A5101841414- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Acupuncture Treatment Research Studies
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Medical Research and Treatments
- Neurological Disorders and Treatments
- Evolution and Genetic Dynamics
- Nicotinic Acetylcholine Receptors Study
- Aquatic Ecosystems and Phytoplankton Dynamics
- Genetic diversity and population structure
- RNA regulation and disease
- Aquaculture disease management and microbiota
- Microbial infections and disease research
- Myxozoan Parasites in Aquatic Species
- Ginseng Biological Effects and Applications
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
Jining Medical University
2024-2025
Chinese People's Liberation Army
2020-2025
Chinese PLA General Hospital
2020-2025
Tarim University
2009-2024
Cloud Computing Center
2019-2024
Yunnan Open University
2024
Guangzhou Medical University
2014-2023
Second Military Medical University
2018-2023
National Natural Science Foundation of China
2023
Creative Commons
2023
Intrahepatic cholangiocarcinoma (ICC) ranks as the second most malignant type of primary liver cancer with a high degree incidence and very poor prognosis. Fat mass obesity-associated protein (FTO) functions an eraser RNA m6A modification, but its roles in ICC tumorigenesis development remain unknown. We showed here that level FTO was downregulated clinical samples cell lines expression inversely correlated CA19-9 micro-vessel density (MVD). A Kaplan-Meier survival analysis low predicted...
Abstract Background As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 mutant melanomas. However, acquired drug resistance invariably develops after its initial treatment. Methods Immunohistochemical staining was performed to detect expression iNOS and hTERT, p-p65, Epcam, CD44, PCNA mice melanoma xenografts. The proliferation migration cells were detected by MTT, tumorsphere culture, cell cycle, apoptosis, AO/EB assay colony...
Patients discharged from the intensive care unit (ICU) can experience post-intensive syndrome (PICS), which is comprised of cognitive, physical and psychological impairments. The objective this study was to identify prevalence risk factors associated with all three domains PICS at first third month after ICU discharge. A prospective descriptive-analytic conducted in two ICUs a Chinese university hospital. We used Healthy Aging Brain Care Monitor Self-Report version, scale 1 57, 57 indicating...
Although it has been widely accepted that protein arginine methyltransferase 1 (PRMT1) is a cancer-promoting gene in various cancers, the mechanism of PRMT1 hepatocellular carcinoma (HCC) requires more exploration. This study aimed to investigate role HCC growth and metastasis.We compared expression clinicopathological characteristics using paired adjacent noncancerous liver tissues from 210 patients immunohistochemistry analyses. Cell proliferation, colony formation migration were...
Gastric cancer incidence demonstrates a strong etiologic association with smoking. Nicotine, the major component in tobacco, is survival agonist that inhibits apoptosis induced by certain chemotherapeutic agents, but precise mechanisms involved remain largely unknown. Recently studies have indicated α5-nicotinic acetylcholine receptor (α5-nAChR) highly associated lung risk and nicotine dependence. Nevertheless, no information has been available about whether also affects proliferation of...
Polarity defects are frequently involved in liver diseases, such as chronic hepatitis and hepatocellular carcinoma (HCC). It was reported that vacuolar protein sorting 33B (Vps33b) plays critical roles the maintenance of hepatocyte polarity; however, functional mechanisms Vps33b HCC occurrence progression remain unknown. First all, we showed is down‐regulated human mouse cancer samples, low expression levels correlate with poor prognosis many patients. Liver‐specific deficiency induces...
Parkinson's disease (PD) features the degeneration and death of dopamine neurons in substantia nigra pars compacta formation Lewy bodies that contain α-synuclein. Among numerous PD etiologies, glutamate excitotoxicity is a research hot spot, transporters play key roles this theory. It has been shown expression transporter regulated by microRNAs. In study, we found levels function type 1 (GLT-1) were significantly reduced miR-543-3p was upregulated during development PD. Furthermore, our...
Abstract The α5-nicotinic acetylcholine receptor (α5-nAChR) is closely associated with nicotine-related lung cancer, offering a novel perspective for investigating the molecular pathogenesis of this disease. However, mechanism by which α5-nAChR functions in carcinogenesis remains to be elucidated. Lymphocyte antigen 6 (Ly6) proteins, like snake three-finger alpha toxins such as α-bungarotoxin, can modulate nAChR signaling. Ly6E, member Ly6 family, biomarker poor prognosis smoking-induced and...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, and CD4+ T lymphocytes can inhibit hepatocarcinogenesis mediate tumor regression. However, few studies have focused on prognostic power Tconv-related lncRNAs in HCC patients.We obtained data from TCGA GEO databases identified CD4+Tconv-related HCC. The risk score was constructed using lasso regression model validated two validation cohorts. RS also assessed different clinical subgroups, a nomogram...
