A5040442014- Antibiotic Resistance in Bacteria
- Orthopedic Infections and Treatments
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Orthopaedic implants and arthroplasty
- Antimicrobial Resistance in Staphylococcus
- Pharmaceutical and Antibiotic Environmental Impacts
- Surgical site infection prevention
- Antimicrobial Peptides and Activities
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Infections and bacterial resistance
- Antibiotics Pharmacokinetics and Efficacy
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
- Total Knee Arthroplasty Outcomes
- Burn Injury Management and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Long-Term Effects of COVID-19
- Antifungal resistance and susceptibility
- Sepsis Diagnosis and Treatment
- Wound Healing and Treatments
Instituto Nacional de Rehabilitación
2016-2025
Durango Institute of Technology
2021-2023
Secretaria de Salud
2022
London School of Hygiene & Tropical Medicine
2017
University of London
2017
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current disease 2019 (COVID-19) pandemic, affecting more than 219 countries and causing death of 5 million people worldwide. The genetic background represents a factor that predisposes way host responds to SARS-CoV-2 infection. In this sense, variants ACE ACE2 could explain observed interindividual variability COVID-19 outcomes. order improve understanding how are involved in severity COVID-19, we included...
Aim: This study aims to assess the changes in antimicrobial resistance among some critical and high-priority microorganisms collected previously during coronavirus disease 2019 (COVID-19) pandemic Mexico. Methods: We susceptibility data for from blood, urine, respiratory samples, all specimens, which pathogen may be considered a causative agent. Data were stratified compared two periods: versus 2020 second semester (prepandemic) (pandemic). Results: In analysis of 2020, blood increased...
We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens epidemiological importance 47 Mexican centers.In this retrospective study, we included a stratified sample centers, covering 20 states. Selected isolates considered as potential causatives disease collected over 6-month period were included. Laboratories employed their usual methods perform microbiological studies. The results deposited into database and analyzed with WHONET 5.6 software.In total...
Abstract Pseudomonas aeruginosa is one of the most worrisome infectious bacteria due to its intrinsic and acquired resistance against several antibiotics recalcitrance infections; hence, development novel antimicrobials effective multidrug-resistant P. mandatory. In this work, silver nanoparticles obtained by green synthesis using a leaf extract fungi were tested battery clinical strains from cystic fibrosis, pneumonia burnt patients, some them with multidrug resistance. Both showed potent...
Background Bacteriophage therapy is becoming part of mainstream Western medicine since antibiotics clinical use tend to fail. It involves applying lytic bacteriophages that self-replicate and induce cell lysis, thus killing their hosts. Nevertheless, bacterial promotes the selection resistant clones which sometimes may exhibit a decrease in virulence or antibiotic resistance. Methods In this work, we studied Pseudomonas aeruginosa phage φDCL-PA6 its variant φDCL-PA6α. Additionally,...
This report presents phenotypic and genetic data on the prevalence characteristics of extended-spectrum β-lactamases (ESBLs) representative carbapenemases-producing Gram-negative species in Mexico.A total 52 centers participated, 43 hospital-based laboratories 9 external laboratories. The distribution antimicrobial resistance for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, Acinetobacter baumannii Pseudomonas aeruginosa selected clinical specimens from January 1 to...
Infections caused by Stenotrophomonas maltophilia and related species are increasing worldwide. Unfortunately, treatment options limited, whereas the antimicrobial resistance is increasing.
Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over world. However, genome identity lineages this species in Latin America not been studied as much developed countries. Here, through population genomics approach considering whole genomes 148 isolates (almost 40 from Mexico and Honduras), we describe recent emergence lineage sequence type 758 (ST758), which belongs to international clone V spread out Canada,...
Background: Surveillance of antimicrobial resistance (AMR) requires an international approach with national and local strategies. Our aim was to summarize a retrospective 10-year report antibiotic gram-positive gram-negative bacteria in Mexico. Methods: A total 46 centers from 22 states Mexico participated. Databases AMR January 2009 December 2018 were included for most species. The period divided into five 2-year periods. Results: For Staphylococcus aureus, decrease all specimens observed...
The identification of carbapenemase-producing Enterobacterales and Pseudomonas aeruginosa is important for treating controlling hospital infections. recommended methods their require a long waiting time, technical training, expertise. Lateral flow immunoassays such as NG-Test CARBA 5® overcome these needs. We analyzed 84 clinical isolates carbapenem-resistant P. from four different hospitals in two-year period. Antimicrobial resistance patterns were confirmed with the broth dilution method....
