A5046213781- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Management of metastatic bone disease
- Multiple and Secondary Primary Cancers
- Intraperitoneal and Appendiceal Malignancies
- Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Brain Metastases and Treatment
- Frailty in Older Adults
- Lymphatic System and Diseases
- Body Composition Measurement Techniques
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Enhanced Recovery After Surgery
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
National Hospital Organization Hokkaido Medical Center
2014-2023
Sapporo National Hospital
2014-2023
Hokkaido University Hospital
2006-2019
Hokkaido University
2000-2016
Obihiro Kosei General Hospital
2016
Gynecologic Oncology Group
2011-2012
Kyowa Kirin (Japan)
2005
High-grade endometrioid and serous endometrial cancers (ECs) are an aggressive subtype of ECs without effective therapies. The reciprocal communication between tumor cells their surrounding microenvironment drives progression. Long noncoding RNAs (lncRNAs) key mediators tumorigenesis metastasis. However, little is known about the role lncRNAs in EC progression remodeling. We performed array-based lncRNA analysis a parental HEC-50 cell population derivatives with highly invasive,...
The objective of this study is to describe a technique for preserving the autonomic nerve systematically, including hypogastric nerves, pelvic splanchnic and plexus its vesical branches, based on anatomic considerations nerves innervating urinary bladder, in radical hysterectomies assess postsurgical bladder function. A nerve-sparing hysterectomy was carried out 27 consecutive patients with uterine cervical cancer treated between 2000 2002. FIGO stages disease consisted 10 stage Ib1, 6 Ib2,...
Objective:The aim of this study was to clarify the clinical significance isolated tumor cells (ITCs) or micrometastasis (MM) in regional lymph nodes patients with International Federation Gynecology and Obstetrics (FIGO) stage I II endometrial cancer.Methods: In study, a series 63 FIGO were included, who had at least one following risk factors for recurrence: G3 endometrioid/serous/clear cell adenocarcinomas, deep myometrial invasion, cervical involvement, lympho-vascular space positive...
Six years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, third revised published in 2017. 2017 Guidelines includes 10 additional clinical questions (CQ), brings total to 95 CQ (12 on infectious disease, 28 oncology benign tumors, 27 endocrinology infertility healthcare women). Currently a consensus has been reached therefore objective this report is present...
Objective: Concurrent chemoradiotherapy (CCRT) is the primary treatment for locally advanced cervical cancer.We studied prognostic factors patients treated with CCRT.Methods: We retrospectively reviewed records of 85 consecutive cancer who were CCRT between 2002 and 2011, external beam radiation therapy, intracavitary brachytherapy, platinum-based chemotherapy.Survival data analyzed Kaplan-Meier methods Cox proportional hazard models.Results: Of patients, 69 (81%) had International...
Epithelial-mesenchymal transition (EMT) is a key process contributing to cervical cancer (CC) metastasis, and microRNAs (miRNAs) modulate the expression of genes implicated in EMT. However, accurate role miR-361 CC-associated EMT mechanisms underlying its function CC remains largely unknown. The functional roles cells were explored by series cell assays. Luciferase reporter assays used demonstrate potential interaction between miR-361, HSP90, long non-coding RNA (lncRNA) NEAT1. We detected...
Although para-aortic lymphadenectomy (PALX) has not been accepted as a standard treatment for patients with endometrial cancer, it is possible that systematic including PALX therapeutic significance intermediate-/high-risk cancer. On the other hand, consensus regarding safety of reached. The aim this study was to compare incidence rates postoperative complications after pelvic (PLX) or without in uterine corpus cancer.A retrospective chart review carried out all cancer treated at 2 tertiary...
We wanted to investigate the clinical usefulness of determining pretreatment levels multiple serum tumor markers in predicting lymph node status and prognosis for patients with cervical carcinoma.The preoperative squamous cell carcinoma antigen (SCC), cancer antigens CA125 CA19-9 were assayed simultaneously 103 stages IB IIB SCC undergoing radical hysterectomy. The cut-off values SCC, CA125, this study 1.5 ng/ml, 35 U/ml, 37 respectively. relation between marker histopathologic prognostic...
BACKGROUND To the authors' knowledge there are few available data regarding influence of lymphovascular space invasion, which has been examined separately as two components (lymphatic vessel invasion [LVI] and blood [BVI]), in metastasis cervical carcinoma. METHODS LVI BVI, include capillary were reviewed retrospectively based on histopathologic slides 239 women with carcinoma who treated radical hysterectomy. The correlation between lymph node and/or ovarian metastases LVI, other factors...
To compare the clinical efficacy focused on post-treatment morbidity between adjuvant chemotherapy (CT) and pelvic radiotherapy (RT) after radical hysterectomy for patients with cervical cancer.A total of 125 squamous cell carcinoma who underwent lymphadenectomy at Hokkaido University Hospital 1991 2002 were enrolled in study retrospective analysis. Seventy recurrent risk factors, including deep stromal invasion, lymph vascular space parametrial node metastasis (LNM), bulky tumor (>or=4 cm),...
To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo dissection hysterectomy.This is a retrospective analysis nation-wide cohort study surgically-treated stage IB-IIB cervical cancer (n=5,620). Multivariate models were used to identify independent metastasis/recurrence.There 120 (2.1%) cases surgery with parametrial involvement (adjusted odds ratio [aOR]=1.65), deep stromal...
According to the International Federation of Gynecology and Obstetrics staging, some surgeons perform lymphadenectomy in all patients with early stage endometrial cancer enable accurate staging. However, there are risks such as lower limb lymphedema. The aim this study was investigate whether preoperative assessment is useful select whom can be safely omitted.We evaluated risk lymph node metastasis (LNM) using LNM score (histological grade, tumor volume measured magnetic resonance imaging...
Abstract Nine years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, 4th Revised Edition published in 2020. 2020 Guidelines includes 4 additional clinical questions (CQ), brings total to 99 CQ (12 on infectious disease, 29 oncology benign tumors, endocrinology infertility healthcare women). Currently, a consensus has been reached Guidelines, therefore, objective...