A5066365811- Cellular Mechanics and Interactions
- Developmental Biology and Gene Regulation
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Structure and Function
- Hippo pathway signaling and YAP/TAZ
- Microtubule and mitosis dynamics
- Protease and Inhibitor Mechanisms
- Connective tissue disorders research
- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Muscle Physiology and Disorders
- Cell death mechanisms and regulation
- Erythrocyte Function and Pathophysiology
- Cell Adhesion Molecules Research
- Genetics and Physical Performance
- Phagocytosis and Immune Regulation
Centre for Genomic Regulation
2019-2024
Austral University of Chile
2018-2019
The nucleus makes the rules Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints dense tissues, physical activity, injury all impose changes cell shape. How can measure shape deformations ensure correct tissue development homeostasis remains largely unknown (see Perspective by Shen Niethammer). Working independently, Venturini et al. Lomakin now show that act as an intracellular ruler cellular variations. nuclear envelope...
Abstract Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis compromise tissue function. Despite the widespread occurrence fibrotic diseases scarring, effective therapies are lacking. A promising approach would be limit amount collagen released from hyperactive fibroblasts. We have designed membrane permeant peptide inhibitors that specifically target primary interface between TANGO1 cTAGE5, an interaction is required for export endoplasmic...
Abstract Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues generate complex internal organs and number of studies epithelia have outlined general view tissue internalisation. Here we used quantitative live imaging mutant analysis to determine whether similar mechanisms are responsible for in that apparently does not typical epithelial organisation – the zebrafish neural plate. We found although embryos begin neurulation without conventional epithelium,...
Abstract The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress space constraints within local environment remains largely unknown. Here we show that the nucleus, biggest cellular organelle, functions as a non-dissipative deformation gauge enables to continuously measure variations on time scale of seconds. Inner nuclear membrane unfolding together with relative...
Abstract Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues generate complex internal organs and number of studies epithelia have outlined general view tissue internalisation. Here we used quantitative live imaging mutant analysis to determine whether similar mechanisms are responsible for in that apparently does not typical epithelial organisation – the zebrafish neural plate. We found although embryos begin neurulation without conventional epithelium,...