A5048367144- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Reproductive Health and Technologies
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Gynecological conditions and treatments
- Pregnancy and Medication Impact
- Reproductive Physiology in Livestock
- Pregnancy-related medical research
- Prenatal Screening and Diagnostics
- Preterm Birth and Chorioamnionitis
- Systemic Lupus Erythematosus Research
- Ovarian function and disorders
- Gestational Trophoblastic Disease Studies
- Congenital Anomalies and Fetal Surgery
- Neonatal Respiratory Health Research
- Ectopic Pregnancy Diagnosis and Management
- Adenosine and Purinergic Signaling
- Maternal and fetal healthcare
- Urological Disorders and Treatments
- Animal Genetics and Reproduction
- Autopsy Techniques and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
Nippon Medical School
2016-2025
Nippon Medical School Hospital
2014-2024
Tokyo Rinkai Hospital
2011
Aretaeio Hospital
2007
Stanford University
2004-2005
University Health Network
2003
University of Toronto
2003
Japanese Red Cross Katsushika Maternity Hospital
2001-2003
The physiological role of an orphan G protein-coupled receptor, LGR5, was investigated by targeted deletion this seven-transmembrane protein containing a large N-terminal extracellular domain with leucine-rich repeats. LGR5 null mice exhibited 100% neonatal lethality characterized gastrointestinal tract dilation air and absence milk in the stomach. Gross histological examination revealed fusion tongue to floor oral cavity mutant newborns immunostaining expression epithelium mandible...
Since 1986, the Japan Society of Obstetrics and Gynecology assisted reproductive technology (ART) registry system has collected data on national ART use outcomes trends in Japan. Herein, we describe characteristics cycles registered during 2020 compare results with those from 2019.
Glycoprotein hormones play important roles in thyroid and gonadal function vertebrates. The glycoprotein hormone alpha-subunit forms heterodimers with different beta-subunits to activate TSH or gonadotropin (LH FSH) receptors. Recent genomic analyses allowed the identification of another alpha-subunit, GPA2, beta-subunit, GPB5, human, capable forming Based on comparative searches, we isolated fly orthologs for human GPA2 each consisting 10 cysteine residues likely involved cystine-knot...
Abstract Purpose The Japan Society of Obstetrics and Gynecology (JSOG) has collected cycle‐based assisted reproductive technology (ART) data in an online registry since 2007. Herein, we present the characteristics treatment outcomes ART cycles registered during 2017. Methods We cycle‐specific information for all implemented at participating facilities performed descriptive analysis. Results In total, 448,210 56,617 neonates (1 16.7 born Japan) were reported 2017, increased from 2016; number...
In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loop (Gln-423-Lys-433) around FAD cofactor underwent large dislocations during conversion, blocking approach NAD+ substrate well changing electrostatic environment FAD. Here we identify unique cluster...
Since 2007, the Japan Society of Obstetrics and Gynecology (JSOG) has collected cycle-based data for assisted reproductive technology (ART) in an online registry. Here, we present characteristics treatment outcomes ART cycles registered during 2018.The Japanese registry consists cycle-specific information all implemented at 621 participating facilities. We conducted descriptive analyses such 2018.In total, 454 893 56 979 neonates were reported 2018: both increased from 2017. The mean...
Abstract Purpose The Japan Society of Obstetrics and Gynecology (JSOG) registry gathers comprehensive data from registered assisted reproductive technology (ART) facilities in Japan. Herein, we report 2021 ART cycle characteristics outcomes. Methods Descriptive statistics were used to summarize analyze data. Results In 2021, 625 participated the registry; 27 did not conduct cycles 598 treatment cycles. total, 498 140 registered, there 69 797 neonates (increases 10.7% 15.5%, respectively,...
Abstract Twelve years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, 5th Revised Edition published in 2023. 2023 Guidelines includes 5 additional clinical questions (CQs), brings total to 103 CQ (12 on infectious disease, 30 oncology benign tumors, 29 endocrinology infertility 32 healthcare women). Currently, a consensus has been reached Guidelines, therefore,...
