A5031379378- Cellular Mechanics and Interactions
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Cell Image Analysis Techniques
- Neural Networks and Applications
- Advanced Fluorescence Microscopy Techniques
- Topological and Geometric Data Analysis
- Muscle activation and electromyography studies
- Breast Cancer Treatment Studies
- Neuroscience and Neuropharmacology Research
- Sports injuries and prevention
- Hemophilia Treatment and Research
- Advanced Vision and Imaging
- Developmental Biology and Gene Regulation
- Face recognition and analysis
- Myofascial pain diagnosis and treatment
- Health disparities and outcomes
- Visual perception and processing mechanisms
- Neurogenetic and Muscular Disorders Research
- Trypanosoma species research and implications
- Microtubule and mitosis dynamics
- Stroke Rehabilitation and Recovery
- Photoreceptor and optogenetics research
- Cellular transport and secretion
- Philosophical Thought and Analysis
Instituto de Neurociencia Biomédica
2014-2024
University of Chile
2015-2024
Center for Climate and Resilience Research
2023-2024
Center for Mathematical Modeling
2022
Weatherford College
2022
Vrije Universiteit Amsterdam
2021
Institute of Biomedical Science
2019
Neuroscience Institute
2018
Alberto Hurtado University
2017
Pius Hospital de Valls
2014
Abstract Different authors have modelled myofascial tissue connectivity over a distance using cadaveric models, but in vivo models are scarce. The aim of this study was to evaluate the relationship between pelvic motion and deep fascia displacement medial gastrocnemius (MG). Deep MG evaluated through automatic tracking with an ultrasound. Angular variation pelvis determined by 2D kinematic analysis. average maximum were 1.501 ± 0.78 mm 6.55 2.47 °, respectively. result simple linear...
Abstract The spreading of mesenchymal-like cell layers is critical for embryo morphogenesis and tissue repair, yet we know little this process in vivo . Here take advantage unique developmental features the non-conventional annual killifish to study principles underlying a simple cellular environment, devoid patterning signals major morphogenetic movements. Using experimentation physical modelling reveal that extra-embryonic epithelial enveloping layer, thought mainly provide protection...
Significance The expression of genes involved in hippocampal synaptic plasticity, learning, and memory requires that Ca 2+ signals generated spines, dendrites, or the soma by neuronal stimulation reach nucleus. Here, we report neurons induces release mediated RyR2 channels, which contributes to nuclear signal generation. Suppression RyR-mediated inhibited activity-induced phosphorylation transcriptional regulator CREB Npas4 transcription factor RyR2, play crucial roles processes. We propose...
Automated language analysis of speech has been shown to distinguish healthy control (HC) vs chronic schizophrenia (SZ) groups, yet the predictive power on first-episode psychosis patients (FEP) and generalization non-English speakers remain unclear. We performed a cross-sectional longitudinal (18 months) automated in 133 Spanish-speaking subjects from three groups: or HC (n = 49), FEP 40), SZ 44). Interviews were manually transcribed, included 30 features (4 verbal fluency; 20 productivity;...
Abstract Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed chronically with a high-fat diet (HFD). PA impairs insulin signaling hypothalamic neurons, by mechanism dependent on autophagy, process lysosomal-mediated degradation cytoplasmic material. In addition, previous work shows crosstalk between autophagy and primary cilium (hereafter cilium), an antenna-like structure cell surface that acts as platform for cell. Ciliopathies, human diseases characterized...
<h3>Background:</h3> Psychological stress of parents preterm infants is aggravated by prolonged hospitalisation. Early discharge programmes (EDPs) have been implemented to alleviate this situation. <h3>Objective:</h3> To evaluate parental psychological in an EDP for the first 3 months after neonatal intensive care unit (NICU) discharge. <h3>Design/methods:</h3> Prospective randomised trial comparing assigned (n = 72) or standard programme (SDP) (standard discharge) 68). At discharge, were...
Stroke is currently the world's second cause of disability. It can deficits such as postural control, and telerehabilitation could improve therapeutic dose well functional results. The aim this work to determine effectiveness usability a low-cost system in patients with stroke. We developed based on exergames smartphones, inertial sensors, cloud database. trained balance six participants (three men three women) early subacute stroke (seven weeks progress). In addition their conventional...
