A5026268115- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Minimally Invasive Surgical Techniques
- Reproductive System and Pregnancy
- Pelvic floor disorders treatments
- Reproductive Biology and Fertility
- Pelvic and Acetabular Injuries
- Ovarian cancer diagnosis and treatment
- Intestinal and Peritoneal Adhesions
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy-related medical research
- Hernia repair and management
- Colorectal Cancer Surgical Treatments
- Reproductive Health and Technologies
- Menstrual Health and Disorders
- Endometrial and Cervical Cancer Treatments
- Gestational Trophoblastic Disease Studies
- Growth Hormone and Insulin-like Growth Factors
- Gastric Cancer Management and Outcomes
- Appendicitis Diagnosis and Management
- Diet and metabolism studies
- Stress Responses and Cortisol
Nippon Medical School Hospital
2008-2024
Yamato Municipal Hospital
2022-2024
Chiba Hokusou Hospital
2024
The Japanese Society of Gastroenterological Surgery
2021-2024
Nippon Medical School
2014-2023
The University of Tokyo
2004
The Ohio State University
1993
Point mutations in the mitochondrial (mt) tRNA(Leu(UUR)) gene are responsible for myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), a subgroup of encephalomyopathic diseases. We previously showed that mt with an A3243G or T3271C mutation derived from patients MELAS deficient normal taurine-containing modification (taum5U; 5-taurinomethyluridine) at anticodon wobble position. To examine decoding disorder mutant tRNA due to deficiency independent pathogenic point...
In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and safety efficacy of surgery evaluated. accordance with social acceptance as less invasive type number has increased all surgical domains. The Japan Society for Endoscopic Surgery (JSES) played an important role development Japan. Notably, technical skills certification system surgeons established by JSES to train instructors on how teach...
Six years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, third revised published in 2017. 2017 Guidelines includes 10 additional clinical questions (CQ), brings total to 95 CQ (12 on infectious disease, 28 oncology benign tumors, 27 endocrinology infertility healthcare women). Currently a consensus has been reached therefore objective this report is present...
Abstract Problem In women of reproductive age, endometriosis may contribute to dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, adenomyosis, and endometrial ovarian cyst (EOC). Recent studies have shown that inflammation occurs in the pelvis patients this is exacerbated by immunosuppression, leading survival debris. However, detailed immunological mechanisms underlying aggravation immunosuppression remain unclear. Method Study We investigate alarmins (high‐mobility group box‐1,...
Abstract This article reports the results of 16th National Survey conducted by Japan Society for Endoscopic Surgery (JSES) 2020 and 2021. Laparoscopic cholecystectomy was first introduced to in 1990 has rapidly become popular because its minimally invasive nature. Since then, number objective organs indications laparoscopic surgery have gradually expanded. In 2021, 290 787 patients underwent endoscopic all surgical domains. Of these, 124 614, 110 757, 23 156, 21 771, 6543, 2614, 535, 465,...
Abstract In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedure has been standardized, and safety usefulness of surgery have evaluated. accordance with social acceptance as less‐invasive number procedures increasing all surgical domains. The Japan Society for Endoscopic Surgery (JSES) played an important role development Japan. For example, JSES established technical skills certification system surgeons to train...
Assisted reproductive technology procedures infrequently cause pelvic abscesses, but the risk is higher in patients with endometriosis. If antibiotic treatment of a abscess unsuccessful, surgery required-even during pregnancy. We report two endometriosis who suffered from abscesses formed after egg collection and embryo transfer. Patient 1 underwent laparoscopic resection left adnexa right ovarian cystectomy diagnosis implantation failure. Surgical findings showed severe adhesions pelvis due...
The aim of this study was to assess the cut-off age risk factors for postoperative recurrence ovarian endometriomas and evaluate end-points follow-up after laparoscopic excision endometriomas.We retrospectively reviewed 167 patients who underwent at our hospital between 2000 2009, followed up until 2010. Following surgery, chose receive gonadotrophin-releasing hormone agonist, oral contraceptive pills (OCP), dienogest, or no medication regular ultrasonographic examinations. Potential...
In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and safety usefulness of surgery evaluated. With acceptance as less invasive than open number continues to increase all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has had an important role development Japan. For example, JSES established technical skills certification system physicians train instructors teach safe...
Genome-wide association studies (GWASs) have discovered numerous single nucleotide polymorphisms (SNPs) associated with human complex disorders. However, functional characterization of the disease-associated SNPs remains a formidable challenge. Here we explored regulatory mechanism SNP on chromosome 9p21 endometriosis by leveraging "allele-specific" genomic approaches. By re-sequencing 1.29 Mb region and scrutinizing DNase-seq data from ENCODE project, prioritized rs17761446 as candidate...
Study objective: The aim of this study is to evaluate the efficacy hormonal therapies for inhibiting an increase in uterine volume patients with adenomyosis.Design: This was retrospective cohort study.Setting: conducted at Nippon Medical School Musashikosugi Hospital. Patients: A total 28 women diagnosed adenomyosis using magnetic resonance imaging.Methods: After providing informed consent, were treated gonadotropin-releasing hormone agonist (GnRHa group), a low-dose estrogen and progestin...
This study elucidated the degree of adenomyosis recurrence following gonadotropin-releasing hormone agonist (GnRHa) discontinuation and dienogest efficiency for recurrent adenomyosis. retrospective cohort included 30 patients, divided into a group patients whose progress was observed without providing additional therapy GnRHa administration six months (Group G) administered D). Menorrhagia, dysmenorrhea, chronic pelvic pain, abdominal fullness, uterine volume were recorded prior to...
Abstract Aim To investigate the accuracy and clinical value of an adhesion scoring system using transvaginal ultrasonography for endometriotic adhesion. Methods In this prospective observational study, we included 131 patients with endometriosis who underwent surgery. Before surgery, mapping were performed to determine presence or absence adhesions at 10 sites pelvis. Mapping was determined by comparing findings surgical findings. severity pelvic adhesions, developed score (0–10). With...
Abstract Aim: To examine the efficacy of local methotrexate (MTX) administration following linear salpingostomy for tubal pregnancy in prevention persistent ectopic (PEP). Methods: Patients who underwent a laparoscopic between January 1996 and December 2006 were enrolled study. assigned to prophylaxis group administered MTX (50 mg) into wall vicinity lesion immediately ( n = 41). treated without control 40). Serum human chorionic gonadotrophin levels followed both groups postoperatively once...
Osteopontin (OPN), a secreted glycoprotein, has multiple physiological functions. This study investigated the regulation and roles of OPN in mouse ovary during periovulatory stages. Immature female mice were treated with pregnant mare serum gonadotropin (PMSG) human chorionic (hCG) to simulate follicle maturation ovulation. In situ hybridization real-time RT-PCR performed assess expression Opn ovary. Granulosa cells (GCs) from PMSG-primed immature cultured or without hCG presence absence...
Abstract In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and safety efficacy of surgery evaluated. accordance with social acceptance as less invasive type number has increased all surgical domains. The Japan Society for Endoscopic Surgery (JSES) played an important role development Japan. Notably, technical skills certification system surgeons established by JSES to train instructors on...
Hyperreactio luteinalis (HL) is characterized by bilaterally enlarged ovaries containing multiple self-limited theca lutein cysts and usually associated with increased production of human chorionic gonadotropin in the presence trophoblastic disease or pregnancies. About 30 cases HL have been reported patients normal singleton pregnancies, most these required surgical intervention during their first pregnancy because ovarian torsion to rule out malignancy. However, accurate diagnosis means...