A5088168825- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Macrophage Migration Inhibitory Factor
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Nuclear Receptors and Signaling
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Protein Tyrosine Phosphatases
- Immune Response and Inflammation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Inflammasome and immune disorders
- Salivary Gland Disorders and Functions
- Diet, Metabolism, and Disease
Universidad de Guadalajara
2016-2025
Debre Markos University
2023
Medical University of Białystok
2023
Chung-Ang University
2023
Institut für Bahntechnik (Germany)
2023
Instituto de Investigaciones en Ciencias de la Salud
2016-2021
Mexican Social Security Institute
2019
Hospital de Especialidades
2019
Hospital Civil de Guadalajara
2009-2017
University of the Valley of Atemajac
2017
Abstract Over the last 500 years, admixture among Amerindians, Europeans, and Africans, principally, has come to shape present‐day gene pool of Mexicans, particularly Mestizos, who represent about 93% total Mexican population. In this work, we analyze genetic data 13 combined DNA index system‐short tandem repeats (CODIS‐STRs) in 1,984 unrelated Mestizos representing 10 population samples from different regions Mexico, namely North, West, Central, Southeast. The analysis molecular variance...
B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) signaling pathways regulate B-cell survival through interactions with their receptors BAFF-R, TACI BCMA. We evaluated the association of these ligands/receptors on subsets according to clinical manifestations systemic lupus erythematosus (SLE).BAFF APRIL serum concentrations were measured in 30 SLE patients by enzyme-linked immunosorbent assay. The BCMA expression was analyzed each B cell subset (CD19 + CD27-CD38-/...
Background Several variants of the SARS-CoV-2 have been documented globally during current COVID-19 pandemic. The N501Y, 69-70del, K417N, and E484K mutations among most relevant due to their potential pathogenic biological effects. This study aimed design, validate, propose a fast real-time RT-qPCR assay detect with possible clinical epidemiological relevance in Mexican population. Methods Targeting spike ( S ) gene (N501Y, E484K), specific primers, probes for three quantitative reverse...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current disease 2019 (COVID-19) pandemic, affecting more than 219 countries and causing death of 5 million people worldwide. The genetic background represents a factor that predisposes way host responds to SARS-CoV-2 infection. In this sense, variants ACE ACE2 could explain observed interindividual variability COVID-19 outcomes. order improve understanding how are involved in severity COVID-19, we included...
The n-3 polyunsaturated fatty acids (PUFAs) can reduce inflammatory markers and may therefore be useful in obesity management. aim of this study was to analyze the effect supplementation with PUFAs on total acid profile red blood cells (RBCs), as well biochemical markers, subjects obesity. consisted a randomized placebo-controlled, double-blind clinical trial involving 41 during 4-month follow-up. Individuals were randomly assigned two groups: PUFA (1.5 g fish oil) placebo sunflower oil)....
Studies have noted the connection between Mycobacterium avium subspecies paratuberculosis (MAP) and autoimmunity. MAP is an intracellular pathogen that infects multiplies in macrophages. To overcome hostile environment elicited by macrophage, secretes a battery of virulence factors to neutralize toxic effects macrophage. One Protein Tyrosine Phosphatase A (PtpA), protein secreted interferes phago-lysosome fusion, rendering unnoticed cytoplasm This study aimed assess presence PtpA antibodies...
Diet is an important environmental factor that interacts with genes to modulate the likelihood of developing disorders in lipid metabolism and relationship between diet presence other chronic diseases such as obesity. The objective this study was analyze interaction a high fat APOA2 (rs3813627 rs5082), APOA5 (rs662799 rs3135506) LEPR (rs8179183 rs1137101) polymorphisms its obesity dyslipidemia young subjects. included 200 subjects aged 18 25 years (100 normal-weight 100 obese subjects)....
The main expected result of a vaccine against viruses is the ability to produce neutralizing antibodies. Currently, several vaccines SARS-CoV-2 are being applied prevent mortal complications, Pfizer-BioNTech (BNT162b2) one first be authorized in USA and Mexico (11 December 2020). This study evaluated efficacy this on antibody production with capacity its side effects healthcare workers without prior infection group unvaccinated individuals COVID-19. findings 100% antibodies both groups after...
The immunomodulatory effects of vitamin D are known to be beneficial in viral infections; it is also that its deficiency associated with a prognosis more critical Coronavirus Disease 2019. This study aimed determine baseline serum concentrations and the supplementation asymptomatic or mildly symptomatic 2019 outpatients.
Summary Antibodies against cyclic citrullinated peptides (anti-CCP) are widely used for diagnosis of rheumatoid arthritis (RA). We performed a comparative analysis antibodies targeting the citrullinating enzyme peptidylarginine deiminase type 4 (anti-PAD4) and mutated vimentin (anti-MCV) with anti-CCP autoantibodies in RA patients examined their relationships clinical parameters, cytokine profiles PADI4 gene. Autoantibodies were by enzyme-linked immunosorbent assay (ELISA) sera 170 103...
Obesity and nutrients intake deficiencies may contribute to the clinical manifestations inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was assess relationship between nutritional status dietary with variables Mexican-mestizo SLE patients. A cross-sectional conducted 130 female patients, classified by 1997 American College Rheumatology (ACR) criteria; activity evaluated Mexican-Systemic Lupus Erythematosus-Disease Activity Index (Mex-SLEDAI); body mass...