Víctor Acuña-Alonzo
A5102960772- Genetic and phenotypic traits in livestock
- melanin and skin pigmentation
- T-cell and B-cell Immunology
- Genetic Associations and Epidemiology
- dental development and anomalies
- Skin Protection and Aging
- Morphological variations and asymmetry
- Immune Cell Function and Interaction
- Cleft Lip and Palate Research
- Genetic Mapping and Diversity in Plants and Animals
- Hair Growth and Disorders
- Evolutionary Psychology and Human Behavior
- Forensic Anthropology and Bioarchaeology Studies
- Body Composition Measurement Techniques
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Forensic and Genetic Research
- Cancer-related molecular mechanisms research
- Indigenous Studies and Ecology
- RNA regulation and disease
- Gout, Hyperuricemia, Uric Acid
- Child Nutrition and Water Access
- Genomics and Chromatin Dynamics
- Psychedelics and Drug Studies
- Genetics and Physical Performance
Laboratory of Molecular Genetics
2013-2023
National Institute of Anthropology and History
2012-2023
Biogéosciences
2022
Université Bourgogne Franche-Comté
2022
École Pratique des Hautes Études
2022
Centre National de la Recherche Scientifique
2022
University of North Carolina at Chapel Hill
2022
Escuela Nacional de Antropología e Historia
2012-2020
University College London
2014-2018
National Institute of Genomic Medicine
2012
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic within over 1000 individuals representing 20 indigenous 11 mestizo populations. found striking genetic stratification among populations at varying degrees geographic isolation. Some groups were as differentiated Europeans are East Asians. Pre-Columbian substructure is recapitulated in the ancestry admixed across...
The current genetic makeup of Latin America has been shaped by a history extensive admixture between Africans, Europeans and Native Americans, process taking place within the context geographic social stratification. We estimated individual ancestry proportions in sample 7,342 subjects ascertained five countries (Brazil, Chile, Colombia, México Perú). These individuals were also characterized for range physical appearance traits self-perception ancestry. distribution this reveals population...
Abstract We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. evaluated 14 traits on an ordinal scale and found significant ( P values<5 × 10 −8 ) at single-nucleotide polymorphisms (SNPs) four genomic regions three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) wing (7p13 20p11). In subsample of ∼3,000 individuals we obtained quantitative related to 9 the phenotypes and, also, measure nasion position. Quantitative analyses...
Abstract We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial (beard thickness, monobrow, eyebrow thickness). found 18 signals reaching significance ( P values 5 × 10 −8 to 3 −119 ), including novel associations. These include loci shape balding, the first reported beard thickness. A newly identified locus influencing includes Q30R substitution Protease Serine S1 family member 53 PRSS53 ). demonstrate...
Abstract We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. found eighteen signals at twelve genomic regions. These include one novel locus (in 10q26) three loci eye 1q32, 20q13 22q12). demonstrate the presence multiple independent 11q14 15q13 regions (comprising GRM5/TYR HERC2/OCA2 genes, respectively) several epistatic interactions among independently associated alleles. Strongest with 19p13 was observed an Y182H missense variant...
Common polymorphisms in the fat mass and obesity‐associated gene ( FTO ) have shown strong association with obesity several populations. In present study, we explored of other biochemical parameters Mexican population. We also assessed expression levels adipose tissue obese nonobese individuals. The study comprised 788 unrelated Mexican‐Mestizo individuals 31 subcutaneous biopsies from lean women. single‐nucleotide (SNPs) rs9939609, rs1421085, rs17817449 were associated obesity, particularly...
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental in over 6,500 evaluate impact regional variation on physical appearance. We find American components correspond geographically present-day structure groups, sources non-Native ancestry, admixture timings, match documented migratory flows. also...
Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find significant at seven genomic regions affecting: lobe size and attachment, folding of antihelix, helix rolling, ear protrusion antitragus (linear regression P values 2 × 10(-8) to 3 10(-14)). Four traits are associated with functional variant the Ectodysplasin A receptor (EDAR) gene, key regulator embryonic skin appendage development. confirm expression Edar developing...
