A5101451851- Congenital heart defects research
- Immune Cell Function and Interaction
- Congenital Heart Disease Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Renal and Vascular Pathologies
- RNA Interference and Gene Delivery
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Folate and B Vitamins Research
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Research and Splicing
Jinhua Academy of Agricultural Sciences
2025
Children's Hospital of Fudan University
2014-2024
Huazhong Agricultural University
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Aviation General Hospital
2024
China Medical University
2024
Children’s Hospital of Fudan University Xiamen Branch
2024
Second Hospital of Anhui Medical University
2021-2023
Anhui Medical University
2021-2023
Transforming growth factor β1 (TGF-β), enriched in the tumor microenvironment and broadly immunosuppressive, inhibits natural killer (NK) cell function by yet-unknown mechanisms. Here we show that TGF-β-treated human NK cells exhibit reduced cytolysis abrogated perforin polarization to immune synapse. This result was accompanied loss of surface expression activating Ig-like receptor 2DS4 NKp44, despite intact cytoplasmic stores these receptors. Instead, TGF-β depleted DNAX protein 12 kDa...
Although recent evidence supports a tumor-suppressive role for the GTPase RhoB, little is known about its regulation by signal transduction pathways.Here we demonstrate that Ras downregulates RhoB expression phosphatidylinositol 3-kinase (PI3K)-and Akt-but not Mek-dependent mechanism.Furthermore, genetic and pharmacological blockade of PI3K/Akt results in upregulation expression.We also provide importance downregulation oncogenesis demonstrating antagonizes Ras/PI3K/Akt malignancy.Ectopic...
Abstract BACKGROUND: Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may alter the processing, transcription, and expression of miRNAs and, thus, contribute to cancer development. The authors hypothesized that common pre‐miRNAs are associated individually (more likely) collectively with risk squamous cell carcinoma head neck (SCCHN). METHODS: genotyped 4 pre‐miRNAs: Homo sapiens miRNA 146a ( hsa‐mir‐146a ) (reference SNP 2910164 [rs2910164]; guanine cytosine [G→C]), hsa‐mir‐149...
As an important tumor suppressor, programmed cell death 4 (PDCD4) influences transcription and translation of multiple genes, modulates different signal transduction pathways. However, the upstream regulation this gene is largely unknown. In study, we found that microRNA-182 (miRNA-182, miR-182) was upregulated, whereas PDCD4 downregulated in ovarian cancer tissues lines. Blocking or increase miR-182 lines led to opposite alteration endogenous protein level. Using fluorescent reporter assay,...
Abstract Polymorphonuclear neutrophils (PMN) are phagocytic cells constitutively programmed for apoptotic cell death. Exposure to GM-CSF delays apoptosis as measured by annexin-V staining and morphological change. We found that STAT5B, STAT1, STAT3 DNA-binding activity was induced GM-CSF. also detected activation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway after treatment which inhibited with PI inhibitors, wortmannin LY294002. investigated whether STAT or necessary...
Abstract Purpose: MicroRNAs regulate gene expression by binding to the 3′-untranslated region (UTR) of target genes. Single-nucleotide polymorphisms critical genes may affect their regulation microRNAs. We have identified a single-nucleotide polymorphism within miR-502 seed in 3′-UTR SET8 gene. methylates TP53 and regulates genome stability. investigated role this concert with codon 72 propensity for onset breast cancer. Experimental Design: measured case-control study on 1,110 cancer cases...
Although the role of TNFAIP2 is still unclear, it an important gene involved in apoptosis, and there are single-nucleotide polymorphisms (SNPs) at its microRNA (miRNA)-binding sites that could modulate miRNA target function. In this study, we evaluated associations four selected SNPs (rs8126 T > C, rs710100 G A, rs1052912 A rs1052823 T) miRNA-binding 3′ untranslated region (UTR) with squamous cell carcinoma head neck (SCCHN) risk 1077 patients SCCHN 1073 cancer-free controls a non-Hispanic...
Poly(N,N-diethylacrylamide) is not only a thermosensitive polymer, but also good hydrogen bond acceptor. Therefore, drugs with carboxyl groups can serve as donors and form interactions the tertiary amide in N,N-diethylacrylamide. Herein, we report novel drug delivery system for anionic composed of poly(N,N-diethylacrylamide) salecan. Salecan was used to improve hydrophilicity accelerate responsive rate this system. As expected, salecan-enriched hydrogels exhibited higher swelling ratios were...
An extensive, highly diversified multigene family of novel immune-type receptor ( nitr ) genes has been defined in Danio rerio (zebrafish). The are predicted to encode type I transmembrane glycoproteins consisting extracellular variable (V) and V-like C2 (V/C2) domains, a region cytoplasmic tail. All the examined immunoreceptor tyrosine-based inhibition motifs Radiation hybrid panel mapping analysis deletion mutant line (b240) indicate that minimum ≈40 contiguous genome span ≈0.6 Mb near top...
The novel immune-type receptor (NITR) genes encode a unique multigene family of leukocyte regulatory receptors, which possess an extracellular Ig variable (V) domain and may function in innate immunity. Artificial chromosomes that zebrafish NITRs have been assembled into contig spanning ≈350 kb. Resolution the complete NITR gene cluster has led to identification eight previously undescribed families revealed presence C-type lectins within locus. A maximum haplotype 36 (138 sequences total)...
Abstract Epigenetic changes in chromatin structure have been recently associated with the deregulated expression of critical genes normal and malignant processes. HDAC11, newest member HDAC family enzymes, functions as a negative regulator IL-10 APCs, previously described by our lab. However, at present time, its role other hematopoietic cells, specifically neutrophils, has not fully explored. In this report, for first we novel physiologic HDAC11 multifaceted neutrophils. Thus far, able to...
Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as major obstacle for cancer immunotherapy. The immunoinhibitory activity MDSC is tightly regulated by the tumor microenvironment occurs through mechanistic mediators that remain unclear. Here, we elucidated intrinsic interaction between expression AMP-activated protein kinase alpha (AMPKα) immunoregulatory tumors. AMPKα signaling was increased tumor-MDSC from tumor-bearing mice...
Circular RNAs (circRNAs) have critical regulatory roles in tumor biology. However, their contributions hepatocellular carcinoma (HCC) still remain enigmatic. The present study aimed to investigate the molecular mechanisms underlying involvement of hsa_circ_0110102 occurrence and development HCC. expression level was significantly downregulated HCC cell lines tissues, which associated with poor prognosis. Knockdown promoted proliferation, migration, invasion. Moreover, interaction between...
Tumor heterogeneity dominates tumor biological behavior and shapes the microenvironment. However, mechanisms of genetic features modulate immunity response were not clearly clarified. associated macrophages (TAMs) exert distinct immune functions in progression hepatocellular carcinoma (HCC) based on inducible phenotype. FOXO family members sense changes extracellular or intracellular environment by activating a series signaling pathways. FOXO1, transcription factor that common suppressor...
Abstract Dendritic cells (DC) are involved in the regulation of innate and adaptive immunity. However, molecular mechanisms maintaining DC function remain to be elucidated. In this study, we report on role small Rho GTPases: Cdc42, Rac1, RhoA adherence, Ag presentation, migration, chemotaxis, endocytosis. Murine were transfected with vaccinia virus-based constructs, encoding dominant-negative or constitutively active (ca) mutant forms GTPases. We demonstrate that Cdc42 plays a major...