A5071162542- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Endometriosis Research and Treatment
- Retinal and Optic Conditions
- Medicinal Plant Pharmacodynamics Research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Retinal Imaging and Analysis
- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- Heat shock proteins research
- Retinal Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
Eastern Hepatobiliary Surgery Hospital
2016-2025
Second Military Medical University
2016-2025
Nanjing Medical University
2024
Qingdao Municipal Center for Disease Control and Prevention
2024
Yangzhou University
2008-2024
Northern Jiangsu People's Hospital
2012-2024
Hainan General Hospital
2019-2023
Hainan Medical University
2023
Beijing Friendship Hospital
2014-2020
Capital Medical University
2014-2020
Abstract Immune infiltration of colorectal cancer (CRC) is closely associated with clinical outcome. However, previous work has not accounted for the diversity functionally distinct cell types that make up immune response. In this study, based on a deconvolution algorithm (known as CIBERSORT) and annotated expression profiles, we comprehensively analyzed tumor‐infiltrating cells present in CRC first time. The fraction 22 subpopulations was evaluated to determine associations between each...
Inflammation-based indexes have been used to predict survival and recurrence in cancer patients. Systemic immune-inflammation index (SII) was reported be associated with prognosis some malignant tumors. In the present study, we aimed explore association between SII of patients gastric cancer.We retrospectively analyzed data from 444 who underwent gastrectomy at First Affiliated Hospital Sun Yat-sen University January 1994 December 2005. Preoperative calculated. The Chi square test or...
Alternative splicing (AS), as a potent and pervasive mechanism of transcriptional regulatory, expands the genome's coding capacity involves in initiation progression cancer. Systematic analysis alternative colorectal cancer (CRC) is lacking greatly needed.RNA-Seq data corresponding clinical information CRC cohort were downloaded from TCGA portal. Then, java application, known SpliceSeq, was used to evaluate RNA patterns calculate Percent Spliced In (PSI) value. Differently expressed AS...
The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and analyze its association with the prognosis GC patients. Immunohistochemical staining, Western blotting, quantitative reverse-transcriptase polymerase chain reaction were performed MLKL tissue 117 Clinicopathological characteristics survival data retrospectively analyzed discover clinical importance expression. chi-square test used relationship between clinicopathological...
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Extracellular vesicles (EV) are critical mediators intercellular communication within tumor microenvironment, and cancer-cell-secreted EVs often facilitate cancer progression. Here we show that in HBV-associated HCC, tumor-cell-derived contain a TGFβ-inducible long noncoding RNA, termed HDAC2-AS2. enriched with HDAC2-AS2 progression by suppressing cytotoxicity intra-tumor CD8+ T cells. Mechanistically, activated...
Hypoxia can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT) invasion of cancer cells. However, their mechanisms remain unclear. The objective this study was to evaluate role Gli-1, an effector Hedgehog pathway, in hypoxia-induced EMT breast Human MDA-MB-231 cells were transfected with or Gli-1-specific small interfering RNA (siRNA) cultured under a normoxic hypoxic condition. relative levels HIF-1α, E-cadherin, vimentin characterized by quantitative RT-PCR...
Although it has been widely accepted that protein arginine methyltransferase 1 (PRMT1) is a cancer-promoting gene in various cancers, the mechanism of PRMT1 hepatocellular carcinoma (HCC) requires more exploration. This study aimed to investigate role HCC growth and metastasis.We compared expression clinicopathological characteristics using paired adjacent noncancerous liver tissues from 210 patients immunohistochemistry analyses. Cell proliferation, colony formation migration were...
Aim: Multidrug resistance (MDR) is closely correlated to an unfavorable prognosis in various human cancers. However, the clinical significance of expression MDR-related proteins p-glycoprotein (PGP), glutathione-s-transferases (GST-π), topoisomerase-II (Topo-II) and lung protein (LRP) primary gastric cardiac adenocarcinoma (PGCA) remains unclear. In this present study, total four kinds mentioned above were detected by using immunohistochemistry, their chemoresistance also investigated....
Portal vein tumor thrombus (PVTT) is a type of intrahepatic metastasis arising from hepatocellular carcinoma (HCC) and highly correlated with poor prognosis. Hypoxia common in solider tumors, including HCC, where it alters the behavior HCC cells. We asked whether how hypoxia contributes to PVTT formation. demonstrated that increased intratumoral strongly associated formation HCC. also showed 14-3-3ζ induced by cells correlates clinical samples. In addition, up-regulates HIF-1α expression...
