A5022707423- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Macrophage Migration Inhibitory Factor
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
- Diabetes and associated disorders
- Protein Tyrosine Phosphatases
- Lymphoma Diagnosis and Treatment
- Dupuytren's Contracture and Treatments
- Immune Response and Inflammation
- Protease and Inhibitor Mechanisms
- Nuclear Receptors and Signaling
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
- Urticaria and Related Conditions
- Natural product bioactivities and synthesis
- TGF-β signaling in diseases
- Spondyloarthritis Studies and Treatments
- Invertebrate Immune Response Mechanisms
- 14-3-3 protein interactions
- Phytochemical compounds biological activities
Universidad de Guadalajara
2014-2024
Abstract Background Persistent high risk HPV infection can lead to cervical cancer, the second most common malignant tumor in women worldwide. NK cells play a crucial role against tumors and virus-infected through fine balance between activating inhibitory receptors. Expression of triggering receptors NKp30, NKp44, NKp46 NKG2D on correlates with cytolytic activity cells, but these have not been studied cancer precursor lesions. The aim present work was study NKp46, NKG2D, NKp80 2B4...
Summary Antibodies against cyclic citrullinated peptides (anti-CCP) are widely used for diagnosis of rheumatoid arthritis (RA). We performed a comparative analysis antibodies targeting the citrullinating enzyme peptidylarginine deiminase type 4 (anti-PAD4) and mutated vimentin (anti-MCV) with anti-CCP autoantibodies in RA patients examined their relationships clinical parameters, cytokine profiles PADI4 gene. Autoantibodies were by enzyme-linked immunosorbent assay (ELISA) sera 170 103...
Rheumatoid Arthritis (RA) is an autoimmune and chronic inflammatory disease of unknown etiology. Killer cell immunoglobulin-like receptors are expressed on the surface natural killer cells CD28null T-cells, both present in synovial membrane RA. Therefore we evaluated associations KIR genes with RA.16 were genotyped 100 healthy subjects (HS) RA patients from Western Mexico using PCR-SSP. Differences genotypes gene frequencies assessed <formula>X^{2}</formula> test.Gene frequency KIR2DL3 was...
Objective : Rheumatoid Arthritis (RA) is an autoimmune and chronic inflammatory disease of unknown etiology. Killer cell immunoglobulin-like receptors are expressed on the surface natural killer cells CD28 null T-cells, both present in synovial membrane RA. Therefore we evaluated associations KIR genes with Methods 16 were genotyped 100 healthy subjects (HS) RA patients from Western Mexico using PCR-SSP. Differences genotypes gene frequencies assessed X 2 test. Results Gene frequency KIR2DL3...
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved presentation. The gene includes IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas soluble concentrations (sCD28) related clinical activity.We investigated 200 patients healthy subjects (HS). Furthermore, we quantified sCD28 77 samples each group. We applied indexes focused determine...
Disease Modifying Anti-Rheumatic Drugs (DMARDs) are aimed to interfere with rheumatoid arthritis (RA) progression and reduce the joint damage; however, not all patients respond alike. Killer-cell immunoglobulin-like receptors (KIR) their ligands, human leucocyte antigen class I (HLA-I), have been associated RA pathology; therefore, KIR HLA genes may influence treatment response.We evaluated association of genotype ligands HLA-C response DMARDs in patients. We included 69 diagnosed 82 healthy...
Objective: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved presentation. The gene includes IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas soluble concentrations (sCD28) related clinical activity. Methods: We investigated 200 patients healthy subjects (HS). Furthermore, we quantified sCD28 77 samples each group. applied indexes...
Introduction . Systemic Sclerosis (SSc) is an autoimmune, inflammatory, and multisystemic disease characterized by the presence of autoantibodies fibrosis. The pathogenesis involves interaction between immune system cells such as macrophages, NK cells, T B cells. Killer-cell Immunoglobulin-like Receptors (KIR) are expressed in some cell subsets that recognize HLA class I molecules ligands involved regulating activation inhibition these KIR family consists 14 genes two pseudogenes; according...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and pro-inflammatory cytokines production. IL-1Ra anti-inflammatory cytokine codified IL1RN gene that blocks IL-1 signalling. A VNTR polymorphism of 86 bp in has been associated with RA risk regulation expression. In this study, we determined mRNA protein expression patients control subjects (CS). This study included 85 classified according to the ACR/EULAR 2010 criteria 67 CS. Polymerase chain reaction was used...
Rheumatoid Arthritis (RA) is characterized by joint destruction, chronic inflammation, and autoantibody production. IL-21/IL-21R plays an essential role in the immunopathology of RA. Elevated IL-21 serum levels have been associated with RA disease activity. Here, we evaluated association polymorphisms The study included 275 patients 280 Control subjects (CSs). Single nucleotide (rs2055979 rs2221903) IL-21R (rs3093301) were genotyped using PCR-RFLP. Clinical activity was DAS28-ESR; anti-CCP...
Macrophage migration inhibitory factor (MIF) and tumor necrosis alpha (TNFα) play a pivotal role in rheumatoid arthritis (RA). MIF is considered relevant cytokine because it appears before TNFα the inflammatory cascade thus stimulating production MIF’s relationship with traditional synthetic disease modifying antirheumatic drugs (sDMARDs) unknown. In this cross-sectional study, we investigated association of serum levels methotrexate (MTX) combination chloroquine (CLQ) sulfasalazine (SSZ) RA...