A5064794040- Cellular Mechanics and Interactions
- Nuclear Structure and Function
- Microtubule and mitosis dynamics
- Calcium signaling and nucleotide metabolism
- Adenosine and Purinergic Signaling
- Vagus Nerve Stimulation Research
University of East Anglia
2024
Universitat Pompeu Fabra
2019-2020
The nucleus makes the rules Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints dense tissues, physical activity, injury all impose changes cell shape. How can measure shape deformations ensure correct tissue development homeostasis remains largely unknown (see Perspective by Shen Niethammer). Working independently, Venturini et al. Lomakin now show that act as an intracellular ruler cellular variations. nuclear envelope...
Abstract The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress space constraints within local environment remains largely unknown. Here we show that the nucleus, biggest cellular organelle, functions as a non-dissipative deformation gauge enables to continuously measure variations on time scale of seconds. Inner nuclear membrane unfolding together with relative...