A5000538303- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Mast cells and histamine
- T-cell and B-cell Immunology
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Redox biology and oxidative stress
- Axon Guidance and Neuronal Signaling
- Skin and Cellular Biology Research
- Dermatologic Treatments and Research
- Hair Growth and Disorders
- Connective Tissue Growth Factor Research
Institute for Stem Cell Biology and Regenerative Medicine
2016-2024
National Centre for Biological Sciences
2018-2022
Fibrosis is a prevalent pathological condition arising from the chronic activation of fibroblasts. This results extensive intercellular crosstalk mediated by both soluble factors and direct cell-cell connections. Prominent among these are interactions fibroblasts with immune cells, in which fibroblast-mast cell connection, although acknowledged, relatively unexplored. We have used Tg mouse model skin fibrosis, based on expression transcription factor Snail epidermis, to probe mechanisms...
Preservation of a small population cancer stem cells (CSCs) within heterogeneous carcinoma serves as paradigm to understand how select in tissue maintain their undifferentiated status. In both embryogenesis and cancer, Snail has been correlated with stemness, but the molecular underpinning this phenomenon remains largely ill-defined. models cutaneous squamous cell (cSCC), we discovered non-epithelial-mesenchymal transition function for transcription factor maintaining stemness epidermal...
Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal organs, leading poor prognosis. Unraveling etiology of chronic, multifactorial such as systemic has been aided by various animal models recapitulate certain aspects human pathology. We found transcription factor SNAI1 overexpressed epidermis patients with sclerosis, transgenic mouse recapitulating this expression pattern sufficient induce many clinical features disease. Using model discovery...
Fibrosis results from excessive extracellular matrix (ECM) deposition, causing tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, ECM production. However, it remains unclear if the same fibroblast performs all of processes that fall under umbrella term "activation". Due heterogeneity in connective tissues, subpopulations with specific functions may operate distinct regulatory controls. Using a...
Abstract The delivery of plasmid DNA to the skin can target distinct subsets dermal dendritic cells confer a superior immune response. needle-free immunization technology offers reliable, safe and efficient means administer intradermal (ID) injections. We report here that ID injection vectors using an NF device (NF-ID) elicits cell-mediated response, at much lesser dosage, comparable in magnitude traditional intramuscular immunization. However, humoral response is significantly impaired,...
ABSTRACT Fibrosis is the result of excessive deposition extracellular matrix (ECM) proteins leading to tissue hardening and loss organ function. A central player driving fibrosis activated fibroblast, which exhibits enhanced migration, proliferation, contraction, ECM production. However, this raises an interesting puzzle whether same fibroblast performs all processes that fall under umbrella term “activation”. Given heterogeneity fibroblasts in connective tissues, there are subpopulations...
Summary Intratumoral heterogeneity poses a major challenge in designing effective anti-cancer strategies. Accumulating evidence suggests that this arises from cancer stem cells (CSCs) also drives tumor aggressiveness and drug resistance. The stemness of CSCs are preserved by an ill-defined combination intrinsic external factors is particularly intriguing since they exist within sea similar at various degrees differentiation. In models cutaneous squamous cell carcinoma (cSCC), we discovered...
The skin plays an important role in protecting the body from pathogens and chemicals external environment. Upon injury, a healing program is rapidly initiated involves extensive intercellular communication to restore tissue homeostasis. deregulation of this crosstalk can lead abnormal processes foundation many diseases. A relatively overlooked cell type that nevertheless critical roles homeostasis, wound repair, disease dendritic epidermal T cells (DETCs), which are also called γδT-cells....