Jianjun Lai

ORCID: 0000-0002-2440-7919
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Research Areas
  • Nanoplatforms for cancer theranostics
  • Advanced Radiotherapy Techniques
  • Radiation Therapy and Dosimetry
  • Lung Cancer Diagnosis and Treatment
  • Ultrasound and Hyperthermia Applications
  • Extracellular vesicles in disease
  • Wireless Body Area Networks
  • Antenna Design and Analysis
  • Cancer, Hypoxia, and Metabolism
  • Neuroendocrine Tumor Research Advances
  • PI3K/AKT/mTOR signaling in cancer
  • Esophageal Cancer Research and Treatment
  • Wireless Power Transfer Systems
  • EEG and Brain-Computer Interfaces
  • 3D Printing in Biomedical Research
  • Lung Cancer Treatments and Mutations
  • RNA Interference and Gene Delivery
  • Photoacoustic and Ultrasonic Imaging
  • Intraperitoneal and Appendiceal Malignancies
  • Cerebrovascular and Carotid Artery Diseases
  • Medical Imaging Techniques and Applications
  • Transcranial Magnetic Stimulation Studies
  • Lanthanide and Transition Metal Complexes
  • Vascular Malformations Diagnosis and Treatment
  • Cancer Mechanisms and Therapy

Zhejiang Hospital
2020-2024

Zhejiang University
2021-2024

Hangzhou Dianzi University
2023-2024

Nanjing Jiangning Hospital
2022

X-ray computed tomography (CT) and magnetic resonance (MR) imaging are essential tools in modern medical diagnosis treatment. However, traditional contrast agents inadequate the of various health conditions. Consequently, development targeted nano-contrast has become a crucial area focus image-enhancing agents. To fully understand current agents, this review provides an overview preparation methods research advancements CT MR CT/MR multimodal described previous publications. Due to...

10.1177/00368504241228076 article EN cc-by-nc Science Progress 2024-01-01

In this paper, a new dual-polarized (DP) omnidirectional hemisphere dielectric resonator antenna (DRA) for wireless capsule endoscope system (WCE) is proposed. The was excited in its TM018 and TE018 modes to radiate DP wave by feeding probe arc microstrip line, respectively. Omnidirectional can be obtained when the mode are equal amplitude phase. that equivalent electric dipole feeding. four lines They provide pair of magnetic dipoles orthogonal mode. DRA fabricated without need feed network...

10.1109/access.2021.3052601 article EN cc-by IEEE Access 2021-01-01

We retrospectively studied the dosimetry and setup accuracy of deep inspiration breath-hold (DIBH) radiotherapy in right-sided breast cancer patients with regional nodal irradiation (RNI) who had completed treatment based on surface-guided (SGRT) technology by Sentinel/Catalyst system, aiming to clarify clinical application value related issues.Dosimetric indicators four organs at risk (OARs), namely heart, right coronary artery (RCA), lung, liver, were compared premise that planning target...

10.1002/acm2.13998 article EN cc-by Journal of Applied Clinical Medical Physics 2023-04-22

Radiotherapy (RT) is the primary treatment for prostate cancer (PCa); however, emergence of castration-resistant (CRPC) often leads to failure and cancer-related deaths. In this study, we aimed explore use microwave hyperthermia (MW-HT) sensitize PCa RT investigate underlying molecular mechanisms.

10.1080/02656736.2024.2335201 article EN cc-by International Journal of Hyperthermia 2024-04-07

Because of the challenges posed by anatomical uncertainties and low resolution plain computed tomography (CT) scans, implementing adaptive radiotherapy (ART) for small hepatocellular carcinoma (sHCC) using artificial intelligence (AI) faces obstacles in tumor identification-alignment automatic segmentation. The current study aims to improve sHCC imaging ART a gold nanoparticle (Au NP)-based CT contrast agent enhance AI-driven automated image processing. synthesized charged Au NPs demonstrated notable

10.1021/acs.nanolett.4c02823 article EN cc-by-nc-nd Nano Letters 2024-07-24

Abstract A wearable flexible tri‐annular square ring monopole antenna with artificial magnetic conductor (AMC) is proposed. The operates at the ISM band (2.28–2.51 GHz, 5.2–6 GHz) and WiMAX (3.5‐4GHz) for wireless body area network (WBAN) applications. number of operating bands determined by rings. tri‐band AMC array integrated to reduce specific absorption rate (SAR) profile. overall size 90 × 6 mm 3 . peak gain 4.8, 5.1, 6.2 dBi three frequency bands, respectively. proposed were printed on...

