A5028521592- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Infant Nutrition and Health
- Galectins and Cancer Biology
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Nutritional Studies and Diet
- Autoimmune Bullous Skin Diseases
- Endodontics and Root Canal Treatments
- IL-33, ST2, and ILC Pathways
- Dupuytren's Contracture and Treatments
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 detection and testing
- Child Nutrition and Water Access
- Phytoestrogen effects and research
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Psoriasis: Treatment and Pathogenesis
Universidad de Guadalajara
2016-2025
Debre Markos University
2023
Medical University of Białystok
2023
Chung-Ang University
2023
Institut für Bahntechnik (Germany)
2023
Universidad Autónoma de Guerrero
2015
Plaque psoriasis (PP) is a chronic immune-mediated skin disorder with genetic basis, characterized by abnormal T-cell responses. This study investigated the role of FOXP3 gene variants rs2280883 and rs3761548 in regulation through their effects on IL-10 TGF-β1 cytokine levels association PP risk. A case-control was conducted, including 101 individuals 106 healthy controls from Mexican population. Genotyping performed using PCR-RFLP, were measured ELISA kits. Significant differences allele...
Rheumatoid Arthritis (RA) is a multifactorial autoimmune disease. Currently, several genes play an important role in the development of The objective was to evaluate association STAT4 rs7574865 and rs897200 gene variants with RA susceptibility, DAS28, RF, anti-CCP Western Southern Mexico populations. Genotyping performed on 476 samples (cases = 240; controls 236) using Taqman® system qPCR probes. Disease activity assessed DAS28 HAQ DI. CRP, ESR, were determined for clinical assessment. Our...
The inflammatory process implicates homeostasis disruption and increased production of mediators. Myeloid differentiation primary response 88 (MyD88) is an essential protein recruited after lipopolysaccharide (LPS) interleukin (IL)-1β stimulation, a that converges in nuclear factor kappa B (NF-κB) activation, as well transcription several genes both pro- anti-inflammatory cytokines. inhibition MyD88 has shown efficacy by decrease response, demonstrated potential application therapeutic...
Background. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes disease 2019 (COVID-19). It estimated more than half of new infections are transmitted by asymptomatic people; therefore, isolation symptomatic people not enough to control spread disease. Methods. A total 171 unvaccinated young adults (18–35 years) from Sonora, Mexico, who underwent a structured survey identify prior COVID-19 infections, were included in this study. qualitative determination...
We aim to identify Th1 and Th2 cell clusters in young subjects, including their clinical metabolic characteristics the Th1/Th2 balance.A total of 100 participants were included. The frequencies cells peripheral blood determined by flow cytometry. Serum C-reactive protein was measured using a turbidimetric assay, insulin levels quantified with an enzyme-linked immunosorbent assay. Circulating cytokine analyzed multiplex system.A cluster analysis performed determine balance group people, 3...
Macrophage migration inhibitory factor (MIF) significantly contributes to rheumatoid arthritis (RA) pathogenesis. We aimed evaluate the canonical (CD74/CD44) and non-canonical MIF receptors (CXCR2,4 7) expression sCD74 establish their association with RA clinical activity according DAS28-ESR.101 patients different activities (remission (n = 27), low 16), moderate 35) high 23)) 9 control subjects (CS) were included. Expression was evaluated by flow cytometry levels of soluble CD74 (sCD74)...
Satiety and appetite-stimulating hormones play a role in the regulation of food intake. Breastfed infants may have different profile serum appetite-regulating than formula-fed infants. We propose to demonstrate that concentration appetite regulatory differs according type feeding there is correlation between concentrations these mothers at 4 months age. In cross-sectional analysis, 167 mother-newborn dyads Hospital Civil de Guadalajara were enrolled: 74 full breastfeeding (FBF), 56 partial...
We analyzed the relationship of −794<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>CATT</mml:mtext></mml:mrow><mml:mrow><mml:mn>5</mml:mn><mml:mtext>–</mml:mtext><mml:mn>8</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>and −173 G>C MIF polymorphisms with mRNA and soluble in young obese subjects. A total 250 subjects, 150 normal-weight 100 were recruited study. Genotyping...
Helicobacter pylori promotes the secretion of cytokines that regulate inflammation and carcinogenesis. Immune cells secrete into extracellular medium or packaged in exosomes. The objective this study was to analyze profile soluble exosomal were secreted by human peripheral blood mononuclear (PBMCs) infected with H. build a network interaction between cellular proteins. PBMCs obtained density gradient centrifugation for 24 h. infection verified immunofluorescence Western blot CagA. exosomes...
Abstract It has been accepted that satiety‐ and appetite‐stimulating hormones play a role in the regulation of food intake body composition during after lactation stage. Therefore, purpose was to demonstrate serum appetite‐regulating infants differ according anthropometric indicators type feeding. In nonrandom cohort study, 169 mother–newborn dyads whose pregnancy birth were attended at Hospital Civil de Guadalajara enrolled. According feeding, classified as full breastfeeding (FBF), partial...
Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine that plays a crucial role as regulator of the innate and adaptive immune responses takes part in destructive process joint rheumatoid arthritis (RA) by promoting angiogenesis inducing proinflammatory cytokines matrix metalloproteinases (MMP). We evaluated if recombinant human MIF (rhMIF) induces production TNF-α, IFN-γ, IL-1β, IL-6, IL-10, IL-17A, IL- 17F peripheral blood mononuclear cells (PBMC) from RA patients...
Introduction: Prolactin (PRL) is a 23-kDa protein that can be synthesized and secreted by pituitary extrapituitary tissues such as immune cells due to its expression being regulated two independent promoter regions.The which responsible for contains the single nucleotide polymorphism (SNP) -1149 G/T previously associated with autoimmune diseases in various populations.This study evaluates relationship of PRL serum levels clinical characteristics systemic lupus erythematosus (SLE) patients...
Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and destruction RA could be the secretion of other immune-modulatory cytokines such as IL-25, IL-31, IL-33. For above, our main aim was to evaluate IL-33 from recombinant human MIF (rhMIF)-stimulated peripheral blood mononuclear cells (PBMC) patients. The rhMIF lipopolysaccharide...
Abstract Background Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by a lymphocytic infiltrate in salivary glands driving to epithelial damage. The pSS patients present heterogenic clinical and serological characteristics. This heterogenicity could be due the cytokine microenvironment. Cytokine levels have been analyzed reported individually, showing controversial results; for that reason, we considered essential evaluate cluster of cytokines relate them with...
Abstract Background Macrophage inhibitory factor (MIF) is a pro‐inflammatory cytokine secreted by several cells, including those in the immune system and skin. The MIF gene contains SNP ‐173 G> C STR ‐794 CATT 5‐8 polymorphisms promoter region capable of affecting its activity. Our objective was to investigate as risk for plaque psoriasis (PP) Mexican population. Methods We genotyped both polymorphism (rs5844572 rs755622) 224 PP patients with clinical histopathological diagnosis 232...