A5017309763- Palliative Care and End-of-Life Issues
- Cancer Risks and Factors
- Reproductive System and Pregnancy
- Breast Cancer Treatment Studies
- Pregnancy and preeclampsia studies
- Systemic Lupus Erythematosus Research
- Telemedicine and Telehealth Implementation
- COVID-19 and healthcare impacts
- Maternal and fetal healthcare
- Global Cancer Incidence and Screening
- Cardiovascular Health and Risk Factors
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Gestational Diabetes Research and Management
- Grief, Bereavement, and Mental Health
- Advanced Breast Cancer Therapies
- Birth, Development, and Health
- Family and Patient Care in Intensive Care Units
- Immune Cell Function and Interaction
- Disaster Response and Management
- Maternal and Perinatal Health Interventions
- Telomeres, Telomerase, and Senescence
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Preterm Birth and Chorioamnionitis
Stanford University
2021-2022
American Congress of Obstetricians and Gynecologists
2022
Stanford Health Care
2022
Palo Alto University
2021
Manx National Heritage
2017-2020
University of California, Berkeley
2012-2019
Berkeley Public Health Division
2017
Servicio Aragonés de Salud
2014
Universidade Estadual da Paraíba
2014
University of Arizona
2009-2011
Human fetal T cell activation against maternal antigens could promote uterine contractions in preterm labor.
PURPOSE Testing to measure homologous repair deficiency (HRD) in certain cancers can identify patients who may benefit from poly(ADP-ribose) polymerase inhibitors. We examined real-world patterns and factors associated with testing HRD (eg, BRCA1 / 2 , loss of heterozygosity, genomic instability) epithelial ovarian cancer (EOC) mutations human epidermal growth factor receptor 2–negative metastatic breast (mBC) their prevalence. METHODS described demographic clinical characteristics diagnosed...
OBJECTIVE: To assess concordance and acceptability of a modified menstrual pad compared with clinician-collected high-risk human papillomavirus (HPV) sample. METHODS: This was prospective observational study. Women presenting for either cervical cancer screening or history HPV positivity were eligible. Three samples requested from participants: 1) specimens; 2) self-collected vaginal swabs; 3) pad, which taken home use during the next menstruation. All processed using Cobas test. Menstrual...
Breast cancer is the number one cause of can- cer deaths among Hispanic women in United States, and Mexico, it recently became primary deaths. This malign- nancy represents a poorly understood un- derstudied disease women. The ELLA Binational Cancer Study was es- tablished 2006 as multi-center study to as- sess patterns breast tumor markers, clinical characteristics, their risk factors Mexican descent. We describe design implementation provide factor comparison between U.S. those Mexico...
To investigate whether a child's genotype affects mother's risk of rheumatoid arthritis (RA) beyond the associated with her and to test exposure fetal alleles inherited from father increases RA among mothers without alleles.A case-control study was conducted 1165 (170 cases/995 controls) their respective 1482 children. We tested association between having any child encoding amino acids (AAs) including 'shared epitope' (SE) DERAA AA sequences at positions 70-74; valine, lysine alanine 11, 71...
Leukocyte telomere length (LTL) is a biomarker that affected by older age, psychosocial stress, and medical comorbidities. Despite the relevance of these factors to obstetric practice, little known about LTL in pregnancy. Our study explored longitudinal dynamics pregnant non-pregnant people.This pilot compares changes between people over time, explores potential correlations mental health measures, investigates associations short first-trimester adverse pregnancy outcomes.This was...
Abstract Purpose Standard-of-care for HER2-positive metastatic breast cancer (HER2 + mBC) patients consists of trastuzumab ± pertuzumab with chemotherapy in first-line (1L), and ado-trastuzumab emtansine (T-DM1) or the more recently approved deruxtecan (T-DXd) second-line (2L). Contemporary data on treatment sequencing real-world effectiveness is limited. This study aims to report 2L treatments outcomes among HER2 mBC United States (US). Methods initiating (index date) between January 2014...
