A5017366244- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Evolution and Genetic Dynamics
- Animal Virus Infections Studies
- Escherichia coli research studies
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Ecosystem dynamics and resilience
- CRISPR and Genetic Engineering
- Bacillus and Francisella bacterial research
- Antibiotic Resistance in Bacteria
- Animal Genetics and Reproduction
- Respiratory viral infections research
- Salmonella and Campylobacter epidemiology
- Chromosomal and Genetic Variations
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Bacteriophages and microbial interactions
Hokkaido University
2021-2023
Kasetsart University
2021
The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become widespread across world in a flashing manner. As December 7, 2021, total 758 cases were confirmed Denmark. Using nucleotide sequences Delta and variants registered from Denmark GISAID database, we found that effective (instantaneous) reproduction number is 3.19 (95% confidence interval [CI]: 2.82-3.61) times greater than under same epidemiological conditions. proportion infections among all...
Using numbers of SARS-CoV-2 variants detected in Japan as at 13 June 2021, relative instantaneous reproduction (R RI ) the R.1, Alpha, and Delta with respect to other strains circulating were estimated 1.25, 1.44, 1.95. Depending on assumed serial interval distributions, R varies from 1.20–1.32 for 1.34–1.58 1.70–2.30 Delta. The frequency is expected take over Alpha before 23 July 2021.
<abstract> <p>The Omicron variant spreads fastest as ever among the severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) we had so far. The BA.1 and BA.2 sublineages of are circulating worldwide it is urgent to evaluate transmission advantages these sublineages. Using a mathematical model describing trajectories frequencies that assumes constant ratio in mean generation times effective reproduction numbers variants, Denmark from November 22, 2021 February 26, 2022 were...
Abstract The SARS-CoV-2 variants of concern (VOCs) Delta and Omicron spread globally during mid late 2021, respectively. In this study, we compare the dissemination dynamics these VOCs in Amazonas state, one Brazil’s most heavily affected regions. We sequenced virus genome from 4128 patients collected between July 1st, January 31st, 2022, investigated viral using a phylodynamic approach. BA.1 displayed similar patterns phylogeographic but different epidemic dynamics. replacement Gamma by was...
Abstract The Omicron variant is the most transmissible of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) we had so far. BA.1 and BA.2 sublineages are circulating in Europe it urgent to evaluate transmissibility these sub-lineages. Using a mathematical model describing trajectories frequencies that assumes constant ratio generation times effective reproduction numbers among variants, Denmark from November 22, 2021 February 26, 2022 were analyzed. We found 0.60 (95%CI: 0.59–0.62)...
Abstract The B.1.1.7 strain, also referred to as Alpha variant, is a variant strain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). considered possess higher transmissibility compared strains previously circulating in England. This paper proposes new method estimate selective advantage mutant over another using time course frequencies and distribution serial interval infections. allows instantaneous reproduction numbers infections vary calendar time. proposed assumes...
Abstract Using numbers of SARS-CoV-2 variants detected in Japan, the relative instantaneous reproduction R.1, Alpha, and Delta with respect to other strains circulating Japan were estimated at 1.245, 1.437, 1.948, respectively. The can vary within 1.190–1.319 for 1.335–1.580 1.703–2.30 depending on assumed serial interval distributions. frequency is expected take over Alpha around July 12, 2021.
Although many drug-resistant nontyphoidal Salmonella (NTS) infections are reported globally, their treatment is challenging owing to the ineffectiveness of currently available antimicrobial drugs against resistant bacteria. It therefore essential discover novel for management these infections. In this study, we report high inhibitory activities fluoroquinolones (FQs; WQ-3810 and WQ-3334) with substitutions at positions R-1 by 6-amino-3,5-difluoropyridine-2-yl R-8 methyl group or bromine,...
New variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high effective reproduction numbers are continuously being selected by natural selection. To establish control measures for new variants, it is crucial to know their transmissibility and replacement trajectory in advance. In this paper, we conduct retrospective prediction tests variant from Alpha Delta England, using relative respect estimated partial observations. We found that once Delta's frequency...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continuously evolved since its introduction to the human population in 2019. Natural selection selects variants with higher effective reproduction numbers, increasing overall transmissibility of circulating viruses. In order establish control measures for a new variant, it is crucial know and replacement time course early phases variant replacement. this paper, we conduct retrospective prediction tests from Alpha...
Abstract In 2009, a new strain of H1N1 influenza A virus caused pandemic, and its descendant strains are causing seasonal epidemics worldwide. Given the high mutation rate viruses, variant having different amino acids on hemagglutinin (HA) continuously emerge. To prepare vaccine for next seasons, it is an urgent task to predict which variants will be selected in viral population. An analysis 24,681 pairs acid sequence HA H1N1pdm2009 viruses patient age showed that empirical fixation...
ABSTRACT The SARS-CoV-2 variants of concern (VOCs) Delta and Omicron spread globally during mid late 2021, respectively, with variable impact according to the immune population landscape. In this study, we compare dissemination dynamics these VOCs in Amazonas state, one Brazil’s most heavily affected regions. We sequenced virus genome from 4,128 patients collected between July 1st, 2021 January 31st, 2022 investigated lineage replacement using a phylodynamic approach. displayed similar...