysis. Further reports are needed to assess the occurrence frequency IPA SARS-CoV-2 infections, how they interact...
Various novel platform technologies have been used for the development of COVID-19 vaccines. In this nested cohort study among healthcare workers in Australia and Brazil who received three different COVID-19-specific vaccines, we (a) evaluated incidence adverse events following immunization (AEFI); (b) compared AEFI by vaccine type, dose country; (c) identified factors influencing AEFI; (d) assessed association between reactogenicity anti-spike IgG antibody responses. Of 1302 participants...
Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This an important cause hospitalization among Plasmodium vivax-infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, frequency primaquine-induced hemolysis was 85.2 cases per 100 000 users.
In the Brazilian Amazon, long distances, low healthcare coverage, common use of ineffective or deleterious self-care practices, and resistance to seeking medical assistance have an impact on access antivenom treatment. This study aimed estimate snakebite underreporting, analyze barriers that prevent victims from obtaining in communities located 15 municipalities banks Solimões, Juruá Purus Rivers, remote Western Amazon. Information participants' demographics, previous snakebites, healthcare,...
Snakebites caused by Bothrops snakes are the most prevalent in Amazon region, causing local and systemic complications. Local complications mostly represented necrosis, secondary bacterial infection compartment syndrome. There reports of long-term disabilities, but their burden is poorly investigated. This study aims to describe estimate frequency physical sensory disabilities from snakebites Manaus Region, western Brazilian region. Participants were >18-years individuals that accepted...
Long COVID represents a significant challenge in understanding the prolonged impact of disease. Despite its increasing recognition, detailed insights into long-term cardiopulmonary consequences remain sparse. This study aimed to evaluate functional capacity individuals with persistent symptoms after severe COVID-19 infection compared control without symptomatic or mild 17 months. is case-control assessing 34 divided two groups regarding by distance 6-min walk test (D6MWT) associated gas...