A5009979542- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Systemic Sclerosis and Related Diseases
- Lipid Membrane Structure and Behavior
- Connective tissue disorders research
- Pomegranate: compositions and health benefits
- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- Biochemical and Structural Characterization
- Protease and Inhibitor Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Calcium signaling and nucleotide metabolism
- Axon Guidance and Neuronal Signaling
- Kruppel-like factors research
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Antimicrobial Peptides and Activities
Institute for Stem Cell Biology and Regenerative Medicine
2021-2024
Manipal Academy of Higher Education
2022-2023
Abstract Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis compromise tissue function. Despite the widespread occurrence fibrotic diseases scarring, effective therapies are lacking. A promising approach would be limit amount collagen released from hyperactive fibroblasts. We have designed membrane permeant peptide inhibitors that specifically target primary interface between TANGO1 cTAGE5, an interaction is required for export endoplasmic...
Preservation of a small population cancer stem cells (CSCs) within heterogeneous carcinoma serves as paradigm to understand how select in tissue maintain their undifferentiated status. In both embryogenesis and cancer, Snail has been correlated with stemness, but the molecular underpinning this phenomenon remains largely ill-defined. models cutaneous squamous cell (cSCC), we discovered non-epithelial-mesenchymal transition function for transcription factor maintaining stemness epidermal...
The continual emergence of SARS-CoV-2 variants threatens to compromise the effectiveness worldwide vaccination programs, and highlights need for complementary strategies a sustainable containment plan. An effective approach is mobilize body's own antimicrobial peptides (AMPs), combat infection propagation. We have found that human cathelicidin (LL37), an AMP at epithelial barriers as well in various bodily fluids, has capacity neutralise multiple strains SARS-CoV-2. Biophysical computational...
Fibrosis results from excessive extracellular matrix (ECM) deposition, causing tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, ECM production. However, it remains unclear if the same fibroblast performs all of processes that fall under umbrella term "activation". Due heterogeneity in connective tissues, subpopulations with specific functions may operate distinct regulatory controls. Using a...
ABSTRACT Fibrosis is the result of excessive deposition extracellular matrix (ECM) proteins leading to tissue hardening and loss organ function. A central player driving fibrosis activated fibroblast, which exhibits enhanced migration, proliferation, contraction, ECM production. However, this raises an interesting puzzle whether same fibroblast performs all processes that fall under umbrella term “activation”. Given heterogeneity fibroblasts in connective tissues, there are subpopulations...
Summary Intratumoral heterogeneity poses a major challenge in designing effective anti-cancer strategies. Accumulating evidence suggests that this arises from cancer stem cells (CSCs) also drives tumor aggressiveness and drug resistance. The stemness of CSCs are preserved by an ill-defined combination intrinsic external factors is particularly intriguing since they exist within sea similar at various degrees differentiation. In models cutaneous squamous cell carcinoma (cSCC), we discovered...
ABSTRACT Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes onset fibrosis we observed that this phenomenon recapitulated in Snail transgenic mouse model SSc. The vascular anomalies manifest as deformed vessels, endothelial cell dysfunction leakage. Our investigation into mechanism phenotype revealed Angiopoietin-like...
Abstract The continual emergence of new SARS-CoV-2 variants threatens the effectiveness worldwide vaccination programs and highlights need for complementary strategies a sustainable containment plan. A promising approach is to mobilize body⍰s own antimicrobial peptides (AMPs), combat infection propagation. We have found that human cathelicidin (LL37), an AMP at epithelial barriers as well in various bodily fluids, has capacity neutralise multiple strains SARS-CoV-2. Biophysical computational...