10.1002/mop.33040 article EN Microwave and Optical Technology Letters 2021-09-06

Abstract Background and purpose By employing three surface‐guided radiotherapy (SGRT)‐assisted positioning methods, we conducted a prospective study of patients undergoing SGRT‐based deep inspiration breath‐hold (DIBH) using Sentine/Catalys system. The aim this was to optimize the initial workflow SGRT‐DIBH for breast cancer. Materials methods A total 124 were divided into groups conduct comparative setup accuracy efficiency daily radiotherapy. Group subjected skin marker plus SGRT...

10.1002/acm2.14319 article EN cc-by Journal of Applied Clinical Medical Physics 2024-03-24

This study pioneered the use of WIRA whole-body infrared hyperthermia combined with ICI therapy to treat GIT and verified feasibility safety HIT. The final results showed a DCR 55.6%, median PFS 53.5 days, OS 134 an irAE incidence 22.2%. Therefore, we believe that HIT can exert multiple synergistic sensitisation effects, thereby providing clinical benefits patients advanced GITs, increasing overall safety, improving patients' QOL.

10.1002/cam4.70024 article EN cc-by Cancer Medicine 2024-07-01

Abstract Background Peritoneal metastasis is the most frequent failure in gastric cancer. This study evaluated role of prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion (CHIP) patients after D2 dissection. Methods Gastric cancer dissection were enrolled this study. Patients received either chemotherapy (IV group) or CHIP (CHIP group). Sites recurrence metastasis, disease-free survival (DFS), overall (OS) and adverse events evaluated. Results Twenty-two treatment, 21 alone....

10.1186/s12885-020-07339-6 article EN cc-by BMC Cancer 2020-08-31

Background: Transcranial direct current stimulation (tDCS) is a non-invasive technique that has demonstrated potential in modulating cortical neuron excitability. The objective of this paper to investigate the effects tDCS on characteristic parameters brain functional networks and muscle synergy, as well explore its for enhancing motor performance. Methods: By applying different durations cortex brain, 32-lead electroencephalogram (EEG) cerebral 4-lead electromyography (EMG) signals right...

10.31083/j.jin2301022 article EN cc-by Journal of Integrative Neuroscience 2024-01-22

Organoids are miniaturized organs cultured in vitro, exhibiting self-renewal and self-organization capabilities. In comparison to traditional 2D cell cultures, organoids can reproduce the spatial structure functionality resembling corresponding tissues or organs, providing highly physiologically relevant vitro systems. Consequently, they be utilized for simulating disease occurrence, testing tumor drug sensitivity co-culturing with other cells. This study aims establish a Patient-Derived...

10.62714/zeqg2556 article EN Deleted Journal 2023-12-21

Objective To compare the irradiated dose to unprotected lymph node stations (LNS) between volume-modulated arc therapy (VMAT) and 5-field intensity-modulated radiotherapy (5F-IMRT) in treatment of patients with upper thoracic esophageal cancer. Methods A total 20 were selected for re-planning. LNS not included GTV CTV, instead, contoured as normal tissues. However, constrained VMAT 5F-IMRT inverse optimization protection. Dosimetric parameters conformal index (CI), homogeneity (HI)...

10.3760/cma.j.issn.0254-5098.2020.01.006 article EN Zhonghua fangshe yixue yu fanghu zazhi 2020-01-25

Abstract Background: This paper studied retrospectively the dosimetry and therapeutic accuracy of deep inspiration breath hold (DIBH) radiotherapy in regional nodal radiation (RNI)-containing right-sided breast cancer patients who had completed treatment based on surface guided (SGRT) technology, hoping to clarify clinical application value related issues . Methods: Free (FB) DIBH plans were prepared for31 RNI-containing right SGRT technology. Four organs at risk (OARs) including heart,...

10.21203/rs.3.rs-2185678/v1 preprint EN cc-by Research Square (Research Square) 2022-10-25

Energy metabolic reprogramming has recently been recognized as an important hallmark of tumor biology, and cells can be manipulated to obtain rapid growth, immune evasion apoptosis, which play role in development. Enhanced glycolysis is the main source energy required for tumorigenesis, development metastasis microenvironment, Warburg suggested that preferentially choose pathway provide even under aerobic conditions, but mechanisms causes this alteration remain unclear. PFKFB3 activator...

10.31579/2690-4861/268 article EN cc-by International Journal of Clinical Case Reports and Reviews 2022-12-07
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