A5056222002- Nuclear Structure and Function
- Muscle Physiology and Disorders
- Sperm and Testicular Function
- Polyamine Metabolism and Applications
- Telomeres, Telomerase, and Senescence
- Reproductive Biology and Fertility
- Ion channel regulation and function
- Cellular transport and secretion
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Gout, Hyperuricemia, Uric Acid
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Silk-based biomaterials and applications
- Pharmacological Effects of Natural Compounds
- Nutrition and Health in Aging
- Long-Term Effects of COVID-19
- Osteoarthritis Treatment and Mechanisms
- Immune Response and Inflammation
- RNA Research and Splicing
- Sepsis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Ovarian function and disorders
- Adipose Tissue and Metabolism
- Proteoglycans and glycosaminoglycans research
Instituto Nacional de Rehabilitación
2022-2024
Secretaria de Salud
2022-2023
Instituto Politécnico Nacional
2019-2021
Center for Research and Advanced Studies of the National Polytechnic Institute
2017-2020
Introduction Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection triggers inflammatory clinical stages that affect the outcome of patients with coronavirus disease 2019 (COVID-19). Disease severity may be associated a metabolic imbalance related to amino acids, lipids, and energy-generating pathways. The aim this study was characterize profile acids acylcarnitines in COVID-19 patients. A multicenter, cross-sectional carried out. total 453 individuals were classified by...
During a viral infection, the immune response is mediated by toll-like receptors and myeloid differentiation Factor 88 (MyD88) that play an important role sensing infections such as SARS-CoV-2 which has claimed lives of more than 6.8 million people around world. We carried out cross-sectional with population 618 SARS-CoV-2-positive unvaccinated subjects further classified based on severity: 22% were mild, 34% severe, 26% critical, 18% deceased. Toll Like Receptor 7 (TLR7) single-nucleotide...
Nuclear β-dystroglycan (β-DG) is involved in the maintenance of nuclear architecture and function. Nonetheless, its relevance defined processes remains to be determined. In this study we generated a C2C12 cell-based DG-null model using CRISPR-Cas9 technology provide insights into role β-DG on processes. Since cells exhibited decreased levels lamin B1, aimed elucidate contribution DG senescence, owing central B1 pathway. Remarkably, lack enables acquire senescent features, including...
Abstract β-dystroglycan (β-DG) is a key component of multiprotein complexes in the plasma membrane and nuclear envelope. In addition, β-DG undergoes two successive proteolytic cleavages that result liberation its intracellular domain (ICD) into cytosol nucleus. However, stimuli-inducing ICD cleavage physiological relevance this fragment are largely unknown. study we show for first time targeted to nucleolus where it interacts with proteins B23 UBF (central factor Pol I-mediated rRNA gene...
Polyamines are ubiquitous polycationic compounds that highly charged at physiological pH. While passing through the epididymis, sperm lose their capacity to synthesize polyamines and, upon ejaculation, again come into contact with contained in seminal fluid, unleashing events improve motility and capacitation. In present work, we hypothesize about influence of polyamines, namely, spermine, spermidine, putrescine, on activity channels, evaluating intracellular concentrations chloride [Cl−]i,...
The preservation of the chondrogenic phenotype and hypoxia-related physiological microenvironment are major challenges in 2D culture primary human chondrocytes. To address this problem, we develop a 3D system generating scaffold-free spheroids from Our results highlight potential cultured articular chondrocytes combined with hypoxia independently cartilage source. After 14 days culture, developed homogenous diameter shape hyaline donors. Spheroids generated showed significantly increased...
Polyamines are polycationic molecules which contains two or more amino groups (-NH3+) highly charged at physiological pH, and among them we found spermine, spermidine, putrescine, cadaverine. They interact with proteins, nucleic acids, modulate Ca2+, K+, Na+ channels, protect sperm from oxidative stress. In this work, evaluate the effect of putrescine on total, progressive kinematic parameters motility, capacitation, acrosome reaction, also in presence absence dbcAMP, an analogue cAMP, IBMX,...