We carried out a genome-wide association study in Latin Americans and identified novel face morphology loci..
Summary Tuberculosis remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect susceptibility to tuberculosis, but specific genes involved not yet been fully characterized. NRAMP1/SLC11 A1 and P2X7 linked increased risk for tuberculosis in some African Asiatic populations. To explore potential role these pulmonary a Mexican mestizo population, we evaluated association D543N 3′-UTR polymorphisms − 762 A1513C with...
Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, population genetics studies with particular importance the understanding of human diversity evolution. The aim this study was to describe HLA Mexican admixed individuals. We studied polymorphism MHC class I (HLA-A, -B, -C), II (HLA-DRB1, -DQB1) using high-resolution sequence based typing (SBT) method we structured blocks conserved extended haplotypes (CEHs) 234...
The expression of facial asymmetries has been recurrently related with poverty and/or disadvantaged socioeconomic status. Departing from the developmental instability theory, previous approaches attempted to test statistical relationship between stress experienced by individuals grown in poor conditions and an increase corporal asymmetry. Here we aim further evaluate such hypothesis on a large sample admixed Latin Americans exploring if low status tend exhibit greater fluctuating asymmetry...
We studied HLA class I (HLA-A, -B) and II (HLA-DRB1, -DQB1) allele groups alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states country divided into 78 sample sets, providing information regarding allelic haplotypic frequencies their linkage disequilibrium, as well admixture estimates genetic substructure. identified presence 4268 unique extended haplotypes across Mexico find that ten most frequent (HF > 1%) with significant disequilibrium (Δ'≥0.1)...
Abstract Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated groups. Although classical and recent work shown that studying admixture can yield novel historical insights, the extent which this process contributed adaptation remains underexplored. Here, we introduce a statistical model, specific admixed populations, identifies loci under selection while determining whether likely occurred post-admixture or prior...
A strong association between the proportion of indigenous South American Mapuche ancestry and risk gallbladder cancer (GBC) has been reported in observational studies. Chileans show highest incidence GBC worldwide, are largest people Chile. We set out to assess confounding-free effect individual on investigate mediating effects gallstone disease body mass index (BMI) this association. Genetic markers were selected based informativeness for assignment measure, then used as instrumental...
Abstract We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking 2D portraits and testing for with inter-landmark distances. detected significant associations (P-value <5 × 10 −8 ) at 42 genome regions, nine which have been previously reported. In follow-up analyses, 26 the 33 novel regions replicate East Asians, Europeans, or Africans, one mouse homologous region influences craniofacial morphology mice. The 1q32.3 shows...
The understanding of the complex genotype-phenotype architecture human pigmentation has clear implications for evolutionary history humans, as well medical and forensic practices. Although dozens genes have previously been associated with skin color, knowledge about this trait remains incomplete. In particular, studies focusing on populations outside European-North American axis are rare, and, until now, admixed seldom considered. present study was designed to help fill gap. Our objective...
ABSTRACT Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental genetic factors affecting facial phenotypes. However, the basis determinants both types is far from being completely known. The analysis asymmetries in admixed individuals can be help characterize impact a genome's heterozygosity on developmental fluctuating asymmetries. Here we association between ancestry individual sample Latin‐American populations. To do so,...
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable variability, ancestry proportions, and high burden of growth stunting overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data a sample Hispanic/Latino adults to identify fine-map variants associated with body mass index (BMI), height, BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted GWAS 18 studies/consortia as part...
Abstract Objectives This article aims to assess the contribution of genomic ancestry and socioeconomic status obesity in a sample admixed Latin Americans. Methods The study comprised 6776 adult volunteers from Brazil, Chile, Colombia, Mexico, Peru. Each volunteer completed questionnaire about variables. Anthropometric variables such as weight, height, waist, hip circumference were measured calculate body indices: mass index, waist‐to‐hip ratio waist‐to‐height (WHtR). Genetic data extracted...
Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing AQP4 gene sequencing data to analyze genetic ancestry seek variants conferring NMO susceptibility admixed patients. A total of 164 patients 1,208 controls were included. On average, had proportion than (68.1%...