A5013947994- Pharmacy and Medical Practices
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Asthma and respiratory diseases
- Cervical Cancer and HPV Research
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy-related medical research
- Lymphatic System and Diseases
- Ovarian cancer diagnosis and treatment
- Bone health and osteoporosis research
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Pharmaceutical Practices and Patient Outcomes
- Natural product bioactivities and synthesis
- Allergic Rhinitis and Sensitization
- Clinical practice guidelines implementation
- Redox biology and oxidative stress
- Head and Neck Surgical Oncology
- Birth, Development, and Health
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Economic and Financial Impacts of Cancer
Keio University
2016-2025
RELX Group (Netherlands)
2024
Nagasaki University
2024
Research Experiences for Undergraduates
2021-2024
Hokkaido University
2012-2023
Hokkaido University Hospital
2014-2020
Teikyo Heisei University
2020
Jikei University School of Medicine
2018
Tokyo Medical University
2010-2018
Eli Lilly (Japan)
2012-2017
Nonalcoholic fatty liver disease (NAFLD) includes simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. The gut-derived endotoxin plays an essential role in the pathophysiological development progression of NAFLD. By using rat models choline-deficient/L-amino acid-defined (CDAA)-diet-induced NAFLD, we examined whether MIYAIRI 588–a butyrate-producing probiotic – prevents changes from steatosis to hepatocarcinogenesis. In vivo experiments...
High-grade endometrioid and serous endometrial cancers (ECs) are an aggressive subtype of ECs without effective therapies. The reciprocal communication between tumor cells their surrounding microenvironment drives progression. Long noncoding RNAs (lncRNAs) key mediators tumorigenesis metastasis. However, little is known about the role lncRNAs in EC progression remodeling. We performed array-based lncRNA analysis a parental HEC-50 cell population derivatives with highly invasive,...
Epithelial-to-mesenchymal transition (EMT) and aerobic glycolysis are fundamental processes implicated in cancer metastasis. Although increasing evidence demonstrates an association between EMT induction enhanced human cancer, the mechanisms linking these two conditions endometrial (EC) cells remain poorly defined.We characterized role molecular mechanism of glycolytic enzyme hexokinase 2 (HK2) mediating investigated how long noncoding RNA DLEU2 contributes to stimulation via upregulation...
Epithelial-mesenchymal transition (EMT) is a key process contributing to cervical cancer (CC) metastasis, and microRNAs (miRNAs) modulate the expression of genes implicated in EMT. However, accurate role miR-361 CC-associated EMT mechanisms underlying its function CC remains largely unknown. The functional roles cells were explored by series cell assays. Luciferase reporter assays used demonstrate potential interaction between miR-361, HSP90, long non-coding RNA (lncRNA) NEAT1. We detected...
Undernutrition is a common risk after surgery or during periods when oral dietary intake challenging. Enteral nutrients, frequently utilized in nutritional management, are drugs associated with multiple contraindications involving pathology and allergy, they require careful attention dispensing. However, the occurrence of nutrition-related incidents community pharmacies remains unknown. This study aimed to identify issues regarding safety pharmacotherapy patients requiring enteral nutrition...
Few studies on the prognosticators of patients with recurrent endometrial cancer after relapse have been reported in literature. The aim this study was to determine who underwent primary complete cytoreductive surgery and adjuvant chemotherapy.Thirty-five were included retrospective analysis. prognostic significance several clinicopathological factors including histologic type, risk for recurrence, time surgery, number sites, site relapse, treatment modality, resection tumors evaluated....
FSH regulates follicular growth in a stage-development fashion. Although preantral follicle stage is gonadotropin responsive, not required for growth. With the antrum, follicles continue growing under influence of and become dependent. thyroid hormone important normal female reproductive function, its role interaction with regulation ovarian yet to be defined. In present study, we have examined action T(3) follicles, especially their transition from early antral stage, using an established...
Cervical cancer incidence and mortality is increasing in Japanese women under age 50. Screening uptake low proactive recommendations for human papillomavirus vaccination have been suspended. Other cervical prevention initiatives are urgently needed. We assessed whether self-sampling might be an acceptable alternative to physician-led screening, particularly with limited experience of tampon use. also sought identify any practical, logistical, or safety issues already attending before...
Increased glycolysis in tumor cells is frequently associated with drug resistance. Overexpression of glucose transporter-1 (GLUT1) promotes the Warburg effect and mediates chemoresistance various cancers. Aberrant GLUT1 expression considered as an essential early step development endometrial cancer (EC). However, its role EC upstream mechanisms underlying overexpression, remain undefined. Here, we demonstrated that was highly expressed tissues cell lines high poor prognosis patients. Both...
Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not other normal tissues. To date, there has been no comprehensive study of the expression clinical significance CTA genes associated with endometrial cancer (EC) development. Additionally, relevance, biological role, molecular mechanisms gene TTK protein kinase (TTK) EC yet to be fully understood.Using bioinformatics methods, we comprehensively investigated genomic, transcriptomic, epigenetic changes...
The aim of this study was to investigate the prognostic factors and treatment outcome patients with adenocarcinoma uterine cervix who underwent radical hysterectomy systematic lymphadenectomy.A total 130 stage IB IIB cervical treated lymphadenectomy from 1982 2005 were retrospectively analyzed. Clinicopathological data including age, stage, tumor size, number positive node sites, lymphovascular space invasion, parametrial deep stromal invasion (>2/3 thickness), corpus vaginal infiltration,...
Abstract Purpose The prevalence of migraine headache is higher in women. Low barometric pressure a factor triggering, but sex-related differences have not been identified. purpose this study was to examine triggered by low pressure. Methods Study subjects aged 20–49 years were randomly selected from research company’s (Macromill, Inc.) web panel. Those with chronic or tension-type invited complete web-based self-administered questionnaire. Logistic regression analysis performed the objective...
Background Single-dose praziquantel (PZQ) for treating urogenital schistosomiasis has been reported as inadequate achieving significant resolution of female genital (FGS)-associated cervicovaginal lesions. This randomised controlled trial aimed to assess the efficacy and safety a repeated PZQ-dosing regimen. Methods The was conducted among women aged 15 34 with FGS-associated cervical lesions living in Schistosoma haematobium -endemic area northern Madagascar. A total 116 were randomly...
Abstract Background and Objectives The aim of this study was to analyze the stage migration survival endometrial cancer by revised FIGO 2008 staging system compared with 1988 system. Methods A total 355 patients cancer, who underwent complete surgical staging, were enrolled. We stages those Results resulted in an increase I decrease II IIIa patients. 5‐year overall (OS) rates for IA IB disease 98.2% 91.9%, respectively ( P = 0.004). Five‐year OS rate new (82.6%) significantly worse than that...
Interstitial lung disease (ILD) is important drug related toxicity because it commonly forced to discontinue the treatment.To characterize prevalence and patterns of pemetrexed induced ILD, an independent ILD advisory board composed external experts performed reassessment in two post marketing surveillance (PMS) studies for malignant pleural mesothelioma (MPM) non-small cell cancer (NSCLC).ILD incidences were originally 1.6% 2.6% 903 MPM 683 NSCLC patients safety analyses, respectively....