IQGAP1 is a scaffolding protein that can regulate several distinct signaling pathways. The accumulating evidence has demonstrated plays an important role in tumorigenesis and tumor progression. However, the function of esophageal squamous cell carcinoma (ESCC) not been thoroughly investigated. In present study, we showed was overexpressed ESCC tissues, its overexpression correlated with invasion depth ESCC. Importantly, by using RNA interference (RNAi) technology successfully silenced gene...
Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting. We aimed to investigate modify the impact BMI on clinicopathological survival western Chinese BC patients.8,394 female from Western China Clinical Cooperation Group (WCCCG) between 2005 2015 were identified. Multivariable logistic regression Cox proportion hazard regressions used examine difference clinicopathologic characteristics categories.For premenopausal,...
Abstract Purpose Accumulating evidence indicated that triple‐negative breast cancer (TNBC) can stimulate stronger immune responses than other subtypes of cancer. We hypothesized integrating immune‐related genomic signatures with clinicopathologic factors may yield a predictive accuracy exceeding the currently available system. Methods Ten reflect specific immunogenic or microenvironmental features TNBC were identified and re‐analyzed using bioinformatic methods. Then, clinically annotated (n...
Abstract The filamentous fungus Neurospora crassa is a long-studied eukaryotic microbial system amenable to heterologous expression of native and foreign proteins. However, relatively few highly tunable promoters have been developed for this species. In study, we compare the tcu-1 nit-6 controlled GFP reporter gene in N. crassa. Although copper-regulated has previously characterized, first investigation exploring nitrogen-controlled genes We determined that fragments corresponding 1.5-kb...
The present study aimed to compare the imaging performance of two ultra-wide-field fluorescein angiography systems, namely OptosOptomap 200Tx (Optos 200Tx) and Heidelberg Spectralis (Spectralis). A total 18 patients (36 eyes) underwent using systems at Department Ophthalmology, Beijing Friendship Hospital (Beijing, China) between January June 2017. images were obtained as a single shot centered on macula. area within each four visualized quadrants calculated compared. averages individual...
Abstract Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified. This study aims investigate hepatoprotective effects potential phytochemicals. The immortalized human hepatocyte cell line L02 was treated with 200 μM emodin for 48 h, this as injury model. cells were both different concentrations...
Uterine corpus endometrial carcinoma (UCEC) belongs to a group of epithelial malignant tumors. Icaritin is the main active compound Epimedii Folium. has been utilized induce UCEC cells death. We wished identify potential targets for icaritin in treatment UCEC, as well provide groundwork future studies into its pharmacologic mechanism action. Network pharmacology was employed conduct investigations on icaritin. Target proteins were chosen from components treatment. A protein-protein...
In the present investigation, we evaluated effects of microRNA-365 (miR-365) on non-small-cell lung cancer (NSCLC) cell metastasis and invasion in patients with bone cancer.Blood samples from NSCLC healthy controls A549 adenocarcinoma line were included this study. Quantitative real-time PCR microarray performed blood samples. The MTT assay, luciferase reporter Transwell ELISA, western blot to evaluate expression associated factors.Expression miR-365 was reduced NSCLC. Downregulation...
Background Microvascular invasion (MVI) is a significant risk factor affecting survival outcomes of patients after R0 liver resection (LR) for hepatocellular carcinoma (HCC). However, whether the existing staging systems can distinguish prognosis with MVI and prognostic value in different subtypes remains to be clarified. Methods A dual-center retrospective data set 1,198 HCC who underwent LR was included study between 2014 2016. Baseline characteristics information were collected....
The objective of this study was to identify proteins that are differentially expressed in the cystic wall tissues ovarian endometriotic cysts, simple and normal tissues. Specimens cyst tissue, tissue (six specimens per group) were collected from patients who received gynecologic surgery, respectively. Differentially related cysts screened by use isobaric tags for relative absolute quantitation (iTRAQ) combined with functional annotation bioinformatics analyses. All validated using...
China has the world's most significant public health and economic burden of chronic respiratory disease. However, association between preserved ratio impaired spirometry (PRISm) mortality risk is unknown.