Abstract Aim Maternal vitamin K (VK) deficiency can lead to fetal complications such as cerebral hemorrhage and bone malformations. In this study, we aimed analyze changes in prothrombin time (PT) protein induced by VK absence or antagonist II (PIVKA‐II) patients with severe hyperemesis gravidarum suspected deficiency. Methods We compared 151 treated intravenous nutrition 46 undergoing cervical suturing benign ovarian tumor surgery before mid‐pregnancy. Results the group, coagulation...
Heparin and aspirin (HA) therapy is used for antiphospholipid syndrome (APS)-associated recurrent pregnancy loss (RPL). Low-dose (LDA) recommended thrombophilic predispositions, such as antibodies that do not completely meet the Sydney classification criteria APS, protein S deficiency, factor XII deficiency increased platelet aggregation. However, no established strategy exists cases where LDA ineffective. Therefore, this study aimed to identify characteristics of RPL unresponsive determine...
Abstract Nine years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, 4th Revised Edition published in 2020. 2020 Guidelines includes 4 additional clinical questions (CQ), brings total to 99 CQ (12 on infectious disease, 29 oncology benign tumors, endocrinology infertility healthcare women). Currently, a consensus has been reached Guidelines, therefore, objective...
The Japan Society of Obstetrics and Gynecology records online annual cycle-based information for assisted reproductive technology (ART). This report presents the characteristics treatment outcomes ART cycles registered during 2019.
The present study investigated serum adenosine deaminase (ADA) activity and the patterns of two ADA isoenzymes, ADA1 ADA2, to evaluate possible role cell-mediated immunity as causes changes in pre-eclampsia. We measured activities total ADA, ADA2 pre-eclampsia (n = 22) normal pregnancy 22). Peripheral blood monocyte counts neopterin levels, reflecting activation monocyte-macrophage cell system, were also measured. In pre-eclampsia, significantly increased compared with (p < 0.05), which...
Osteopontin (OPN), a secreted glycoprotein, has multiple physiological functions. This study investigated the regulation and roles of OPN in mouse ovary during periovulatory stages. Immature female mice were treated with pregnant mare serum gonadotropin (PMSG) human chorionic (hCG) to simulate follicle maturation ovulation. In situ hybridization real-time RT-PCR performed assess expression Opn ovary. Granulosa cells (GCs) from PMSG-primed immature cultured or without hCG presence absence...
The aim of this study was to investigate the possible mechanism regulation plasma adenosine concentration [ADO] in normal pregnancy. We measured activities circulating enzymes that are involved production and metabolism adenosine, nonpregnant (n = 14) pregnant women third trimester. In women, activity 5'-nucleotidase were significantly elevated deaminase reduced. Enzymatic both appear be changed a way would favor increased concentrations.
This review examines associations of nutrients and dietary preferences with recurrent pregnancy loss (RPL), miscarriage, infertility. Research articles, reviews, meta-analyses RPL infertility that focused on nutrition, meals, lifestyle were reviewed, are discussed in relation to recent research findings. Studies related given the highest priority, followed by those dealing miscarriage Multivitamin supplements-even when lacking folic acid or vitamin A-reduced total fetal loss. High-dose...
Abstract Purpose This descriptive analysis evaluated the 2022 assisted reproductive technology (ART) data collected by Japan Society of Obstetrics and Gynecology registry. Methods Results In (cutoff date 30 November 2023), 634 635 registered ART facilities participated; 602 implemented treatment, with 543 630 cycles 77 206 neonates (9.1% 10.6% increases from previous year). For fresh cycles, freeze‐all in vitro fertilization intracytoplasmic sperm injection increased, resulting 2183 2822...
Abstract Purpose A hysteroscopic metroplasty was performed for women with recurrent pregnancy loss owing to a uterine septum, following which some became infertile. The aim of this study elucidate the risk factors secondary infertility 1 year after septum. Methods retrospective, single‐center, cohort included history at least two miscarriages that had been attributed septum who underwent metroplasty. patients’ background data were compared between patients conceived and those remained...