A5048739950- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Health and Lifestyle Studies
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Whipple's Disease and Interleukins
- Obesity, Physical Activity, Diet
- Lipid metabolism and disorders
- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
- Diet, Metabolism, and Disease
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Cholesterol and Lipid Metabolism
- Diabetes Treatment and Management
- Biomarkers in Disease Mechanisms
- Air Quality and Health Impacts
- Protease and Inhibitor Mechanisms
- Peroxisome Proliferator-Activated Receptors
- SARS-CoV-2 and COVID-19 Research
Instituto Nacional de Cardiología
2016-2025
Secretaria de Salud
2006-2022
Instituto Nacional de Cardiologia
2020
El Colegio de México
2017-2018
Universidad Nacional Autónoma de México
2009
Amsterdam UMC Location University of Amsterdam
2007
Stroke Association
2007
Medical Research Council
2007
British Heart Foundation
2007
Food Standards Agency
2007
ABCA1 genetic variation is known to play a role in HDL-C levels and various studies have also implicated cardiovascular risk. The functional ABCA1/R230C variant frequent the Mexican population has been consistently associated with low concentrations. Although it other risk factors such as obesity type 2 diabetes mellitus, not whether coronary artery disease (CAD).The purpose of study was analyze premature CAD case-control association (GEA or Genetics Atherosclerotic Disease), explore BMI...
Experimental studies have shown that high free fatty acid (FFA) and low adiponectin (ADIPO) levels are involved in the mechanisms by which adiposity promotes insulin resistance (IR). However, no previous clinical simultaneously analysed relative contribution of FFA ADIPO on relation abdominal visceral fat (AVF) with resistance. To analyse (adiponectin < =p25th: 8.67 μg/mL women 5.30 men), FFAs (FFAs > =p75th: 0.745 mEq/L 0.60 men) to association AVF (AVF 127 cm2 women; 152.7 (HOMA-IR =75th:...
A microfluidic device to quantitate antibody reactivities SARS-CoV-2 antigens: spike protein, RDB, S1 subunit, and nucleocapsid, from 50 serum samples.
Introduction Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection triggers inflammatory clinical stages that affect the outcome of patients with coronavirus disease 2019 (COVID-19). Disease severity may be associated a metabolic imbalance related to amino acids, lipids, and energy-generating pathways. The aim this study was characterize profile acids acylcarnitines in COVID-19 patients. A multicenter, cross-sectional carried out. total 453 individuals were classified by...
Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim present study was to establish if polymorphisms IL-12A and EBI3 genes that encode IL-35 subunits are associated with premature coronary artery disease (CAD) Mexican individuals. were determined 1162 patients CAD 873 controls. Under different models, rs428253 (OR = 0.831, Padd 0.036; OR 0.614, Prec 0.033; 0.591, Pcod2 0.027) rs2243115 0.674, 0.010; 0.676, Pdom 0.014; 0.698, Phet 0.027;...
Coronary artery calcium (CAC) improves cardiovascular event prediction. Visceral adipose tissue (VAT) is a cardiometabolic risk factor that may directly or through its related comorbidities determine the obesity-related risk. A clinical VAT estimator could allow an efficient evaluation of We aimed to analyze effect and factors on CAC progression.
To examine low-density lipoprotein (LDL) size, LDL susceptibility to oxidation, and plasma insulin levels in children with systemic lupus erythematosus (SLE).Fifty-nine SLE patients 59 healthy, age-matched control subjects were studied. size was determined by gradient gel electrophoresis. oxidizability assessed lag time for conjugated diene formation during copper incubation. Plasma of fasting insulin, glucose, lipids, lipoproteins, apolipoproteins B A-I, fatty acids also measured.Compared...
Background The association of subclinical hypothyroidism (SCH) with insulin resistance, metabolic syndrome (MS), and coronary atherosclerosis is uncertain. Objective To investigate the role increased intrahepatic fat in SCH MS, atherosclerosis. Design, patients, methods We conducted a cross-sectional study sample 753 subjects (46% males) aged 35–70 years no history diabetes, renal, hepatic, thyroid, or heart disease, were participants Genetics Atherosclerotic Disease study. was defined as...
