A5100640261- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Hepatitis C virus research
- Spinal Fractures and Fixation Techniques
- Advanced Radiotherapy Techniques
- Hepatitis B Virus Studies
- Chemokine receptors and signaling
- Immune cells in cancer
- Acute Lymphoblastic Leukemia research
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Scoliosis diagnosis and treatment
Third Affiliated Hospital of Zhengzhou University
2022-2025
Guiyang Medical University
2025
Hangzhou Cancer Hospital
2016-2024
Tianjin Medical University Cancer Institute and Hospital
2013-2023
National Clinical Research
2014-2023
China Academy of Chinese Medical Sciences
2023
Chinese Academy of Sciences
2007-2022
Chengdu Institute of Biology
2015-2022
University of California, San Diego
2019-2021
Xian Yang Central Hospital
2021
Purpose This study aims to develop an optimal machine learning model that uses lung equivalent uniform dose (lung EUD predict radiation pneumonitis (RP) occurrence in cancer patients treated with volumetric modulated arc therapy (VMAT). Methods We analyzed a cohort of 77 diagnosed locally advanced squamous cell (LASCLC) receiving concurrent chemoradiotherapy VMAT. Patients were categorized based on the onset grade II or higher (RP 2+). Dose volume histogram data, extracted from treatment...
Objective The purpose of this study is to investigate the medium- and long-term correction outcomes complications early one-stage posterior-only surgery for congenital cervicothoracic scoliosis in children. Methods From March 2006 2022, we retrospectively investigated 33 consecutive cases treated by surgery, including 15 males 18 females, with a mean age 3.2 years. Radiographic parameters, segmental scoliosis, distal compensatory curve, T1 tilt, clavicle angle, neck coronal balance distance,...
Diffuse large B-cell lymphoma (DLBCL) is the most common hematologic malignancy, however, specific tumor-associated genes and signaling pathways are yet to be deciphered. Differentially expressed (DEGs) were computed based on gene expression profiles from GSE32018, GSE56315, The Cancer Genome Atlas (TCGA) DLBC. Overlapping DEGs then evaluated for ontology (GO), enrichment, DNA methylation, protein-protein interaction (PPI) network analysis as well survival analysis. Seventy-four up-regulated...
The aims of the present study were to elucidate transcript levels DNA methyltransferase (DNMT)1, DNMT3a and DNMT3b by quantitative polymerase chain reaction in patients with primary gastrointestinal diffuse large B‑cell lymphoma (PGI‑DLBCL), determine association their expression clinical parameters prognostic values disease. results revealed that DNMT1 PGI‑DLBCL was significantly higher than healthy controls (P=0.04), while lower (P<0.001 P=0.001, respectively). increased correlated shorter...
Although most patients with acute myeloid leukemia (AML) enter remission after induction chemotherapy, the risk of relapse remains considerable. Therefore, some novel therapeutic strategies are still required. This study found that overexpression CD47 on AML cells was at least twofold more than normal bone marrow (NBM) in 81% (17/21) investigated patients; no had lower expression level compared healthy donors. The also demonstrated blocking CD47/SIRPα (signal regulatory protein α) signal...
AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) patients, explore its associations with patients' clinical parameters. METHODS:Fresh paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute Hospital January 2005 to May 2010 were obtained, 30 lymphoid reactive lymph nodes of age-and sexmatched represented...
To investigate the biological radiation dose-response for patients of limited-stage small-cell lung cancer (LS-SCLC) treated with high dose.Two hundred and five LS-SCLC sequential chemotherapy thoracic radiotherapy involved-field between 1997 2006 were reviewed retrospectively. Biologically effective dose (BED) was calculated homogenization corrected factor overall time. Patients divided into low BED group (n = 70) 135) a cut-off 57 Gy (equivalent to 60 in 30 fractions over 40 days)....
BACKGROUND Acute myeloid leukemia (AML) is associated with a high relapse rate and poor prognosis. This study aimed to use weighted gene coexpression network analysis (WGCNA) of networks identify candidate prognostic biomarker genes in patients AML investigate the expression these human U937 cell line vitro. MATERIAL AND METHODS RNA-seq data were retrieved from Cancer Genome Atlas (TCGA) included bone marrow samples survival (N=151), who did not after treatment (N=119), (N=40)....
The aim of the present study was to evaluate relationship Epstein-Barr virus (EBV) infection and multiple myeloma (MM) its impact on clinical characteristics prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed treated January 2010 May 2018 50 PBMC samples healthy donors were obtained. PCR carried out for detection EBV-DNA. results indicated a significantly higher EBV-DNA concentration among compared with controls (P<0.05). Correlation...
Pan-genotype NS5A inhibitors underpin hugely successful hepatitis C virus (HCV) therapy. The discovery of GSK2818713 (13), a nonstructural protein 5A (NS5A) HCV inhibitor characterized by significantly improved genotype coverage relative to first-generation daclatasvir (DCV), is detailed herein. SAR analysis revealed cooperative potency effects the biphenylene, bicyclic pyrrolidine (Aoc), and methyl-threonine structural motifs. Relative DCV, 13 activity against 1a (gt1a) gt1b variants as...
Abstract Background Concurrent chemo-radiotherapy remains the standard treatment in unresectable stage III non-small-cell lung cancer (NSCLC) patients. Several studies have shown a potential value of concurrent epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) with thoracic radiotherapy EGFR-mutated population, but high risk radiation pneumonitis raised major concern. This study intends to explore safety and efficacy almonertinib, new third-generation EGFR-TKI, locally...
Objective To retrospectively analyze the feasibility and efficacy of posterior hemivertebra resection without internal fixation in treatment congenital scoliosis very young children. Methods Sixteen cases children with treated at our hospital from April 2000 to July 2019 were collected, including 8 each sex, all whom had type I/III operated on a median (interquartile range) 9.00 (7.75) months (range, 0.5–48 months) age. All underwent wore orthopedic braces or plaster undershirts for more...