A5107559234- Genetic Associations and Epidemiology
- Forensic and Genetic Research
- Genetic and phenotypic traits in livestock
- Nutrition, Genetics, and Disease
- Race, Genetics, and Society
- Genetic diversity and population structure
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Health and Lifestyle Studies
- Metabolism, Diabetes, and Cancer
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Agricultural and Food Production Studies
- Comparative constitutional jurisprudence studies
- Diet, Metabolism, and Disease
- Indigenous Studies and Ecology
- Legal processes and jurisprudence
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Metabolism and Genetic Disorders
- Alcohol Consumption and Health Effects
- Genomic variations and chromosomal abnormalities
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Research on Leishmaniasis Studies
- Migraine and Headache Studies
Antioquia Institute of Technology
2017-2021
Universidad de Antioquia
2008-2019
University College London
2012
Universidad de Los Andes
2011
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped 422 individuals representing 24 Native populations sampled from North, Central, South America. These data were analyzed jointly with similar available 54 other indigenous worldwide, including an additional five groups. The have lower greater differentiation than continental regions. observe gradients both of decreasing as a function geographic distance Bering...
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis complex traits through admixture mapping. However, no genome-wide characterization across has yet been attempted. Here, we report an analysis in thirteen Mestizo populations (i.e. regions mainly European Native settlement) from seven countries based on data 678 autosomal 29 X-chromosome microsatellites. We found extensive variation American ancestry (and generally low levels...
Colombia is a country with great geographic heterogeneity and marked regional differences in pre-Columbian native population density the extent of past African European immigration. As result, has one most diverse populations Latin America. Here we evaluated ancestry over 1,700 individuals from 24 Colombian using biparental (autosomal X-Chromosome), maternal (mtDNA), paternal (Y-chromosome) markers. Autosomal varies markedly both within between regions, confirming genetic diversity...
Summary We report an integrated analysis of nuclear (autosomal, X‐ and Y‐chromosome) short tandem repeat (STR) data mtDNA D‐loop sequences obtained in the same set 22 Native populations from across Americas. A north to south gradient decreasing population diversity was observed, agreement with a settlement Americas extreme northwest continent. This correlation is stronger “least cost distances,” which consider coasts as facilitators migration. Continent‐wide estimates structure are highest...
The "thrifty genotype" hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin has a genetic basis reflects an evolutionary adaptation to past low calorie/high exercise lifestyle. However, identification gene variants underpinning this remains elusive. Here we assessed role American ancestry, socioeconomic status (SES) 21 candidate loci susceptibility T2D sample 876 cases 399 controls from Antioquia (Colombia). Although mean ancestry is...
We performed a whole genome microsatellite marker scan in six multiplex families with bipolar (BP) mood disorder ascertained Antioquia, historically isolated population from North West Colombia. These were characterized clinically using the approach employed independent ongoing studies of BP closely related Central Valley Costa Rica. The most consistent linkage results parametric and non-parametric analyses Colombian involved markers on 5q31–33, region implicated by previous Because these...
Introduction : Obesity results from interaction between genetic and environmental risk factors.To evaluate the effect of three gene variants factors on obesity overweight in young people aged 10 to 18 years a Colombian population.A total 424 subjects were selected separated into groups for cross-sectional study; 100 obese 112 matched with 212 normal-weight controls. Associations evaluated excess weight polymorphisms ( UCP3- rs1800849, FTO -rs17817449, CAPN10 -rs3842570), as well family...
<i>Background/Aims:</i> Bipolar disorder (BP) is a severe psychiatric illness, characterised by alternating episodes of depression and mania, which ranks among the top ten causes morbidity life-long disability world-wide. We have previously performed whole-genome linkage scan on 6 pedigrees segregating BP from well-characterised population isolate Antioquia, Colombia. recently collected genotypes for same set 382 autosomal microsatellite markers in 9 additional Antioquian...
