A5011419121- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Urinary Bladder and Prostate Research
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Wheat and Barley Genetics and Pathology
- Radiomics and Machine Learning in Medical Imaging
- Animal Genetics and Reproduction
- Renal cell carcinoma treatment
- Neuroscience and Neuropharmacology Research
- Cancer Mechanisms and Therapy
- Phosphodiesterase function and regulation
- Cancer Immunotherapy and Biomarkers
- Yeasts and Rust Fungi Studies
- MicroRNA in disease regulation
- Plant Disease Resistance and Genetics
- Meat and Animal Product Quality
- Multiple Myeloma Research and Treatments
- Molecular Sensors and Ion Detection
- Intensive Care Unit Cognitive Disorders
Guangzhou Sport University
2025
First Affiliated Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
Beijing Chao-Yang Hospital
2025
Capital Medical University
2024-2025
Mindray (China)
2025
University of Chinese Academy of Sciences
2023-2024
Center for Excellence in Molecular Plant Sciences
2023-2024
Chinese Academy of Sciences
2023-2024
Shandong University of Traditional Chinese Medicine
2022-2024
In the pig production industry, artificial insemination (AI) plays an important role in enlarging beneficial impact of elite boars. Understanding genetic architecture and detecting markers associated with semen traits can help improving selection for such accelerate progress. this study, we utilized a weighted single-step genome-wide association study (wssGWAS) procedure to detect regions further candidate genes Duroc boar population. Overall, full pedigree consists 5284 pigs (12...
Immune checkpoint inhibitors (ICIs) have been increasingly used in patients with various cancers and shown efficient therapeutic outcomes. However, fewer than 40% of cases across multiple cancer types show a response to ICIs. Therefore, developing more combinational approaches ICIs revealing the underlying mechanisms are important goals for achieving rapid clinical transformation application.The effects on antitumor immunity activity albendazole (ABZ) synergistic ABZ CD73 blockade were...
To extract sinapine from rapeseed meal and investigate its antihypertensive function mechanism. Blood pressure was measured before after administration to evaluate sinapine's immediate function. Twokidney, oneclip (2K1C) hypertensive rats were given for four weeks, with weekly blood monitoring. The renin angiotensin aldosterone system (RAAS), including the levels of renin, I (Ang I), II II), (ALD), angiotensin-converting enzyme (ACE) other molecules related pressure, such as NO, prostacyclin...
Objective This study aimed to develop and validate a multimodal deep learning model that utilizes preoperative grayscale contrast-enhanced ultrasound (CEUS) video data for noninvasive WHO/ISUP nuclear grading of renal cell carcinoma (RCC). Methods In this dual-center retrospective study, CEUS videos from 100 patients with RCC collected between June 2012 2021 were analyzed. A total 6,293 images categorized into low-grade (G1-G2) high-grade (G3-G4) groups. novel model, the Multimodal...
Meat quality is an important trait for pig-breeding programs aiming to meet consumers' demands. Geneticists must improve meat based on their understanding of the underlying genetic mechanisms. Previous studies showed that most meat-quality indicators were low-to-moderate heritability traits; therefore, improving using conventional techniques remains a challenge. Here, we performed genome-wide association study traits GeneSeek Porcine SNP50K BeadChip in 582 crossbred Duroc × (Landrace...
Apoptosis plays a crucial role in the occurrence of cancer and other diseases. Real-time monitoring cell apoptosis process has great significance for viability drug screening. Herein, novel fluorescent probe was constructed based on fluorescence resonance energy transfer mechanism, which track sensitivity polarity changes, as well detect drug-induced dual-color mode. Importantly, change cellular microenvironmental makes it possible to dynamically visualize apoptosis. More significantly,...
Objective To develop and validate a radiomics nomogram that could incorporate clinicopathological characteristics ultrasound (US)-based signature to non-invasively predict Ki-67 expression level in patients with breast cancer (BC) preoperatively. Methods A total of 328 lesions from 324 BC who were pathologically confirmed our hospital June 2019 October 2020 included, they divided into high group low group. Routine US shear wave elastography (SWE) performed for each lesion, the ipsilateral...
Subcellular organelles play an indispensable role in various biological process. Therefore, it is very important to develop fluorescent probe identify different and their dynamics specific processes. Herein, a new has been prepared, which can be used visualize cell death via targeting mitochondria lipid droplets (LDs) dual-emission channels. The appeared the form of ring-open emit strong yellow fluorescence living cells, while carried out intramolecular spiral cyclization reaction target LDs...
The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to play an oncogenic role in various types of cancers. However, the function MTHFD2 urothelial carcinomas bladder (UCB) and its association with tumor immune infiltration remains unknown. We aim examine suitability be a novel biomarker cancer whether is linked infiltration.RNA sequencing data clinical information (bladder samples: normal samples =...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, and CD4+ T lymphocytes can inhibit hepatocarcinogenesis mediate tumor regression. However, few studies have focused on prognostic power Tconv-related lncRNAs in HCC patients.We obtained data from TCGA GEO databases identified CD4+Tconv-related HCC. The risk score was constructed using lasso regression model validated two validation cohorts. RS also assessed different clinical subgroups, a nomogram...
Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not other normal tissues. To date, there has been no comprehensive study of the expression clinical significance CTA genes associated with endometrial cancer (EC) development. Additionally, relevance, biological role, molecular mechanisms gene TTK protein kinase (TTK) EC yet to be fully understood.Using bioinformatics methods, we comprehensively investigated genomic, transcriptomic, epigenetic changes...
Although an increasing number of patients benefit from immunotherapy and targeted therapies, melanoma remains incurable with incidence. Drug repositioning repurposing is alternative strategy to discover develop novel anticancer drugs or combined therapeutic regimens. In this study, we demonstrated that albendazole (ABZ), Food Administration (FDA)-approved broad-spectrum antiparasitic agent, significantly inhibits the proliferation cells in vitro vivo. RNA sequencing flow cytometry analysis...
BackgroundThe pathology of keloid and especially the roles bacteria on it were not well understood.MethodsIn this study, multi-omics analyses including microbiome, metaproteomics, metabolomic, single-cell transcriptome cell-derived xenograft (CDX) mice model used to explore disease.FindingsWe found that types are significantly different between healthy skin. The 16S rRNA sequencing metaproteomics showed more catalase (CAT) negative bacteria, Clostridium Roseburia existed in compared with...
Abstract Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow transplantation several hypomethylating agents. However, many elderly patients cannot benefit from develop drug resistance to agents, making it urgent explore novel therapy. RSL3 can effectively induce ferroptosis in various tumors combination of agents is promising treat tumors. its effect MDS was unknown. In this study, we found that...
Purpose: Intestinal ischemia/reperfusion (I/R) injury is an unresolved clinical challenge due to its high prevalence, difficulty in diagnosis, and lack of clinically effective therapeutic agents. Ferroptosis a novel form cell-regulated death that has been shown play role various I/R models be immune-related. Further unraveling the molecular mechanisms associated with ferroptosis immunity intestinal may lead discovery potentially drugs. Methods: We obtained differentially expressed mRNAs...
In recent years, black testa peanut (Arachis hypogaea L.) has been favored because of its nutritional value and health function. To explore the genetic basis color, high-throughput sequencing technology was used to sequence transcriptome 'ZH9ʹ pink 'ZH8.ʹ Over 18 million high-quality reads were assembled into 49,404–52,578 genes for these two cultivars using a combined assembly strategy. Totally, 4,122 differentially expressed (DEGs) identified between ZH8 ZH9, among which 1317 (32%)...