A5061754603- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- COVID-19 Clinical Research Studies
- Mast cells and histamine
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatologic Treatments and Research
- Influenza Virus Research Studies
- Autoimmune Bullous Skin Diseases
- Pulmonary Hypertension Research and Treatments
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Skin Diseases and Diabetes
- Respiratory viral infections research
- Cardiac Fibrosis and Remodeling
- Hypertrophic osteoarthropathy and related conditions
- Immunodeficiency and Autoimmune Disorders
- COVID-19 and healthcare impacts
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Diagnosis and Treatment of Venous Diseases
- S100 Proteins and Annexins
- Atherosclerosis and Cardiovascular Diseases
- Musculoskeletal pain and rehabilitation
- Sepsis Diagnosis and Treatment
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2015-2024
National Institute of Genomic Medicine
2024
El Colegio de México
2024
ORCID
2023
Instituto Nacional de Enfermedades Respiratorias
2020-2021
McGill University
2021
McGill University Health Centre
2021
Instituto Politécnico Nacional
2020
Washington University in St. Louis
2020
University of California, Irvine
2020
Rationale: A hallmark of pulmonary tuberculosis (TB) is the formation granulomas. However, immune factors that drive a protective granuloma during latent TB, and inflammatory granulomas active are not well defined.Objectives: The objective this study was to identify underlying mechanisms involved in seen TB.Methods: mediators TB were assessed using human samples experimental models Mycobacterium infection, molecular immunologic techniques.Measurements Main Results: We demonstrate patients...
<h3>Objective</h3> To examine the association of skin thickness progression rate (STPR) with mortality, and as a predictor future internal organ involvement in an inception cohort diffuse cutaneous systemic sclerosis (SSc) patients. <h3>Methods</h3> Diffuse SSc patients older than 16 years age evaluated at University Pittsburgh within 2 first evidence thickening between 1980 2005 were eligible. The authors calculated STPR on these patients, examined relationship this variable to development...
Abstract Objective To describe the clinical and laboratory features natural history of disease in systemic sclerosis (SSc; scleroderma) patients with anti–topoisomerase I (anti–topo I) antibody who have different skin thickness progression rates (STPRs). Methods SSc (n = 212) were anti–topo positive divided into 5 subgroups based on STPRs. Skin was measured using modified Rodnan score (MRSS). Anti–topo IgG levels determined. Results Sixty had diffuse cutaneous (dcSSc) rapid progression, 82...
Abstract SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of infection, we have characterized transcriptional signatures induced lungs juvenile and old macaques following infection. Genes associated with Interferon (IFN) signaling, neutrophil degranulation innate immune pathways are significantly lungs, while collagen formation downregulated, as also seen tuberculosis. In COVID-19,...
To characterize a new serum autoantibody in patients with systemic sclerosis (SSc) directed against U11/U12 RNP and to identify the clinical features associated this autoantibody.We identified autoantibodies complex sera of SSc confirmed antibody specificity by immunoprecipitation, reverse transcriptase-polymerase chain reaction, Southern blotting. We determined prevalence these antibodies their for SSc. compared anti-U11/U12 autoantibody-positive negative on demographic, disease...
Objective. Cardiac involvement in SSc is characterized by myocardial fibrosis, arrhythmias and pericarditis. Prevalence studies have shown variable results. The objective of this study was to determine the prevalence cardiac patients using non-invasive, highly sensitive diagnostic methods MRI coronary angiotomography.
Objective.To determine if ischaemia is a causal factor in the development of calcinosis SSc.Methods.Patients with SSc were assessed yearly.Physicians reported presence calcinosis, digital (digital ulcers, necrosis/gangrene, loss pulp on any digits and/or auto-or surgical amputation) and nailfold capillary dropout using dermatoscope.The number was used as an assessment severity ischaemia.SSc specific antibodies detected line immunoassay.Multiple logistic regression Cox proportional hazards...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19), is a global health threat with potential to cause manifestations in lungs. Although COVID-19 has been extensively characterized clinically, factors distinguishing SARS-CoV-2 from other viruses are unknown. Here, we compared clinical, histopathological, and immunological characteristics patients pandemic influenza A(H1N1). We observed higher frequency symptoms, increased tissue...
Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, population genetics studies with particular importance the understanding of human diversity evolution. The aim this study was to describe HLA Mexican admixed individuals. We studied polymorphism MHC class I (HLA-A, -B, -C), II (HLA-DRB1, -DQB1) using high-resolution sequence based typing (SBT) method we structured blocks conserved extended haplotypes (CEHs) 234...
Mesenchymal stem cells (MSC) have received particular attention due to their ability inhibit inflammation caused by cytokine storm induced COVID-19. In this way some patients been treated successfully. The aim of study was evaluate the safety and describe clinical changes after IV administration allogeneic human umbilical cord MSC (ahUCMSC), in with bilateral pneumonia COVID-19, complicated severe ARDS, as compassionate treatment. This a pilot, open-label, prospective, longitudinal study....
There are currently no validated outcome measures to assess calcinosis severity in systemic sclerosis (SSc; scleroderma). We sought develop and validate a novel radiographic scoring system for affecting the hands of SSc patients potential use future clinical trials.Following 1-hour teleconference training session, 12 investigators (8 rheumatologists, 1 dermatologist, 3 radiologists) scored hand radiographs random order using 2 systems (termed “simple” “complex”) re-scored randomly assigned...
SARS-CoV-2 uses the ACE2 receptor and cellular protease TMPRSS2 for entry into target cells. The present study aimed to establish if polymorphisms are associated with COVID-19 disease. included 609 patients confirmed by RT-PCR test 291 individuals negative infection without antibodies anti-SARS-CoV-2. Four (rs12329760, rs2298659, rs456298, rs462574) were determined using 5′exonuclease TaqMan assays. Under different inheritance models, rs2298659 (pcodominant2 = 0.018, precessive 0.006,...
Systemic sclerosis (SSc) shows variable clinical expression among different ethnic groups. Herein, we describe the features, prevalence of organ involvement, and autoantibody profile in Mexican Mestizo SSc patients compare them with from other groups.We included 139 patients. They underwent evaluation were tested for antinuclear antibodies (ANA), anticentromere (ACA), anti-topoisomerase I, anti-RNA polymerase III, anti-U1 RNP, anti-U3 anti-U11/U12 anti-Th/To, anti-PM-Scl, anti-Ku,...
The presence of autoimmune rheumatic diseases in several members the same family, concurrence with non-rheumatic relatives patients, autoantibodies sera from healthy autoimmune-disease development two or more one patient and interplay genetic environmental factors leading to disease and/or their families, is being termed "shared autoimmunity". Herein we analyzed overlap syndromes this context. We performed a retrospective analysis clinical, serological radiological characteristics patients...
Human leukocyte antigen (HLA) polymorphism studies in Systemic Sclerosis (SSc) have yielded variable results. These need to consider the genetic admixture of studied population. Here we used our previously reported definition Mexicans using HLA class I and II DNA blocks map susceptibility develop SSc its complications.We included 159 patients from a cohort Mexican Mestizo patients. We performed clinical evaluation, obtained SSc-associated antibodies, determined alleles sequence-based,...