High mobility group box1 (HMGB1) promotes inflammatory injury, and accumulating evidence suggests that it plays a key role in brain ischemia reperfusion (I/R), as well the development of diabetes mellitus (DM). The purpose this study was to investigate whether HMGB1 I/R DM mouse model. Diabetes induced by high-calorie diet streptozotocin treatment, cerebral middle artery occlusion. We examined levels following injury non-DM mice evaluated influence altered on severity injury. Serum factors...
Approximately 50% of cases with recurrent spontaneous abortion (RSA) have unexplained etiology. Aberrant expression transmembrane and ubiquitin-like domain containing 1 (TMUB1) is closely related to a series diseases, including RSA. However, the function underlying mechanism TMUB1 in occurrence RSA has not been described.
Multidrug resistance (MDR) is a major clinical obstacle in the successful treatment of patients with metastatic nasopharyngeal carcinoma (NPC). Results from previous studies suggest that microRNAs (miRNA) may be involved promoting MDR multiple cancer types. However, role miR‑125b modulating NPC elusive. In present study, expression cisplatin (DDP) ‑resistant CNE2 cells (CNE2/DDP) was compared parental counterparts, using reverse transcription‑quantitative polymerase chain reaction. A >3‑fold...
BACKGROUND Late diagnosis and metastasis are leading causes of the high mortality colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have been reported to play a critical role in development progression CRC. This study aimed explore clinical significance 2 novel lncRNAs - RP11-296E3.2 LEF1-AS1 including their expression pattern, as well diagnostic prognostic values, for metastatic CRC patients. MATERIAL AND METHODS was examined tissues (91 cases) plasma (60 from patients by real-time...
Glutamate excitotoxicity is caused by dysfunctional glutamate transporters and plays an important role in the pathogenesis of Parkinson's disease (PD); however, mechanisms that underlie regulation PD are still not fully elucidated. MicroRNAs(miRNA), which abundant astrocytes neurons, have been reported to play key roles regulating translation glutamate-transporter mRNA. In this study, we hypothesized miR-30a-5p contributes ubiquitin-mediated degradation transporter 1 (GLT-1). We demonstrated...
Background/Aims: Total saponin extracted from Tribulus terrestris (TSETT) has been reported to protect against atherosclerosis. We here investigate the cellular and molecular mechanisms of TSETT underlying protection Methods: Cell proliferation was measured with Methyl thiazolyl tetrazolium (MTT); Intracellular H2O2 DCFH-DA, a fluorescent dye; free Ca2+ confocal laser scanning microscopy; Genes expression gene array real-time quantitative polymerase chain reaction (RT-PCR); Phosphorylation...
Thelohanellus Kudo, 1933 is a species rich genus of Myxosporea, sharing many morphological similarities with Myxobolus but the former possesses single polar capsule, and latter has two. Based on molecular phylogenetic analyses, this distinguishing feature not monophyletic, members are intermixed species, calling into question validity Thelohanellus. The occurrence two capsules in small proportion spores as observed study suggests that these have capacity to express Myxobolus-like trait,...
Myxozoans are a group of cnidarian parasites, the present taxonomy which favors more comprehensive characterization strategy combining spore morphology, biological traits (host/organ specificity, tissue tropism), and DNA data over classical morphology-based taxonomy. However, systematist might again run into taxonomic dilemma if than two following exceptional cases were encountered at same time: extensive intraspecific polymorphism, interspecific morphological similarity, identical blurred...
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Here, we identified that increased miR-23a expression in HCC tissues was associated with worse survival. More importantly, found STAT5A a target miR-23a, whose levels significantly decreased tumor tissues. Stable Huh7 cells suppressed glucose metabolism and growth. Finally, this study showed negatively regulated STAT5A, which further activated AKT signaling to enable rapid for accelerated growth HCC. Taken...
Predation has been a major driver of the evolution prey species, which consequently develop antipredator adaptations. However, little is known about genetic basis underpinning adaptation to intensive predation. Here, we describe high-quality chromosome-level genome assembly (approx. 145 Mb, scaffold N50 11.45 Mb) Daphnia mitsukuri , primary forage for many fish species. Transcriptional profiling D. exposed kairomone revealed that this cladoceran responds predation risk through regulating...