A5042780289- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect and Pesticide Research
- Viral Infections and Vectors
- Toxin Mechanisms and Immunotoxins
- Parasite Biology and Host Interactions
- Synthesis and Biological Evaluation
- Insect symbiosis and bacterial influences
- Insect Pest Control Strategies
- Parasites and Host Interactions
- Synthesis and biological activity
- Insect Resistance and Genetics
- Traditional and Medicinal Uses of Annonaceae
- Venomous Animal Envenomation and Studies
- Helminth infection and control
- Parasitic Diseases Research and Treatment
- Vector-borne infectious diseases
- Phytochemical compounds biological activities
- Synthesis and Characterization of Heterocyclic Compounds
- Medical and Pharmaceutic Studies
- Dermatological diseases and infestations
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 epidemiological studies
Universidad de Antioquia
2015-2024
Universidade de São Paulo
2023
United States Army Medical Research Institute of Infectious Diseases
2021-2022
Universitat de València
1998-2020
ORCID
2020
World Health Organization
2009-2012
Instituto de Salud Carlos III
2012
Centro Nacional de Microbiologia
2012
University of California, San Francisco
2012
World Health Organization Regional Office for South-East Asia
2012
As part of a World Health Organization-led effort to update the empirical evidence base for leishmaniases, national experts provided leishmaniasis case data last 5 years and information regarding treatment control in their respective countries comprehensive literature review was conducted covering publications on 98 three territories (see 'Leishmaniasis Country Profiles Text S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11, S12, S13, S14, S15, S16, S17, S18, S19, S20, S21, S22, S23, S24, S25,...
Multilocus genotyping of microbial pathogens has revealed a range population structures, with some bacteria showing extensive recombination and others almost complete clonality. The structure the protozoan parasite Plasmodium falciparum been harder to evaluate, since most studies have used limited number antigen-encoding loci that are known be under strong selection. We describe length variation at 12 microsatellite in 465 infections collected from 9 locations worldwide. These data reveal...
Abstract Zika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this and mosquito control strategies have not been adequate to contain virus. A promising candidate arbovirus prevention relies on introduction intracellular bacterium Wolbachia into Aedes aegypti mosquitoes. This primarily has proposed as a tool dengue (DENV) transmission; however, evidence suggests infections confer protection...
Background New approaches to preventing chikungunya virus (CHIKV) are needed because current methods limited controlling mosquito populations, and they have not prevented the invasion of this into new locales, nor been sufficient control upon arrival. A promising candidate for arbovirus prevention relies on introduction intracellular bacterium Wolbachia Aedes aegypti mosquitoes. This primarily has proposed as a tool dengue (DENV) transmission; however, evidence suggests infections confer...
Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. parasitemia and hypnozoites, termed "radical cure."
Background The introduction of Wolbachia ( w Mel strain) into Aedes aegypti mosquitoes reduces their capacity to transmit dengue and other arboviruses. Randomised non-randomised studies in multiple countries have shown significant reductions incidence following field releases Mel-infected Ae . We report the public health outcomes from phased, large-scale Mel- throughout three contiguous cities Aburrá Valley, Colombia. Methodology/Principal findings Following pilot 2015–2016, staged city-wide...
We present evidence that the El Niño phenomenon intensifies annual cycle of malaria cases for Plasmodium vivax and falciparum in endemic areas Colombia as a consequence concomitant anomalies normal temperature precipitation. used simultaneous analyses both variables at timescales, well correlation power spectral detailed spatial (municipal) temporal (monthly) records. During "normal years," rural exhibits clear-cut "normal" cycle, which is tightly associated with prevalent climatic...
ABSTRACT Parasitologic confirmation of cutaneous leishmaniasis is obligatory before chemotherapy can be considered. Direct microscopic examination scrapings taken from indurated borders ulcers has been routinely used as primary method diagnosis. In this report we compared the sensitivity dermal bottoms (BDS) with that active margins lesions (MDS) in a total 115 patients. The sensitivities were 90.4 and 78.3% for BDS MDS samples, respectively. When PCR was group 40 patients, also observed...
Miltefosine is an oral agent used for cutaneous leishmaniasis treatment. An open-label, randomized, phase III clinical trial was carried out in the Colombian army population. Miltefosine, 50 mg capsule taken orally three times per day 28 days (N = 145) or meglumine antimoniate, 20 mg/kg body weight by intramuscular injection 143). The efficacy of miltefosine protocol 69.8% (85/122 patients) and 58.6% (85/145 intention to treat. For 85.1% (103/121 72% (103/143 No association found between...
We conducted a case-control study to evaluate risk factors for visceral leishmaniasis during an epidemic in previously unaffected district of Ethiopia. also collected blood and bone marrow specimens from dogs the outbreak villages. In multivariable analyses 171 matched pairs, dog ownership, sleeping under acacia tree day, habitually outside at night were associated with significantly increased risk. Specimens 7 (3.8%) positive by immunofluorescent antibody test (IFAT) both enzyme-linked...
Background. A safe, effective tetravalent dengue vaccine is a global health priority. The safety and immunogenicity of live attenuated, recombinant candidate (TDV) were evaluated in healthy volunteers from dengue-endemic countries.
Sand flies include a group of insects that are medical importance and vary in geographic distribution, ecology, pathogen transmission. Approximately 163 species sand have been reported Colombia. Surveillance the presence fly actualization distribution important for predicting risks monitoring expansion diseases which can transmit. Currently, identification phlebotomine is based on morphological characters. However, requires considerable skills taxonomic expertise. In addition, significant...
The rise in dengue fever cases and the absence of vaccines will likely cause governments to consider various types effective means for controlling disease. Given strong public interests potential vaccines, it is essential understand private economic benefits accelerated introduction into sector program markets high-risk countries.A contingent valuation study a hypothetical vaccine was administered 400 households multi-country setting: Vietnam, Thailand, Colombia. All respondents received...
<p><strong>Introducción.</strong> <em>Aedes aegypti</em> es el principal vector de fiebre amarilla urbana, dengue, chikungunya y zika. Se ha demostrado que la distribución biogeográfica esta especie se expandido debido al calentamiento global a factores socioeconómicos culturales. Los cambios en los patrones altitudinal este su infección con virus son prioridades investigación encaminada desarrollar estrategias vigilancia entomológica virológica salud...