A5049150142- Breast Cancer Treatment Studies
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- BRCA gene mutations in cancer
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Global Cancer Incidence and Screening
- Advanced Breast Cancer Therapies
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Monoclonal and Polyclonal Antibodies Research
- Macrophage Migration Inhibitory Factor
- Nanoparticle-Based Drug Delivery
- Nutrition, Genetics, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and Medication Impact
- Gold and Silver Nanoparticles Synthesis and Applications
- Pharmacological Effects of Natural Compounds
- Biotechnology and Related Fields
- Cancer, Lipids, and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Angiogenesis and VEGF in Cancer
- IL-33, ST2, and ILC Pathways
Universidad de Guadalajara
2011-2024
Abstract Background Persistent high risk HPV infection can lead to cervical cancer, the second most common malignant tumor in women worldwide. NK cells play a crucial role against tumors and virus-infected through fine balance between activating inhibitory receptors. Expression of triggering receptors NKp30, NKp44, NKp46 NKG2D on correlates with cytolytic activity cells, but these have not been studied cancer precursor lesions. The aim present work was study NKp46, NKG2D, NKp80 2B4...
Abstract Background Cervical cancer is the second most common in women worldwide. NK and cytotoxic T cells play an important role elimination of virus-infected tumor through NKG2D activating receptors, which can promote lysis target by binding to major histocompatibility complex class I-related chain A (MICA) proteins. Increased serum levels MICA have been found patients with epithelial tumors. The aim this study was compare soluble (sMICA) NKG2D-expressing blood samples from cervical or...
MDR1, which is encoded by the ABCB1 gene, involved in multidrug resistance (hydrophobic), as well elimination of xenotoxic agents. The association between gene polymorphisms and breast cancer risk different populations has been described previously; however, results have inconclusive. In this study, we examined 3435 C/T 1236 development Mexican women according to their menopausal status molecular classification. Molecular subtypes allele genotype frequencies were analyzed. A total 248 with...
Islet transplantation has become a widely accepted therapeutic option for selected patients with type 1 diabetes mellitus. However, in order to achieve insulin independence great number of islets are often pooled from 2 4 pancreata donors. Mostly, it is due the massive loss immediately after transplant. The endothelium plays key role function native and during revascularization process islet transplantation. if delayed occurs, even remaining will also undergo cell death late graft...
Molecular profile of breast cancer in Latin-American women was studied five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic molecular subtypes were described, the 60-month overall cumulative survival probabilities (OS) estimated. From 2011 to 2013, 1,300 eligible 18 years or older, with a diagnosis clinical stage II III, performance status ≦̸1 invited participate prospective cohort study. Face-to-face interviews...
Breast cancer is the number one cause of can- cer deaths among Hispanic women in United States, and Mexico, it recently became primary deaths. This malign- nancy represents a poorly understood un- derstudied disease women. The ELLA Binational Cancer Study was es- tablished 2006 as multi-center study to as- sess patterns breast tumor markers, clinical characteristics, their risk factors Mexican descent. We describe design implementation provide factor comparison between U.S. those Mexico...
Natural killer (NK) cells are an important resource of the innate immune system directly involved in spontaneous recognition and lysis virus-infected tumor cells. An exquisite balance inhibitory activating receptors tightly controls NK cell activity. At present, one best-characterized is NKG2D, which promotes NK-mediated target by binding to a family surface ligands encoded MHC class I chain-related (MIC) genes, among others. The goal this study was describe expression pattern MICA MICB at...
Breast cancer mortality rates in Latin America (LA) are higher than those the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The American Cancer Research Network was established to address these challenges and promote collaborative clinical research. Molecular Profiling Study (MPBCS) aimed evaluate characteristics treatment outcomes LA participants with locally breast (LABC).
Abstract Background Functional variants ‐173 G > C (rs755622) and ‐794CATT 5‐8 (rs5844572) MIF gene have been associated with the risk in several types of cancer, as well increase soluble levels TNFα. However, previous studies contradictory uncertain results presented on implication polymorphisms association specifically breast cancer (BC). We investigated whether are susceptibility to develop BC TNFα women from western Mexico. Materials methods A total 152 182 control subjects (CS) were...
Breast cancer (BC) is the leading cause of cancer-related deaths among women in Mexico.Two single-nucleotide polymorphisms (SNPs) thymidylate synthase (TS) gene, 28-base pair (bp) ©FUNPEC-RP www.funpecrp.com.
Purposes Most molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of Latin American population. Searching for similarities differences in molecular pathways associated with these tumors evaluating its impact prognosis may help to select better therapeutic approaches. Patients Methods We collected clinical, pathological, transcriptomic data a multi-country cohort 1,071 stage II-III patients Molecular Profile Breast Cancer...
Introduction: Interleukin-6 (IL-6) is a circulating proinflammatory cytokine that fulfills an important role in the survival and proliferation of cancer cells. Overexpression IL-6, possibly due to −174G>C −596G>A polymorphisms IL6 gene, has been shown be related breast (BC) more aggressive course disease. Aim: To determine influence gene on levels IL-6 BC patients from Jalisco, México. Methodology: Genotyping two was carried out 208 219 healthy controls through polymerase chain...
Several guidelines recommend the use of different classifiers to determine risk recurrence (ROR) and treatment decisions in patients with HR+HER2- breast cancer. However, data are still lacking for their usefulness Latin American (LA) patients. Our aim was evaluate comparative prognostic predictive performance ROR a real-world LA cohort.
Breast cancer (BC) is the leading cause of death from tumors in women worldwide, influenced by various factors, including genetics. The T allele single nucleotide variant (SNV) rs3025039 at position +936 VEGFA gene has been reported to affect mRNA regulatory mechanisms, potentially altering expression and increasing BC risk. This study aimed investigate association between Mexican residing Jalisco, Mexico. included 231 with a confirmed diagnosis 201 healthy subjects as reference group (RG)....
PURPOSE The National Cancer Institute (NCI) Center for Global Health promotes global oncology research to reduce cancer burden worldwide. In 2009, NCI launched the Latin American Research Network (LACRN) support a clinical network in America. LACRN was started by coalition of institutions through bilateral collaborative agreements between US Department and Human Services governments Argentina, Brazil, Chile, Mexico, Uruguay. is supported contract study coordination center subcontracts 6 low-...