Victor Costa de Souza
A5020319995- Mosquito-borne diseases and control
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Virology and Viral Diseases
- Plant Virus Research Studies
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Bacillus and Francisella bacterial research
- Dengue and Mosquito Control Research
- Herpesvirus Infections and Treatments
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Bacterial Infections and Vaccines
- Parvovirus B19 Infection Studies
- Insect symbiosis and bacterial influences
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Viral gastroenteritis research and epidemiology
- Rabies epidemiology and control
- Syphilis Diagnosis and Treatment
Fundação Oswaldo Cruz
2015-2024
Amazon (United States)
2019-2021
Universidade do Extremo Sul Catarinense
2021
Universidade Federal do Rio de Janeiro
2021
Pfizer (United States)
2012-2020
Universidade Federal do ABC
2013
Leoni (Germany)
2013
Instituto Federal do Amazonas
2007
Pearl River Community College
2004-2007
Universidade Federal de Minas Gerais
2007
We characterized 3 autochthonous dengue virus serotype cases and 1 imported case from 2 states in the North South Regions of Brazil, 15 years after Brazil's last outbreak involving this serotype. also identified a new Asian lineage recently introduced into Americas, raising concerns about future outbreaks.
This study aimed to investigate the circulation of Orthobunyavirus species in state Mato Grosso (MT) Brazil. During a dengue outbreak 2011/2012, 529 serum samples were collected from patients with acute febrile illness symptoms for up five days and 387 pools female Culex quinquefasciatus captured 2013 subjected nested-reverse transcription-polymerase chain reaction segment S Simbu serogroup followed by nucleotide sequencing virus isolation Vero cells. Patients (5/529; 0.9%) Cuiabá (n = 3),...
To improve the clinical diagnosis of pneumococcal infection in bacteremic and nonbacteremic community-acquired pneumonia (CAP), a Luminex technology-based multiplex urinary antigen detection (UAD) diagnostic assay was developed validated. The UAD can simultaneously detect 13 different serotypes Streptococcus pneumoniae by capturing serotype-specific S. polysaccharides (PnPSs) secreted human urine. Assay specificity is achieved with monoclonal antibodies (MAbs) on spectrally unique...
We describe a sensitive method for simultaneous detection of Oropouche and Oropouche-like viruses carrying the S segment, as well Mayaro virus, using multiplexed one-step reverse transcription real-time polymerase chain reaction (RT-qPCR). A chimeric plasmid containing both targets was designed evaluated in vitro production transcribed RNA, which could be easily used non-infectious external control. To track false-negative results due to PCR inhibition or equipment malfunction, MS2...
Background Since its first detection in the Caribbean late 2013, chikungunya virus (CHIKV) has affected 51 countries Americas. The CHIKV epidemic Americas was caused by CHIKV-Asian genotype. In August 2014, local transmission of genotype detected Brazilian Amazon region. However, a distinct lineage, CHIKV-East-Central-South-America (ECSA)-genotype, nearly simultaneously Feira de Santana, Bahia state, northeast Brazil. genomic diversity and dynamics region remains poorly understood despite...
Abstract The SARS-CoV-2 lineage B.1.1.28 has been evolving in Brazil since February 2020 giving origin to multiple local clades including the new Variant of Concern (VOC) designated P.1 or 501Y.V3. recent emergence sub-lineages with convergent mutations spike (S) protein raises concern about potential impact on viral infectivity and immune escape. We describe here first three confirmed reinfections cases VOC residents Amazonas state, Brazil. Three female patients, 29, 40, 50-year-old, were...
The continuous evolution of SARS-CoV-2 is an expected phenomenon that will continue to happen due the high number cases worldwide. present study analyzed how a Variant Concern (VOC) could still circulate in population hardly affected by two COVID-19 waves and with vaccination progress.
ABSTRACT The Brazilian western Amazon region is currently experiencing its largest laboratory confirmed Oropouche virus (OROV) outbreak, with nearly 6,000 reported cases in the states of Amazonas (AM), Acre (AC), Rondônia (RO), and Roraima (RR), between August 2022 March 2024. Here, we sequenced analyzed 382 full-length OROV genomes from human samples collected 2024 all four states, aiming to trace origin genetic evolution leading current outbreak. Genomic analyses revealed that recent...
Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub Amazon region, little known about there, terms both transmission viral genetic diversity. Using portable genome sequencing, we generated 59 genomes Manaus. Phylogenetic analyses indicated multiple introductions from...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected almost 200 million people worldwide by July 2021 and the pandemic been characterized infection waves of viral lineages showing distinct fitness profiles. The simultaneous a single individual two SARS-CoV-2 may impact COVID-19 disease progression provides window opportunity for recombination emergence new with differential phenotype. Several hundred are currently well phylogenetically defined, but main factors have...
Background Arboviruses are viruses transmitted to humans and other animals by the bite of hematophagous arthropods. Infections caused chikungunya virus (CHIKV), dengue (DENV), Zika (ZIKV), deadlier yellow fever (YFV) current public health problems in several countries, mainly those located tropical subtropical regions. One main prevention strategies continues be vector control, with elimination breeding sites surveillance infested areas. The use ovitraps for Aedes mosquitos monitoring has...
Mutations at both the receptor-binding domain (RBD) and amino (N)-terminal (NTD) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations concern RBD independently acquired convergent deletions insertions NTD S protein, which altered antigenic-supersite other predicted epitopes this region. Importantly, we detected community transmission...
One of the most remarkable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants concern (VOC) features is significant number mutations they acquired. However, specific factors that drove emergence such since second half 2020 are not fully resolved. In this study, we describe a new SARS-CoV-2 P.1 sub-lineage circulating in Brazil, denoted here as Gamma-like-II, well previously described lineage Gamma-like-I shares several lineage-defining with VOC Gamma. Reconstructions...
The COVID-19 epidemic in Brazil experienced two major lineage replacements until mid-2021. first was driven by P.2, late 2020, and the second Gamma, early 2021. To understand how these SARS-CoV-2 lineages spread Brazil, we analyzed 11,724 genomes collected throughout country between September 2020 April Our findings indicate that P.2 probably emerged July Rio de Janeiro state Gamma November Amazonas state. Both states were main hubs of viral disseminations to other Brazilian locations. We...
Abstract The SARS-CoV-2 variants of concern (VOCs) Delta and Omicron spread globally during mid late 2021, respectively. In this study, we compare the dissemination dynamics these VOCs in Amazonas state, one Brazil’s most heavily affected regions. We sequenced virus genome from 4128 patients collected between July 1st, January 31st, 2022, investigated viral using a phylodynamic approach. BA.1 displayed similar patterns phylogeographic but different epidemic dynamics. replacement Gamma by was...
Sulfonated carbon-based catalysts were prepared from agroindustrial wastes (sugar cane bagasse, coconut husk, and coffee grounds). These showed high activity for glycerol etherification with tert-butyl alcohol. Yields of mono-tert-butyl (MTBG), di-tert-butyl (DTBG), tri-tert-butyl-glycerol (TTBG) higher than that obtained using Amberlyst-15 commercial resin. At 393 K 5 wt % catalyst loading, conversion selectivity to DTBG+TTBG after 4 h reaction time 80.9% 21.3%, respectively, the sugar...
Abstract Background Identifying Streptococcus pneumoniae serotypes by urinary antigen detection (UAD) assay is the most sensitive way to evaluate epidemiology of nonbacteremic community-acquired pneumonia (CAP). We first described a UAD detect S. 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, covered licensed 13-valent conjugate vaccine. To assess substantial remaining pneumococcal disease burden after introduction several vaccines, UAD-2 was developed 11 additional (2, 8, 9N, 10A,...
The SARS-CoV-2 variant of concern (VOC) Delta was first detected in India October 2020. imported cases the Brazil were identified April 2021 southern region, followed by more different regions during following months. By early September 2021, already dominant southeastern (87%), (73%), and northeastern (52%) Brazilian regions. This study aimed to understand spatiotemporal dissemination dynamics Brazil. To this end, we employed a combination maximum likelihood (ML) Bayesian methods...
Abstract Dengue virus serotype 2, genotype Cosmopolitan (DENV-2-GII), is one of the most widespread DENV strains globally. In USA, DENV-2 epidemics have been dominated by Asian-American (DENV-2-GIII), and first cases DENV-2-GII were only described in 2019, Peru, 2021 Brazil. To gain new information about circulation Brazil, we sequenced 237 confirmed sampled between March 2023 revealed that already present all geographic regions The phylogeographic analysis inferred was introduced at least...