A5045891920- Algal biology and biofuel production
- Sperm and Testicular Function
- Marine Sponges and Natural Products
- Regulation of Appetite and Obesity
- Advanced Drug Delivery Systems
- Microbial Natural Products and Biosynthesis
- Earthquake and Disaster Impact Studies
- Lipid Membrane Structure and Behavior
- Radiation Therapy and Dosimetry
- Hypothalamic control of reproductive hormones
- Transboundary Water Resource Management
- Biochemical Analysis and Sensing Techniques
- Diatoms and Algae Research
- Neuropeptides and Animal Physiology
- Hydrology and Watershed Management Studies
- Drug Transport and Resistance Mechanisms
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Flood Risk Assessment and Management
- Aquaculture Nutrition and Growth
- Neurobiology and Insect Physiology Research
- Advancements in Transdermal Drug Delivery
- Antioxidant Activity and Oxidative Stress
- Natural product bioactivities and synthesis
National Institutes for Quantum Science and Technology
2005-2025
Osaka Ohtani University
2010-2023
Kogakuin University
2010-2022
Aichi Gakuin University
2021-2022
Kokushikan University
2022
Renaissance Services (United States)
2022
Kochi University of Technology
2001-2021
Kyoritsu Women's University
2013-2021
Hyogo University of Health Sciences
2015-2018
University of Health Sciences
2015-2018
Gonadotropin-inhibitory hormone (GnIH), a newly discovered hypothalamic RFamide peptide, inhibits reproductive activity by decreasing gonadotropin synthesis and release in birds. The gene of the mammalian RFamide-related peptides (RFRP) is orthologous to GnIH gene. This Rfrp gives rise two biologically active RFRP-1 (NPSF) RFRP-3 (NPVF), i.c.v. injections suppress LH secretion several species. In this study, we show whether affects at pituitary level and/or via GnRH hypothalamus mammals. To...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSupercritical carbon dioxide extraction of oils from Antarctic krillKatsumi Yamaguchi, Masahiro Murakami, Hiroshi Nakano, Shoji Konosu, Tsunehiko Kokura, Yamamoto, Masahiko Kosaka, and Kazuhiko HataCite this: J. Agric. Food Chem. 1986, 34, 5, 904–907Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September...
Recent studies have suggested that intrauterine undernutrition is closely associated with the pathogenesis of diseases after birth. Perinatal known to disturb development reproductive function and delay onset puberty in some species. Using a rat model, we determined effects prenatal on hypothalamic kisspeptin system evaluated whether alteration contributes delayed induced by undernutrition. We also developmental changes serum leptin levels because was putative positive regulator system....
The effects of bile salts, sodium taurocholate and glycocholate, on drug absorption from the rat small intestine were investigated using in situ perfusion technique. There are three likely mechanisms by which salts can effect ; first, loss thermodynamic acitivity a due to formation micellar complex second, local concentration build-up such as an accumulation absorptive surface third, direct permeability characteristics intestinal mucosa. sulfanilamide was not affected, but sulfaguanidine...
Focusing on the "size" impact of particles, objective this study was to analyze morphological and qualitative changes over time in development inflammation collagen deposition lung tissue after intratracheal instillation two sizes nickel oxide rats, comparison with results crystalline silica titanium dioxide. The fine-sized sample (nNiOm: median diameter agglomerated particles 0.8 μm) prepared from crude (median primary particle 27 nm) by liquid-phase separation. Another samples...
The objective of this study was to examine what kinds cytokines are related lung disorder by well-dispersed nanoparticles. mass median diameter nickel oxide in distilled water 26 nm. Rats intratracheally received 0.2 mg suspended water, and were sacrificed from three days six months. concentrations 21 including inflammation, fibrosis allergy-related ones measured the lung. Infiltration alveolar macrophages observed persistently oxide-exposed group. Expression macrophage inflammatory...
Since nanoparticles easily agglomerate to form larger particles, it is important maintain the size of their agglomerates at nano-level evaluate harmful effect nanoparticles. We prevented agglomeration nickel oxide by ultrasound diffusion and filtration, established an acute exposure model using animals, examined inflammation chemokine expression. The mass median diameter nanoparticle suspended in distilled water for intratracheal instillation was 26 nm (8.41 weighted average surface primary...
We used fullerenes, whose dispersion at the nano-level was stabilized by grinding in nitrogen gas an agitation mill, to conduct intratracheal instillation study and inhalation exposure study. Fullerenes were individually dispersed distilled water including 0.1% Tween 80, diameter of fullerenes 33 nm. These suspensions directly injected as a solution The reference material nickel oxide water. Wistar male rats intratracheally received dose 0.1 mg, 0.2 or 1 mg sacrificed after 3 days, week,...
Anabaenopeptins I (1) and J (2), two new ureido bond-containing cyclic peptides, were isolated from the cultured cyanobacterium Aphanizomenon flos-aquae (NIES-81) as potent carboxypeptidase-A (CPA) inhibitors. The gross structures of 1 2 established by spectroscopic analysis, including 2D NMR techniques. absolute configurations determined spectral chemical methods. inhibited CPA with IC50 values 5.2 7.6 ng/mL, respectively.
Serine protease inhibitory glycopeptides, aeruginosins 205 A (1) and -B (2), were isolated from the cyanobacterium Oscillatoria agardhii (NIES-205). The gross structures of these glycopeptides elucidated by mass 2D NMR spectral data. planar structure 2 was same as that 1 but differed in stereochemistries 3-hydroxyleucine (Hleu) phenyllactic acid 2-O-sulfate (Plas). These are potent inhibitors trypsin thrombin.
Botryococcus braunii strain Austin and Berkeley cultured under the same conditions contained 27.4g 34.0g of lipids per 100g dry alga, respectively. The in former were 25.5% hydrocarbons, 58.8% other nonpolar lipids, 15.7% polar those latter 71.6%, 9.2%, 19.2%, Distinct differences also observed components especially latter, between strains. fatty acid composition lipid fraction was unique, oleic being 81% total acids.
The human DOC-2/DAB2 interactive protein (hDAB2IP) gene is a novel member of the Ras GTPase-activating family and has been demonstrated to be tumour-suppressor inactivated by methylation in several cancers. In this study, we analysed expression status hDAB2IP gastrointestinal tumours. promoter region was divided into two regions (m2a m2b) based on our previous report, determined bisulphite DNA sequencing gastric cancer cell lines. semiquantified real-time RT-PCR, results indicated that m2b...
The intestinal absorption of 125I-labelled palmitoyl insulin was examined following administration into in-situ closed large loops rats. When mono- and dipalmitoyl insulins (Palins-1 Palins-2, respectively) were administered in polyoxyethylene hydrogenated castor oil (HCO 60) micellar system loops, a marked increase plasma radioactivity corresponding disappearance residual the lumen observed rank order: Palins-2 greater than Palins-1 native insulin. In addition, derivatives more stable...