A5012079433- Ovarian function and disorders
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Reproductive Biology and Fertility
- Stress Responses and Cortisol
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Hormonal and reproductive studies
- Prenatal Screening and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Reproductive Health and Technologies
- Adipose Tissue and Metabolism
- Plant Reproductive Biology
- Endometrial and Cervical Cancer Treatments
- Neuropeptides and Animal Physiology
- Phytoestrogen effects and research
- Circadian rhythm and melatonin
- Growth Hormone and Insulin-like Growth Factors
- Biochemical Analysis and Sensing Techniques
- Estrogen and related hormone effects
Tokushima University
2016-2025
Sumitomo Seika Chemicals (Japan)
2022
Tokushima Red Cross Hospital
2022
Tokushima University Hospital
2016
University of California, Berkeley
2013
Kagawa National Children's Hospital
2010
Kitasato University
1994
Hyogo Prefectural Institute of Technology
1993
Gonadotropin-inhibitory hormone (GnIH), a newly discovered hypothalamic RFamide peptide, inhibits reproductive activity by decreasing gonadotropin synthesis and release in birds. The gene of the mammalian RFamide-related peptides (RFRP) is orthologous to GnIH gene. This Rfrp gives rise two biologically active RFRP-1 (NPSF) RFRP-3 (NPVF), i.c.v. injections suppress LH secretion several species. In this study, we show whether affects at pituitary level and/or via GnRH hypothalamus mammals. To...
Abstract Aim The Japan Society of Obstetrics and Gynecology implemented a registry report system for the clinical practice assisted reproductive technology in 1986. aggregated results from 1992 to 2014 are reported herein. Methods Results total number registered treatments was 393 745 cycles, which 66 550 were pregnancy cycles 46 008 with live birth. Compared 2008, when cycle‐based newly introduced, there 2.07‐fold increase 2.25‐fold As average age patients who receive has become markedly...
Since 1986, the Japan Society of Obstetrics and Gynecology assisted reproductive technology (ART) registry system has collected data on national ART use outcomes trends in Japan. Herein, we describe characteristics cycles registered during 2020 compare results with those from 2019.
Recent studies have suggested that intrauterine undernutrition is closely associated with the pathogenesis of diseases after birth. Perinatal known to disturb development reproductive function and delay onset puberty in some species. Using a rat model, we determined effects prenatal on hypothalamic kisspeptin system evaluated whether alteration contributes delayed induced by undernutrition. We also developmental changes serum leptin levels because was putative positive regulator system....
The Japan Society of Obstetrics and Gynecology conducted a nationwide clinical study to evaluate the pregnancy outcomes preimplantation genetic testing for aneuploidy or chromosomal structural rearrangement (PGT-A/SR).
11-oxygenated C19 steroids (11oxC19s) are newly specified human androgens. Although median serum levels of 11oxC19 were reported to be higher in patients with polycystic ovary syndrome (PCOS) than unaffected women, inter-individual variations androgen among PCOS have poorly been investigated. Here, we quantified four 11oxC19s, i.e., 11-ketotestosterone (11KT), 11β-hydroxytestosterone (11OHT), 11β-hydroxyandrostenedione (11OHΔ4A), and 11-ketoandrostenedione (11KΔ4A), blood samples 28 31...
Abstract Purpose The Japan Society of Obstetrics and Gynecology (JSOG) registry gathers comprehensive data from registered assisted reproductive technology (ART) facilities in Japan. Herein, we report 2021 ART cycle characteristics outcomes. Methods Descriptive statistics were used to summarize analyze data. Results In 2021, 625 participated the registry; 27 did not conduct cycles 598 treatment cycles. total, 498 140 registered, there 69 797 neonates (increases 10.7% 15.5%, respectively,...
To establish cut-off values for anti-Müllerian hormone (AMH) and antral follicle count (AFC) in the diagnostic criteria polycystic ovary syndrome (PCOS) applicable to Japan Society of Obstetrics Gynecology (JSOG) 2024 Rotterdam/International Evidence-Based Guideline assessment management PCOS (IEBG) 2023 based on a nationwide survey, respectively, taking into account age, assays, structure criteria.
Kisspeptin, which is the product of kiss1 gene and its receptor kiss1r, have emerged as essential gatekeepers reproduction. The present study used gonadally intact female rats to evaluate fasting-induced suppression KiSS-1 system anteroventral periventricular nucleus (AVPV) arcuate (ARC) under normal physiological conditions. Starting on day estrous, one group was subjected 72 h food deprivation, while other able continue feeding ad libitum. length estrous cycle significantly longer in...
Hypersecretion of luteinizing hormone (LH) is a common endocrinological finding polycystic ovary syndrome (PCOS). This derangement might have close relationship with hypothalamic kisspeptin expression that thought to be key regulator gonadotropin-releasing (GnRH). We evaluated the between hypothalamic-pituitary-gonadal axis (HPG axis) and using rat model PCOS induced by letrozole. Letrozole pellets (0.4 mg/day) control were placed subcutaneously onto backs 3-week-old female Wistar rats. Body...
Abstract The Women's Health Care Committee was established in 2010 to improve the health of women. In current academic year, this committee seven subcommittees aimed at understanding diseases related various age groups women, including adolescence, sexual maturity, and menopause, promoting research quality life. Additionally, socially significant has focused on infections, particularly resistant bacteria. activities each subcommittee are described. This report is based Japanese version...
<title>Abstract</title> <bold>Objective</bold> The aim of this report is to describe techniques and provide basic available scientific data on the success testicular size procedures. <bold>Methods</bold> In prospective longitudinal study, 186 normal fetuses from 23 weeks gestation were followed up by ultrasonography. We assessed testis descent in scrotum measured major (mm) minor axes testes fetuses, as well height newborn infants. Testicular sizes compared among five periods (23-26 weeks,...
Introduction: What if porcine placental extract (PPE) could combat post-menopausal weight gain and lipid imbalances without the side effects of traditional hormone treatments? The menopause marks a critical shift in women’s health, with declining estrogen levels driving increased risks obesity, metabolic dysfunction, cardiovascular disease. While replacement therapy remains common intervention, concerns over its long-term safety have intensified search for safer alternatives. Objectives:...
Abstract The mammalian gonadotropin‐inhibitory hormone (GnIH) ortholog RFamide‐related peptide (RFRP) is considered to act on gonadotropin‐releasing (GnRH) neurons and the pituitary inhibit gonadotropin release synthesis. To understand functional significance of this neuropeptide, we investigated physiological changes in RFRP at mRNA levels, as well level its cognate receptor, G protein‐coupled receptor 147 ( GPR147 ), rat hypothalamus during development. We also effects gonadal steroids...
Polycystic ovary syndrome (PCOS) is an ovulatory disorder that affects 6-10% of women reproductive age. Serum AMH level may be additional factor, or surrogate PCOM, in the diagnostic criteria PCOS. We evaluated correlations between serum and various endocrine metabolic features PCOS using latest fully automated assay. was compared 114 patient (PCOS group) 95 normal menstrual cycle (Control group). Correlations factors were analysed group. The significantly higher group (8.35±8.19 ng/mL) than...
The Japan Society of Obstetrics and Gynecology records online annual cycle-based information for assisted reproductive technology (ART). This report presents the characteristics treatment outcomes ART cycles registered during 2019.