<h3>Background</h3> Interstitial lung disease (ILD) remains as a mainly cause of morbidity and mortality in patients with systemic sclerosis (SSc). New markers to early detection SSc-ILD are an unmet need [1]. Neutrophil/lymphocyte (NLR) platelet/lymphocyte (PLR) ratios have emerged potential biomarkers inflammation cancer, cardiovascular disorders, infections rheumatic diseases [2]. Recently, some studies South Korea Turkey showed correlation NLR PLR erythrocyte sedimentation rate (ESR),...

Glucocorticoid sensitivity can be measured in vitro using the lymphocyte assay (LSA). In this test, dexamethasone is used to inhibit proliferation of peripheral blood mononuclear cells (PBMC) response mitogens. If PBMC suppressed subjects are considered GC sensitive; if not, they resistant. The LSA has been test some inflammatory diseases but its clinical value systemic lupus erythematosus (SLE) not determined. Herein, we present results from two sisters with SLE who had different disease...

<h3>Background:</h3> Lupus nephopathy (LN) occurs in more than half of patients with systemic lupus erythematosus (SLE). Despite current treatment, 40% progress to kidney failure requiring replacement treatment and transplant, increasing the costs their care precarious quality life [1]. The persistence 24-hour urine protein (24hUP) &gt; 700 mg/day at 8 months is a risk factor for progression renal deterioration [2]. Currently, management proteinuria these an unmet need; use...

<h3>Background:</h3> Pulmonary arterial hypertension (PAH) is one of the main causes mortality in patients with systemic sclerosis (SSc). Its prevalence ranges between 13 and 35% echocardiography 8 12% right heart catheterization (RHC), which gold standard for its diagnosis. Currently, SSc-PAH screening based on consensus recommendations from European Society Cardiology/European Respiratory (ESC/ERS), Australian Scleroderma Interest Group (ASIG), DETECT algorithms. These approaches have been...

<h3>Background:</h3> Established Seronegative Rheumatoid Arthritis (SNRA) was considered a mild form of the disease with good response to therapy on past¹. Lately evidence indicates this arthritis in early stage is serious and should not be underestimated terms activity radiographic damage². By other hand SNRA presents shorter symptoms duration different compare seropositive (SP) patients^3,4. At present, influence seronegative (SN) status clinical course...

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder that disproportionally affects women, especially in their reproductive years. SLE associated with considerable pregnancy-related morbidity, including fetal loss, preterm birth and preeclampsia. Multiple factors are adverse pregnancy outcomes ethnicity, renal involvement glucocorticoid exposure prior to the (1,2). The vary among patients from different ethnic backgrounds. Few studies have been...

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder that disproportionally affects women and known to occur rarely in men. This difference may be explained by estrogenic effect ethnicity. Clinical outcomes including renal involvement, disease activity, damage accrual mortality seem more severe males (1,2). These factors associated with adverse vary among patients from different ethnic backgrounds (1,2,3). Few studies have been performed Mexican...

<h3>Background</h3> The Anti Tumour Necrosis Factor (aTNF) therapy in Rheumatics Diseases (RD) had changed the prognosis of theses conditions last decade. Unfortunately, aTNF is associated a high-risk rate infections, especially active tuberculosis (TB) [1]. use tuberculin skin test (TST) to detect and treat latent (LTBI) before initiate reduced risk TB by 75 95% [2]. However, multiple factors as prevalence country, malnutrition, anergy, immunosuppressors, advanced age, BCG vaccination...

Systemic sclerosis associated-interstitial lung disease (SSc-ILD) show a high mortality. The factors associated SSc-ILD have shown variability in different populations. There are few studies Mexican mestizos.To analyze the epidemiological, clinical and paraclinical with SSc-ILD.Cross-sectional study, where patients > 18 years of age diagnosis SSc according to EULAR/ACR 2013 criteria ILD by forced vital capacity (FVC) < 70% 5% affected area on tomography were included. strength association...

<h3>Background</h3> Neuropsychiatric involvement of systemic lupus erythematosus (NPSLE) is one the most deleterious complications disease, leading to great decrease quality life and poor prognosis [1]. Factors such as activity disease have been associated NPSLE [1,2]. The current treatment remains mostly empiric, requiring high-dose corticosteroids extensive immunosuppressive therapy [3,4]. Short-term efficacy treatments in evaluated by several studies, however few studies performed...

<h3>Background</h3> Established Seronegative Rheumatoid Arthritis (ESNRA) is considered a mild form of the disease with good prognosis and response to therapy compared seropositive (SP) [1]. Lately evidence indicates that seronegative (SN) arthritis in early stage serious should not be underestimated terms activity, radiographic damage [2,3,4]. At present, influence SN status clinical course treatment choice very stages, other words less than 3 months from time at onset disease, still...

Background Spondyloarthritis (SpA) is a set of auto-immune and auto-inflammatory diseases that share similar manifestations axial spine sacroiliac, peripheral joint including oligoarthritis predominantly lower limbs, dactylitis, enthesitis fasciitis, extraarticular involvement eyes, skin, nails, bowel the presence high c-reactive protein (CRP) levels Human Leucocyte Antigen (HLA)-B27 seropositivity. Peripheral such tarsitis (mid-foot arthritis) has been reported associated to ankle...

Background: Lupus nephritis (LN) remaining as one of the most devastating manifestations systemic lupus erythematosus (SLE). Only 60% patients with LN achieve a complete (CR) or partial remission (PR) mycophenolate mofetil (MMF) intravenous (iv) cyclophosphamide (CY) plus corticosteroids. Of those nearly one-half will have relapse following maintenance therapy [1]. Rituximab (RTX) is considered treatment relapsing [2]. Although potential benefits been revealed in descriptive studies,...

Background: Rheumatoid Arthritis (RA) is a disabling chronic inflammatory disease that shows an unpredictable and severe clinical course [1]. Global assessment, functional status activity of patients with RA can be influenced also by non-inflammatory factors as concomitant presence fibromyalgia (FM) [1,2]. FM occur up to 20% in patients, who present widespread pain, fatigue cognitive symptoms impacts achieving complete remission, having more comorbidities, bearing higher medical cost finally...