Introduction. The uncoupling proteins belong to the family of anion transporting which uncouple ATP production from mitochondrial respiration, cause proton leakage through inner membrane, and release energy as heat. Although protein function has not been well established, specific polymorphisms in these have associated with type 2 diabetes mellitus, obesity insulin resistance.Objective. association was assessed between genes 1, 3 mellitus.Materials methods. In a northwestern Colombian...
Hypertension is a multifactorial disease influenced by genetic and environmental components, with its prevalence varying across ethnic groups. Manifold studies on blood pressure regulatory system genes have been carried out -such as the renin-angiotensin-aldosterone system, sympathetic nervous endothelial factor, sodium balance-, but results yielded were inconsistent among populations.To evaluate effect of both variants in AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R PTGS2,...
A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association 10 metabolic syndrome candidate genes with excess weight and adiposity evaluate effect perinatal socioeconomic factors these associations. anthropometry, conditions polymorphisms were evaluated 1081 young people between 18 years old. Genotypic associations calculated using logistic linear models adjusted by age, gender, pubertal maturation, genetic risk score (GRS) was...
Host genetics is recognized as an influential factor for the development of dengue disease.This study evaluated association with polymorphisms rs8192284 gene IL6R, rs3775290 TLR3, and rs7248637 DC-SIGN.Of 292 surveyed subjects, 191 were confirmed fever remaining 101 included controls. The genotypes resolved using polymerase chain reaction restriction fragment length polymorphism (PCRRFLP). In attempt to determine risk (Odds Ratio) suffering fever, data analyzed chi-square alleles logistic...
Introducción: El exceso de peso en niños y adolescentes es una pandemia que aumenta el riesgo mortalidad por enfermedades crónicas no transmisibles.Se ha estimado aun etapas tempranas la vida, se asocia con alteraciones metabólicas; sin embargo, necesario establecer si nuestro medio estas evidencian población menor 19 años.Objetivo: Comparar perfil lipídico ingesta frutas verduras, según índice masa corporal, un grupo jóvenes 10 a años, empresa promotora salud SURA, sede Medellín.Métodos:...
Abstract We previously reported linkage of bipolar disorder to 5q33‐q34 in families from two closely related population isolates, the Central Valley Costa Rica (CVCR) and Antioquia, Colombia (CO). Here we present follow up results fine‐scale mapping large CVCR CO segregating severe disorder, BP‐I, 343 trios/duos CO. Employing densely spaced SNPs fine map prior peak region increases evidence clarifies position putative BP‐I locus. performed two‐point analysis with 1134 an approximately 9 Mb...
Metformin used as a first-line drug to treat Type 2 Diabetes Mellitus is transported via organic cation channels soft tissues. Mutations in the SLC22A1 gene, such Gly401Ser, Ser189Leu, and Arg206Cys, may affect drug’s therapeutic effect on these patients. This study aims at proposing potential structural model for interactions with hOCT1 transporter, well impact of mutations both topological electronic structure levels channel’s surface, from chemical point view with, addition exploring...
La población antioqueña posee una estructura genética compleja que refleja su historia de mezclas entre poblaciones europeas, africanas y amerindias. En este estudio se determinó la composición 849 individuos antioqueña, utilizando un panel 75 marcadores informativos ancestralidad 4 programas implementan métodos bayesianos para inferir mezcla ancestral. contribución europea (60%) fue dos veces mayor amerindia (28%), ambas con distribución amplia, poca africana (12%). Se estimó el tiempo...
Introduction: Obesity results from interaction between genetic and environmental risk factors.Objective: To evaluate the effect of three gene variants factors on obesity overweight in young people aged 10 to 18 years a Colombian population.Materials methods: A total 424 subjects were selected separated into groups for cross-sectional study; 100 obese 112 matched with 212 normal-weight controls. Associations evaluated excess weight polymorphisms (UCP3-rs1800849, FTO-rs17817449,...