A5034712994- Breast Cancer Treatment Studies
- Cervical Cancer and HPV Research
- NF-κB Signaling Pathways
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Global Cancer Incidence and Screening
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- BRCA gene mutations in cancer
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Mycobacterium research and diagnosis
- Cancer Risks and Factors
- Homicide, Infanticide, and Child Abuse
- DNA Repair Mechanisms
- Macrophage Migration Inhibitory Factor
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
Universidad de Guadalajara
2014-2024
Hospital Civil de Guadalajara
2009-2024
MDR1, which is encoded by the ABCB1 gene, involved in multidrug resistance (hydrophobic), as well elimination of xenotoxic agents. The association between gene polymorphisms and breast cancer risk different populations has been described previously; however, results have inconclusive. In this study, we examined 3435 C/T 1236 development Mexican women according to their menopausal status molecular classification. Molecular subtypes allele genotype frequencies were analyzed. A total 248 with...
B7-H6 has been revealed as an endogenous immunoligand expressed in a variety of tumors, but not healthy tissues. Heretofore, no studies have reported describing women with cervical cancer. To investigate this question, our present study was conducted.This retrospective comprised total 62 paraffinized biopsies, which were distributed five groups: low-grade squamous intraepithelial lesions (LSIL), high-grade (HSIL), carcinoma (SCC), uterine adenocarcinoma (UCAC), and group cervicitis (as...
Molecular profile of breast cancer in Latin-American women was studied five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic molecular subtypes were described, the 60-month overall cumulative survival probabilities (OS) estimated. From 2011 to 2013, 1,300 eligible 18 years or older, with a diagnosis clinical stage II III, performance status ≦̸1 invited participate prospective cohort study. Face-to-face interviews...
Breast cancer is the number one cause of can- cer deaths among Hispanic women in United States, and Mexico, it recently became primary deaths. This malign- nancy represents a poorly understood un- derstudied disease women. The ELLA Binational Cancer Study was es- tablished 2006 as multi-center study to as- sess patterns breast tumor markers, clinical characteristics, their risk factors Mexican descent. We describe design implementation provide factor comparison between U.S. those Mexico...
KDM1A/LSD1 and ZNF217 are involved in a protein complex that participates transcriptional regulation. has been analysed numerous cancers its amplification associated with advanced stages of disease; however, similar role for not uncovered. In this study, we estimated the number gene copies tissue samples from patients diagnosed colorectal cancer (CRC), as well association clinicopathological features CRC. Paraffin-embedded tumour 50 CRC histopathological diagnosis were included. The genes...
Endosulfan (ENDO) is a widely used organochlorine (OC) pesticide and persistent organo-pollutant. Epidemiological studies have shown that high levels of OC exposure were related to colorectal cancer (CRC) incidence. The objectives the present study evaluate histological changes in colon, as well situ expression β-catenin P-selectin, serum select pro-inflammatory cytokines mice administered ENDO; there relationship between increased IL-6 P-selectin CRC patients aberrant signaling important...
B-cell activating factor (BAFF) is a major cytokine that regulates survival, maturation and differentiation through its binding with receptors: BAFF receptor (BAFF-R), transmembrane activator cyclophilin ligand interactor (TACI) antigen (BCMA). These receptors have been demonstrated to be involved in tertiary lymphoid structure formation; however, their role germinal centers (GCs) has remained elusive. The aim of the present study was determine expression profiles secondary tissues. Tonsils...
Background: The B-cell activating factor (BAFF) controls the maturation and survival of B cells. An imbalance in this cytokine has been associated with systemic autoimmunity SLE lupus nephritis (LN). However, few investigations have evaluated tissular expression BAFF LN. This study aimed to associate system at level proliferative LN classes. Methods: analysis included eighteen kidney tissues, sixteen (class III = 5, class IV 6, III/IV+V 4, V 1), two controls. was an immunochemistry assay. A...
Breast cancer mortality rates in Latin America (LA) are higher than those the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The American Cancer Research Network was established to address these challenges and promote collaborative clinical research. Molecular Profiling Study (MPBCS) aimed evaluate characteristics treatment outcomes LA participants with locally breast (LABC).
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an expressed in a wide variety of tissues including epithelial cells, leukocytes, and tumors that may establish both homotypic heterotypic interactions. The aim this work was to study the protein expression pattern CEACAM1 cervical cancer precursor lesions context human papillomavirus (HPV) infection. We used immunohistochemistry analyze formalin-fixed, paraffin-embedded from 15 healthy women, patients with low-grade...
Breast cancer (BC) is the leading cause of cancer-related deaths among women in Mexico.Two single-nucleotide polymorphisms (SNPs) thymidylate synthase (TS) gene, 28-base pair (bp) ©FUNPEC-RP www.funpecrp.com.
Chronic periodontitis (CP) is characterized by gingival inflammation and bone destruction. It has been reported that interferon-gamma (IFN-γ) levels are high in CP patients; however, the IFN-γ receptor (IFN-γR) not studied tissue from these patients. Objective: To evaluate IFN-γR expression biopsies chronic patients compared with healthy subjects (HS). Material Methods: Gingival tissues were obtained all study subjects, (n = 18) (HS) 12). A section of each subject was embedded paraffin...
Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. This syndrome inherited an autosomal dominant pattern early onset colorectal cancer (CRC) extracolonic tumors. The aim of this study was to identify MMR three Mexican patients with LS. Methods. Immunohistochemical analysis performed as a prescreening method absent protein expression. PCR, Denaturing High Performance Liquid Chromatography (dHPLC), Sanger...
Purposes Most molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of Latin American population. Searching for similarities differences in molecular pathways associated with these tumors evaluating its impact prognosis may help to select better therapeutic approaches. Patients Methods We collected clinical, pathological, transcriptomic data a multi-country cohort 1,071 stage II-III patients Molecular Profile Breast Cancer...
Background: Nonalcoholic fatty liver disease (NAFLD) is generated by the interaction between environmental and genetic factors, presence of metabolic alterations. Since Taq1B cholesteryl ester transfer protein (CETP) polymorphism associated with abnormal serum lipid values, it could be related to NAFLD. The aim this study was determine role CETP lipids, anthropometric variables, extent steatosis in Mexican-mestizo women gallstone (GD). Methods: Sixty-two were enrolled cross-sectional study....
Introduction: Interleukin-6 (IL-6) is a circulating proinflammatory cytokine that fulfills an important role in the survival and proliferation of cancer cells. Overexpression IL-6, possibly due to −174G>C −596G>A polymorphisms IL6 gene, has been shown be related breast (BC) more aggressive course disease. Aim: To determine influence gene on levels IL-6 BC patients from Jalisco, México. Methodology: Genotyping two was carried out 208 219 healthy controls through polymerase chain...
CMTM6 is a membrane protein that acts as regulator of PD-L1, maintaining its expression on the cell surface, and can prevent lysosome-mediated degradation. It unknown if present in plasma patients with cervical cancer, it has non-canonical subcellular localizations lines derived from cancer. Our objective was to determine whether found cancer localization lines. Patient separated into exosome-enriched, exosome-free, total fractions. The levels each fraction were determined using ELISA...
Breast cancer (BC) is the leading cause of death from tumors in women worldwide, influenced by various factors, including genetics. The T allele single nucleotide variant (SNV) rs3025039 at position +936 VEGFA gene has been reported to affect mRNA regulatory mechanisms, potentially altering expression and increasing BC risk. This study aimed investigate association between Mexican residing Jalisco, Mexico. included 231 with a confirmed diagnosis 201 healthy subjects as reference group (RG)....