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) disproportionately affect women during following childbearing years. Antihuman leucocyte antigen (HLA) alloantibody responses are common in healthy parous women, as these diseases both linked with HLA immune dysregulation, we sought to evaluate anti-HLA antibodies RA SLE.Anti-HLA were measured among SLE cases (n=224), (n=202) controls (n=239) compared each other well nulliparous female male controls. Antibody specificities...
Objective: To investigate the access and communication of deaf adults in health services.Method: A descriptive study conducted from March/2011 to July/2012 a school audio-communication located Campina Grande/Paraiba, Brazil.Participated 36 patients who answered questionnaire about services, data analyzed SPSS.Results: It found that 75% people medical services 88.9% dental service, being public institutions most accessed ones (53.1%).The main factors motivated 25% did not seek were: no need...
Abstract Racial disparity exists for hypertensive disorders in pregnancy (HDP), which leads to disparate morbidity and mortality worldwide. The enzyme heme oxygenase-1 (HO-1) is encoded by HMOX1 , has genetic polymorphisms its regulatory region that impact expression activity have been associated with various diseases. However, studies of these variants HDP limited. objective this study was examine as a potential contributor ancestral seen HDP. First, the 1000 Genomes Project (1 KG) phase 3...
Background: Limited knowledge exists about the drivers of telehealth use among obstetricians during COVID-19 in United States. We investigated live video visits by Maternal-Fetal Medicine (MFM) clinicians, factors associated with and interest future use. Methods: drew survey data from 373 clinicians on two outcomes: (1) any (vs. no) (2) users, extent Bivariate multivariate logistic regressions quantified association between predisposing (demographic practice setting characteristics) enabling...
Abstract Background. Standard-of-care treatment for HER2-positive metastatic breast cancer (HER2+ mBC) patients has traditionally included targeted therapies such as trastuzumab and/or pertuzumab in first line (1L) and ado-trastuzumab emtansine (T-DM1) the second (2L). In 2021, fam-trastuzumab deruxtecan-nxki (T-DXd, Enhertu®) was approved following DESTINY-Breast 03 trial results, demonstrating a significant reduction risk of progression compared to T-DM1 2L. Contemporary data on patterns...
Purpose This case study aims to understand the experience of care from a patient/carer perspective and describe how method can be replicated address gaps in evidence relating integrated person-centred care. Design/methodology/approach The was constructed using data extracted personal diaries medical records kept by person with complex condition, correspondence family last 18 months life interviews carer long-term conditions coordinator. number professionals or teams involved providing...
Purpose Palliative care requires integration between services, organisations and the community. A series of community engagement programmes, named “Listening Events”, were conducted across Isle Man. The aim was to involve in development Hospice strategy by sharing their views on future palliative end life care. Design/methodology/approach Three Listening Event programmes settings, secondary schools Man’s University College. investigators facilitated discussions current knowledge what would...
The study objective was to test the hypothesis that having histocompatible children increases risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing persistence fetal cells acquired during pregnancy. We conducted a case control using data from UC San Francisco Mother Child Immunogenetic Study studies at Inova Translational Medicine Institute. imputed human leukocyte antigen (HLA) alleles minor histocompatibility antigens (mHags). created variable...
<h3>Background</h3> Isle of Man (IOM) is a crown dependency with 83,000 residents. To provide an evidence-base for the strategy on person-centred, palliative and end life care, Hospice carried out needs assessment. Typically this involves quantitative qualitative data describing services identifying gaps. Many sources used purpose in UK (e.g. UK's PopNAT) are not available IOM so we compensated by extensive engagement those working relevant organisations as well public. <h3>Aim</h3> carry...
INTRODUCTION: Globally, cervical cancer is the fourth most common women’s cancer, and second highest cause of cancer-related mortality. High risk human papillomavirus (HR-HPV) testing a potential primary test but conventionally clinic-performed. HR-HPV detection via self-collected samples could increase screening access, reducing opportunity costs uncomfortable visits. A modified menstrual pad (Q-Pad, www.qvin.com/en), offers passive sample collection approach alternative. It has removable...