Molecular profile of breast cancer in Latin-American women was studied five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic molecular subtypes were described, the 60-month overall cumulative survival probabilities (OS) estimated. From 2011 to 2013, 1,300 eligible 18 years or older, with a diagnosis clinical stage II III, performance status ≦̸1 invited participate prospective cohort study. Face-to-face interviews...
Introduction Widespread pain may be related to psychosocial aspects in several musculoskeletal conditions, but the literature on carpal tunnel syndrome (CTS) is scarce.
Breast cancer mortality rates in Latin America (LA) are higher than those the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The American Cancer Research Network was established to address these challenges and promote collaborative clinical research. Molecular Profiling Study (MPBCS) aimed evaluate characteristics treatment outcomes LA participants with locally breast (LABC).
Abstract Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues generate complex internal organs and number of studies epithelia have outlined general view tissue internalisation. Here we used quantitative live imaging mutant analysis to determine whether similar mechanisms are responsible for in that apparently does not typical epithelial organisation – the zebrafish neural plate. We found although embryos begin neurulation without conventional epithelium,...
Abstract This study examined whether a knee flexor isometric contraction at 20% of maximal voluntary until exhaustion would alter the biceps femoris long head (BFlh) and semitendinosus (ST) active stiffness, assessed using ultrasound-based shear wave elastography. Twelve healthy individuals participated in 2 sessions separated by 7 days. Time to was similar both (day 1: 443.8 ± 192.5 s; day 2: 474.6 131.7 p = 0.323). At start fatigue task, ST showed greater stiffness than BFlh (p <...
Haemophilic arthropathy is the result of repetitive intraarticular bleeding and synovial inflammation. In people with haemophilic (PWHA), very little known about neural control individual muscles during movement. The aim present study was to assess if muscles, coordination between antagonistic muscle pairs joint kinematics gait are affected in PWHA. Thirteen subjects (CG) walked overground at their preferred slow velocity (1 m/s) fourteen PWHA m/s). Joint temporal parameters were assessed...
The fascia provides and transmits forces for connective tissues, thereby regulating human posture movement. One way to assess the myofascial interaction is a ultrasound recording. Ultrasound can follow fascial displacement either manually or automatically through two-dimensional (2D) method. possible method iterated Lucas-Kanade Pyramid (LKP) algorithm, which based on automatic pixel tracking during passive movements in 2D assessments. Until now, accumulated error over time has not been...
Effects of haemophilic arthropathy on neuromuscular control during gait are currently unknown.(a) To assess how affects the complexity gait; (b) investigate relationship between and joint impairment.Thirteen subjects (CG) walked overground at their preferred a slow velocity thirteen people with (PWHA) walking velocity. Surface electromyography (EMG) was collected from eleven leg muscles. Electromyography variance explained by muscle synergies (sets co-activated muscles that can be recruited...
Abstract This study examined whether professional footballers with previous biceps femoris long head (BFLH) injury in the last 3-years present a smaller proximal aponeurosis (Apo-BFLH) size compared to no injury. We Apo-BFLH and BFLH using magnetic resonance imaging tested knee flexor maximal isometric strength 80 thighs of 40 footballers. parameters were processed semi-automated procedure. Outcomes between (n=9) vs. without (n=71) No differences observed injured non-injured for (p>0.05)...
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat mood and anxiety disorders. Chronic treatment with this antidepressant drug thought favor functional recovery by promoting structural molecular changes in several forebrain areas. At the synaptic level, chronic fluoxetine induces an increased size density of dendritic spines ratio GluN2A over GluN2B N-methyl-D-aspartate (NMDA) receptor subunits. The "maturation"-promoting observed after should also induce remodeling...
Age-related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia in subjects with normal or mild loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as objective and sensitive tool estimate the decline older adults
Persistence diagrams (PD)s play a central role in topological data analysis, and are used an ever increasing variety of applications. The comparison PD requires computing distances among large sets PDs, with metrics which accurate, theoretically sound, fast to compute. Especially for denser multi-dimensional such lacking. While on the one hand, Wasserstein-type have high accuracy theoretical guarantees, they incur computational cost. On other between vectorizations as Statistics (PS)s lower...