Introduction The methicillin-resistant Staphylococcus aureus (MRSA) genome varies by geographical location. This study aims to determine the genomic characteristics of MRSA using whole-genome sequencing (WGS) data from medical centers in Mexico and explore associations between antimicrobial resistance genes virulence factors. Methods included 27 clinical isolates collected sterile sites at eight 2022 2023. Antibiotic susceptibility testing was performed VITEK 2. In addition, WGS a NovaSeq...
Background: Trueperella bernardiae is a Gram‐positive rod that has been described as an opportunistic pathogen in immunocompromised patients. In significant number of documented cases, infections with have associated polymicrobial infections, which highlight the fact important bacteria–bacteria relations might be involved natural course these especially patients chronic disease courses and history multiple antibiotic treatments. Case Presentation: We present case 24‐year‐old woman 3‐year...
Stenotrophomonas maltophilia is the species most frequently identified by clinical microbiology laboratories due to its presence in main identification systems databases. Phenotypic methods are widely used laboratories, and misidentification of spp. highly probable cryptic species. Our aim was confirm identity five cefiderocol-resistant species, initially as S. maltophilia, using genome analysis tools, performing comparative functional analyses these strains associated with infectious...
Introduction Antimicrobial resistance surveillance plays an important role in generating information about the prevalence of resistant microorganisms. In this study, we summarize a antimicrobial and carbapenemase-encoding genes for selected pathogens Mexican healthcare centers. Methods Databases identification susceptibility results collected from January 1 to March 31, 2024, forty-one centers were gathered analyzed using WHONET software. Some relevant gram-negatives gram-positives, which...
Pseudomonas aeruginosa is an opportunistic bacterium associated with healthcare infections in intensive care units, ventilator-associated pneumonia, surgical site and burns. This causes 75% of death burned patients, since it can develop a persistent biofilm infections, express several virulence factors antibiotic-resistance mechanisms. Some these are proteases such as elastase alkaline protease, or toxic metabolites pyocyanin one the few microorganisms able to produce cyanide, which inhibits...
During a viral infection, the immune response is mediated by toll-like receptors and myeloid differentiation Factor 88 (MyD88) that play an important role sensing infections such as SARS-CoV-2 which has claimed lives of more than 6.8 million people around world. We carried out cross-sectional with population 618 SARS-CoV-2-positive unvaccinated subjects further classified based on severity: 22% were mild, 34% severe, 26% critical, 18% deceased. Toll Like Receptor 7 (TLR7) single-nucleotide...
Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a major public health concern. We aimed to evaluate the prevalence of CR-GNB and frequency carbapenemase-encoding genes in tertiary referral center from El Bajio, Mexico. A cross-sectional study was conducted between January October 2022; (GNB) were screened for vitro resistance at least one carbapenem. further analyzed carbapenemase-production through phenotypical methods by real-time PCR following genes: blaKPC, blaGES, blaNDM,...
We analyzed the antimicrobial resistance (AMR) data of 6519 clinical isolates Escherichia coli (n = 3985), Klebsiella pneumoniae 775), Acinetobacter baumannii 163), Pseudomonas aeruginosa 781), Enterococcus faecium 124), and Staphylococcus aureus 691) from 43 centers in Mexico. AMR assays were performed using commercial microdilution systems (37/43) disk diffusion susceptibility method (6/43). The presence carbapenemase-encoding genes was assessed PCR. Data regarding site care, patient age,...
As options to treat recalcitrant bacterial infections which are increasingly limited due multidrug-resistant strains, searching for new, effective antibacterial compounds is necessary. One strategy generate treatment alternatives by drug repurposing.In this work, phenotypic microarrays were used the screening of miscellaneous against growth and biofilm formation Acinetobacter baumannii, an important emergent opportunistic pathogen. The results showed that phenothiazine derivatives, such as...
Fosfomycin is currently a viable option against urinary tract infections, particularly extended-spectrum β-lactamases (ESBL)-producing E. coli, due to its unique mechanism of action and low resistance among bacteria. The objective this study was investigate two the three most common mechanisms antibiotic 350 ESBL-producing coli strains isolated from urine Mexican patients. prevalence fosfomycin in our 10.9% (38/350). Of all resistant isolates analyzed, 23 (60.5%) were identified as...