A5035779120- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Ultrasound and Hyperthermia Applications
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Colorectal and Anal Carcinomas
- Infrared Target Detection Methodologies
- Intraperitoneal and Appendiceal Malignancies
- Astronomy and Astrophysical Research
- Astronomical Observations and Instrumentation
- Glutathione Transferases and Polymorphisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- PI3K/AKT/mTOR signaling in cancer
Hangzhou Cancer Hospital
2017-2025
Zhejiang Chinese Medical University
2018-2025
University of Science and Technology of China
2022-2024
Zhejiang University
2011-2024
Tianjin Medical University Cancer Institute and Hospital
2023
Jiangsu Province Hospital
2023
Hangzhou First People's Hospital
2015-2020
Nanjing Medical University
2015-2020
First Affiliated Hospital of Wenzhou Medical University
2013-2014
Wenzhou Medical University
2013-2014
Although the DNA damage response (DDR) is associated with radioresistance characteristics of lung cancer cells, specific regulators and underlying mechanisms DDR are unclear. Here, we identified serine proteinase inhibitor clade E member 2 (SERPINE2) as a modulator radiosensitivity in cancer. Cells exhibiting after ionizing radiation show upregulation SERPINE2, SERPINE2 knockdown improves tumor vitro vivo. Functionally, deficiency causes reduction homologous recombination repair, rapid...
The aim of this study was to determine the prognostic factors and their significance in gastric cancer (GC) patients, using artificial neural network (ANN) Cox regression hazard (CPH) models. A retrospective analysis undertaken, including 289 patients with GC who had undergone gastrectomy between 2006 2007. According CPH analysis, disease stage, peritoneal dissemination, radical surgery body mass index (BMI) were selected as significant variables. ANN model, surgery, serum CA19-9 levels,...
Analyses of previous data have confirmed the contribution IRF6 gene to susceptibility non- syndromic oral clefts (NSOC) in some populations. We tested for associations between rs2013162, rs2235375, and rs2235371 polymorphisms risk NSOC, using both case-parent trio case-control designs on samples from western China. Our study group consisted 332 persons with their parents (289 mothers 243 fathers 206 complete trios these three SNPs), 174 control individuals. found strong evidence over-...
Objective This study aimed to construct a model for using in differentiating benign and malignant nodules with the artificial neural network increase objective diagnostic accuracy of US. Materials methods 618 consecutive patients (528 women, 161 men) 689 thyroid (425 264 nodules) were enrolled present study. The presence absence each sonographic feature was assessed nodule - shape, margin, echogenicity, internal composition, calcifications, peripheral halo vascularity on color Doppler....
Glasgow prognostic score (GPS), an inflammation-based scoring system, has been evaluated in various cancers. However, its clinical significance remains unclear non-small cell lung cancer (NSCLC). Therefore, it is necessary to conduct a meta-analysis explore the value of GPS NSCLC patients. A quantitative was performed through systematic search PubMed, Web Science, and Cochrane Library. The pooled hazard ratios (HRs) overall survival (OS) were calculated compared. total 12 studies comprising...
Abstract Introduction Plasma circulating tumor DNA (ctDNA) is an ideal approach to detecting the epidermal growth factor receptor ( EGFR ) T790M mutation, which a major mechanism of resistance first‐generation EGFR‐tyrosine kinase inhibitor (TKI) therapy. The present study aimed explore association ctDNA‐identified mutation with disease failure sites and clinical prognosis in non‐small cell lung cancer (NSCLC) patients. Methods Patients who progressed on TKIs were categorized into site...
Approximately 50% of patients harbor the T790M mutation after developing first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance. Evidence has showed major treatment failure is local relapses and limited metastases. Several studies have demonstrated value radiotherapy in metastatic non-small cell lung cancer (NSCLC) with EGFR development TKI The aim this study was to explore role radiation T790M-mutant NSCLC early for T790M-mediated EGFR-TKI
Post-operative microwave (MW) hyperthermia has been applied as an important adjuvant therapy to enhance the efficacy of traditional cancer treatment. A better understanding molecular mechanisms MW may provide guided and further information on clinical In this study, we examined effects non‑small cell lung carcinoma (NSCLC) cells in vitro, well underlying mechanisms. order mimic treatment, developed special heating equipment for study. Various NSCLC (H460, PC-9 H1975) were exposed treatment...
The anti-tumor effects of S-allylcysteine (SAC), a water-soluble garlic derivative, on human ovarian cancer cells have been previous studied in vitro and vivo models but the precise epigenetic molecular mechanisms are still unclear. This study aimed to investigate mechanism SAC. Human epithelial cell line A2780 was selected. Cell proliferation cycle analyzed. DNA methylation, methyltransferase (DNMT) activity, tumor suppressor gene expressions, as well protein expression were SAC could...
In our previous study, stable subpopulations of the A549 lung cancer cell line with high/low invasive potential (H/L‑INV) were obtained. present microarray analysis H/L‑INV was performed to evaluate genes associated high invasiveness. Forkhead box protein A1 (FOXA1) selected for further investigation. The expression levels FOXA1 in primary lesion and metastatic lymph nodes assessed using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis. addition, mRNA examined...
Abstract Background Whole brain radiotherapy (WBRT) can impair patients’ cognitive function. Hippocampal avoidance during WBRT potentially prevent this side effect. However, manually delineating the target area is time-consuming and difficult. Here, we proposed a credible approach of automatic hippocampal delineation based on convolutional neural networks. Methods Referring to hippocampus contouring atlas by RTOG 0933, delineated (MD) MRI data sets (3-dimensional T1-weighted with slice...
Few studies to date have assessed the incidence of radiation pneumonitis (RP) in lung cancer patients who been treated with volumetric modulated arc therapy (VMAT). This study is aimed at reporting RP rate and risk factors associated a symptomatic VMAT.A total 77 consecutive VMAT from 2013 through 2015 were reviewed. severity was graded according Common Terminology Criteria for Adverse Events (CTCEA) v.4. Univariate multivariate analyses performed identify significant RP.VMAT allowed us...
Abstract Background Peritoneal metastasis is the most frequent failure in gastric cancer. This study evaluated role of prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion (CHIP) patients after D2 dissection. Methods Gastric cancer dissection were enrolled this study. Patients received either chemotherapy (IV group) or CHIP (CHIP group). Sites recurrence metastasis, disease-free survival (DFS), overall (OS) and adverse events evaluated. Results Twenty-two treatment, 21 alone....
AZD9291 is a novel, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), which administered orally. It has been proven effective in non-small cell lung cancer (NSCLC) patients, with both EGFR-sensitizing and EGFR T790M mutations preclinical models. However, the potential therapeutic effects of combined other modalities, including ionizing radiation, are not well understood. The presence significantly increases cell-killing radiation PC-9-IR cells secondary...
The prevalence of EGFR mutations in circulating free tumor-derived DNA (ctDNA) was still unknown China. This large-scale study (NCT02623257) aimed to explore the epidermal growth factor receptor (EGFR) and determine correlation mutation status with clinical characteristics.Plasma samples from 1,001 patients stage III/IV NSCLC who received ≤1st line chemotherapy were collected 65 hospitals. tested by amplification refractory system (ARMS) method. rate calculated associations between patients'...