A5019692263- Inflammation biomarkers and pathways
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Muscle and Compartmental Disorders
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Dermatological and COVID-19 studies
- T-cell and B-cell Immunology
- Inflammatory Myopathies and Dermatomyositis
- Apelin-related biomedical research
- Kawasaki Disease and Coronary Complications
University of Puerto Rico, Medical Sciences Campus
2013-2018
Cryoglobulinaemic vasculitis is characterised by immunoglobulin deposition at low temperatures. The most common manifestations are cutaneous involvement, arthralgias, Raynaud's phenomenon, peripheral neuropathy and renal disease. Myopathy unusual only a few cases have been reported. Here, we present 31-year-old woman who developed progressive muscle weakness involving upper lower extremities, dysphagia, paraesthesias palpable purpura. Diagnostic studies revealed elevated creatine kinase,...
The soluble triggering receptor expressed on myeloid cells (TREM-1)-like transcript 1 (sTLT-1) has a modulatory effect the activation of TREM-1. We compared plasma sTLT-1 levels between patients with systemic lupus erythematosus (SLE) and healthy individuals determined association clinical features patient-reported outcomes (PROs) among lupus.An unmatched case-control study was conducted in 46 SLE 28 subjects. were using enzyme-linked immunosorbent assay. Demographic factors, manifestations,...
Objective: To determine patient-reported outcomes measures in indigent patients with systemic lupus erythematosus receiving their healthcare through the Puerto Rico government managed care system and compare these non-indigent treated a private fee-for-service setting. Methods: A cross-sectional study was conducted cohort of 98 Ricans erythematosus. Patients from public group (n = 40) were university-based specialized clinic 58) community-based rheumatology practice. Demographic clinical...
Glucocorticoid sensitivity can be measured in vitro using the lymphocyte assay (LSA). In this test, dexamethasone is used to inhibit proliferation of peripheral blood mononuclear cells (PBMC) response mitogens. If PBMC suppressed subjects are considered GC sensitive; if not, they resistant. The LSA has been test some inflammatory diseases but its clinical value systemic lupus erythematosus (SLE) not determined. Herein, we present results from two sisters with SLE who had different disease...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune system hyperactivity and autoantibody production that can affect almost any organ system. TREM like transcript-1 (TLT-1) a membrane receptor found in platelets α-granules with activating properties. We have demonstrated activated release soluble isoform of TLT-1 (sTLT-1) which not the plasma healthy individuals. Moreover, evaluation patients suffering from inflammatory diseases, such as sepsis, reveals...