Michele Silva de Jesus
A5012717712- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Leptospirosis research and findings
- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Bacillus and Francisella bacterial research
- Animal Virus Infections Studies
- Education during COVID-19 pandemic
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Innovation and Socioeconomic Development
- Heavy Metal Exposure and Toxicity
- Bacteriophages and microbial interactions
- Science and Education Research
- Water Treatment and Disinfection
- Hepatitis Viruses Studies and Epidemiology
- Mercury impact and mitigation studies
- Enzyme Production and Characterization
- Agricultural and Food Sciences
- Viral Infections and Vectors
- Aquaculture Nutrition and Growth
- COVID-19 epidemiological studies
- Respiratory viral infections research
Fundação Oswaldo Cruz
2008-2024
Leoni (Germany)
2020
Universidade Federal do Amazonas
2008
Abstract The SARS-CoV-2 lineage B.1.1.28 has been evolving in Brazil since February 2020 giving origin to multiple local clades including the new Variant of Concern (VOC) designated P.1 or 501Y.V3. recent emergence sub-lineages with convergent mutations spike (S) protein raises concern about potential impact on viral infectivity and immune escape. We describe here first three confirmed reinfections cases VOC residents Amazonas state, Brazil. Three female patients, 29, 40, 50-year-old, were...
Abstract The Northern Brazilian state of Amazonas is one the most heavily affected country regions by COVID-19 epidemic and experienced two exponential growing waves in early late 2020. Through a genomic epidemiology study based on 250 SARS-CoV-2 genomes from different municipalities sampled between March 2020 January 2021 we revealed that first growth phase was driven mostly dissemination lineage B.1.195 which gradually replaced B.1.1.28. second wave coincides with emergence variant concern...
The continuous evolution of SARS-CoV-2 is an expected phenomenon that will continue to happen due the high number cases worldwide. present study analyzed how a Variant Concern (VOC) could still circulate in population hardly affected by two COVID-19 waves and with vaccination progress.
A new coronavirus [severe acute respiratory syndrome 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of SARS-CoV-2 detected in Manaus, Amazonas, Brazil, protocol designed to generate high-quality full data. The isolate was obtained from an asymptomatic carrier returning Madrid, Spain. Nucleotide sequence analysis showed total nine mutations comparison with original human case Wuhan, China,...
The COVID-19 epidemic in Brazil experienced two major lineage replacements until mid-2021. first was driven by P.2, late 2020, and the second Gamma, early 2021. To understand how these SARS-CoV-2 lineages spread Brazil, we analyzed 11,724 genomes collected throughout country between September 2020 April Our findings indicate that P.2 probably emerged July Rio de Janeiro state Gamma November Amazonas state. Both states were main hubs of viral disseminations to other Brazilian locations. We...
The SARS-CoV-2 variant of concern (VOC) Delta was first detected in India October 2020. imported cases the Brazil were identified April 2021 southern region, followed by more different regions during following months. By early September 2021, already dominant southeastern (87%), (73%), and northeastern (52%) Brazilian regions. This study aimed to understand spatiotemporal dissemination dynamics Brazil. To this end, we employed a combination maximum likelihood (ML) Bayesian methods...
INTRODUCTION: Leptospirosis is an infectious disease caused by microorganisms of the genus Leptospira that affects several species animals, including human beings. The study described confirmed cases leptospirosis in Manaus, from 2000 to 2010. METHODS: A descriptive based on secondary data analysis Secretaria Municipal de Saúde (SEMSA), Sistema Informação Agravos Notificação SINAN and sobre Mortalidade (SIM) analyzing variables: age group, gender, clinical aspects geographic area lethality....
The disease coronavirus COVID-19 has been the cause of millions deaths worldwide. Among proteins SARS-CoV-2, non-structural protein 12 (NSP12) plays a key role during COVID infection and is part RNA-dependent RNA polymerase complex. monitoring NSP12 polymorphisms extremely important for design new antiviral drugs viral evolution. This study analyzed mutations detected in circulating SARS-CoV-2 years 2020 to 2022 population city Manaus, Amazonas, Brazil. most frequent found were P323L G671S....
The most common bacterial mercury resistance mechanism is based on the reduction of Hg(II) to Hg(0), which dependent mercuric reductase enzyme (MerA) activity. use a 431 bp fragment conservative region (merA) gene was applied as molecular marker this mechanism, allowing identification resistant strains.
Summary The Amazonas was one of the most heavily affected Brazilian states by COVID-19 epidemic. Despite a large number infected people, particularly during second wave associated with spread Variant Concern (VOC) Gamma (lineage P.1), SARS-CoV-2 continues to circulate in Amazonas. To understand how persisted human population high immunity barrier, we generated 1,188 whole-genome sequences from individuals diagnosed state 1st January 6th July 2021, which 38 were vaccine breakthrough...
Leptospirosis is caused by a bacterium of the genus Leptospira. This study aimed at investigating seroprevalence and risk factors for leptospirosis in humans Manaus, State Amazonas.Interviews were performed, 1,000 blood serum samples examined using microscopic agglutination test.Forty-three cases positive; there 10 serotypes, with coagglutination 8 cases. The most frequently occurring serotypes Icterohaemorrhagiae (20.7%), Cynopteri Australis (18.8%), Copenhageni (16.9%), Midwest (54.7%)...
Summary The rapid spread of the SARS-CoV-2 Variant Concern (VOC) Gamma during late 2020 and early 2021 in Brazilian settings with high seroprevalence raised some concern about potential role reinfections driving epidemic. Very few cases reinfection associated VOC Gamma, however, have been reported. Here we describe 25 confirmed by real-time RT-PCR twice within months apart Brazil. genomic analysis that individuals were primo-infected between March December distinct viral lineages, including...
The rapid spread of the SARS-CoV-2 Variant Concern (VOC) Gamma in Amazonas during early 2021 fueled a second large COVID-19 epidemic wave and raised concern about potential role reinfections. Very few cases reinfection associated with VOC have been reported to date, their impact on clinical, immunological, virological parameters remains largely unexplored. Here we describe 25 Brazil. genomic analysis confirmed that individuals were primo-infected distinct viral lineages between March...
The coronavirus disease COVID-19 has been the cause of millions deaths worldwide. Among SARS-CoV-2 proteins, non-structural protein 1 (NSP1) great importance during virus infection process and is present in both alpha beta-CoVs. Therefore, monitoring NSP1 polymorphisms crucial order to understand their role virus-induced pathogenicity. Herein, we analyzed how mutations detected circulating population city Manaus, Amazonas state, Brazil could modify tertiary structure protein. Three were...