Serum magnesium is inversely associated to coronary artery calcification (CAC) in patients with chronic kidney disease. There little information on this association a general healthy population. The aim of study was examine the cross-sectional serum levels CAC. We included 1276 Mexican-mestizo subjects (50 % women), aged 30–75 years, free symptomatic cardiovascular CAC quantified by multidetector computed tomography using method described Agatston. Cross-sectional associations...
Cardiovascular diseases (CVD) are group of complex and multifactorial pathologies, in which interleukin-6 (IL-6) gene polymorphisms have been associated with several components the CVD. Thus, this study, we thoroughly reviewed meta-analyzed evidence on association between IL-6 (rs1800795) polymorphism We systematically searched PubMed, Web Sciences, Scopus databases. The analyses were performed using five study groups based (1) a combined pool overall populations, (2) country birth, (3)...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a public health problem lacking an approved pharmacological treatment. Omega-3 acids have shown to reverse NAFLD. Chia seed rich in α-linolenic acid (ALA), antioxidants, and fiber; therefore, it could be useful treat Methods In single arm experimental design study, the effect of 25 g/day milled chia was assessed patients with After two weeks dietary stabilization (basal condition) eight chia-supplemented isocaloric diet,...
SARS-CoV-2 uses the ACE2 receptor and cellular protease TMPRSS2 for entry into target cells. The present study aimed to establish if polymorphisms are associated with COVID-19 disease. included 609 patients confirmed by RT-PCR test 291 individuals negative infection without antibodies anti-SARS-CoV-2. Four (rs12329760, rs2298659, rs456298, rs462574) were determined using 5′exonuclease TaqMan assays. Under different inheritance models, rs2298659 (pcodominant2 = 0.018, precessive 0.006,...
Abstract Background Visceral adipose tissue (VAT) has been related to coronary artery disease (CAD), but its association with recurrent major adverse cardiovascular events (MACE) in premature CAD (pCAD) not fully explored. Thus, we aimed investigate the impact of VAT on MACE patients pCAD. Methods This was a retrospective sub-analysis 853 pCAD from GEA cohort study. measured by computed tomography at baseline. The primary outcome recurrence over 5 years follow-up. Likewise, non-fatal and...
La enfermedad arterial coronaria es un padecimiento crónico y multifactorial, considerado problema de salud en el mundo. En su desencadenamiento participan factores ambientales genéticos. Diversos estudios, incluyendo los del genoma completo genes candidatos, han sugerido la participación múltiples desarrollo esta patología. Sin embargo, mayoría estas investigaciones se ha realizado poblaciones caucásicas orientales. Se identificado que mexicanos presentan una mezcla caucásicos, indígenas...
Dipeptidyl peptidase-4 (DPP4) concentrations are known to correlate with nonalcoholic fatty liver (FL), which is also associated subclinical atherosclerosis (SA). This study aimed determine whether DPP4 and the rs17574 polymorphism FL in individuals SA. The included 378 participants SA, of whom 143 had 235 did not. serum were measured using a Bioplex system, genotypes determined TaqMan assays. Logistic regression was used assess relationships between FL, concentrations, genotypes. Overall,...
A growing body of evidence suggests that psychological stress is an independent cardiovascular risk factor. Obesity prevalence shows accelerating trends worldwide, and known to be associated with a range comorbidities survival. The aim this study was assess the relationship between self-perceived parameters adiposity, metabolic syndrome, subclinical atherosclerosis in Mexican participants.Metabolic Syndrome defined using Adult Treatment Panel III criteria, obesity as BMI >30, disease...
Several studies suggest an important role of Interleukin-27 in the development atherosclerosis. The aim this study was to establish whether IL-27p28 gene polymorphisms are associated with premature coronary artery disease and/or other cardiovascular risk factors. Four were selected and genotyped 1162 cases 1107 controls. rs26528 T rs40837 A alleles significantly a lower under different inheritance models (Pdominant = 0.046; Pover-dominant 0.002; Pco-dominant1 0.007 for rs26528T; 0.008 0.031...
Differences in the prevalence of four diabetes subgroups have been reported Mexico compared to other populations, but factors that may contribute these differences are poorly understood. Here, we estimate and evaluate their correlates with indicators social disadvantage using data from national representative surveys.