A5101876540- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Virus-based gene therapy research
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Animal Genetics and Reproduction
- Cell death mechanisms and regulation
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- Cancer-related Molecular Pathways
- vaccines and immunoinformatics approaches
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- interferon and immune responses
- NF-κB Signaling Pathways
- Photosynthetic Processes and Mechanisms
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Ginseng Biological Effects and Applications
Fred Hutch Cancer Center
2017-2024
Central South University
2021-2024
Hunan University of Humanities, Science and Technology
2024
Guizhou University
2022-2024
Nanjing Medical University
2023
Yunnan Agricultural University
2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Tobacco Research Institute
2023
Shenzhen Genoimmune Medical Institute
2021-2022
Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth experimental tumors more effectively than conventional therapy or agent alone. present study was designed to evaluate the efficacy gemcitabine combined with ginsenoside Rg3 on angiogenesis established Lewis lung carcinoma in mice.C57L/6 mice implanted were randomized into control, group. quality life survival recorded. Tumor...
Depletion of CD8+ T cells is a major obstacle in immunotherapy; however, the relevant mechanisms remain largely unknown. Here, we showed that prostate cancer (PCa) cell-derived exosomes hamper cell function by transporting interleukin-8 (IL-8). Compared to low IL-8 levels detected immune cells, PCa secreted abundance and further accumulated exosomes. The delivery into exhausted through enhanced starvation. Mechanistically, exosomal overactivated PPARα recipient thereby decreasing glucose...
Abstract Polo-like kinase 3 (Plk3) is an important mediator of the cellular responses to genotoxic stresses. In this study, we examined physiologic function Plk3 by generating Plk3-deficient mice. Plk3−/− mice displayed increase in weight and developed tumors various organs at advanced age. Many were large size, exhibiting enhanced angiogenesis. mouse embryonic fibroblasts hypersensitive induction hypoxia-inducible factor-1α (HIF-1α) under hypoxic conditions or nickel cobalt ion treatments....
Analyses of previous data have confirmed the contribution IRF6 gene to susceptibility non- syndromic oral clefts (NSOC) in some populations. We tested for associations between rs2013162, rs2235375, and rs2235371 polymorphisms risk NSOC, using both case-parent trio case-control designs on samples from western China. Our study group consisted 332 persons with their parents (289 mothers 243 fathers 206 complete trios these three SNPs), 174 control individuals. found strong evidence over-...
Beclin 1 plays an important role in autophagy, differentiation, antiapoptosis and the development progression of cancer. The function expression natural killer T-cell lymphoma is largely unexplored. study aimed to investigate its relationship with prognosis extranodal lymphoma, nasal type (EN KL). protein 65 tumor specimens from patients newly diagnosed EN KL was examined by immunohistochemistry (IH C). clinical significance statistically analyzed. Immunopositivity for found 56 (86.2%)...
Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), a member of the tumor factor family, induces apoptosis in variety cancer cells. However, gastric (GC) cells are insensitive to TRAIL usually. In previous study, we showed that Periplocin could induce GC via activation ERK1/2‐EGR1 pathway. present have shown combination and had greater inhibitory effect on cell viability vitro vivo than or alone. Through upregulating expression DR4 DR5 at transcriptional protein levels, enhanced...
Potassium (K+) is essential for crop growth. Increasing the K+ content can often directly promote improvement of yield and quality. Heterosis plays an important role in genetic leads to gains. We found that tobacco showed significant heterosis, which highly cultivating varieties with high content. However, mechanism by heterosis occurs leaves not clear. In this study, a comprehensive comparative transcriptome sequencing analysis root samples from hybrid G70 × GDH11 its parental inbred lines...
Abstract MSC s have been shown to improve functional and pathological outcome in lung fibrosis. However, low vivo cell engraftment of the transplanted cells limits their overall effectiveness. KGF (also known as FGF ‐7) is a critical mediator pulmonary epithelial repair through stimulation proliferation. role its therapeutic effects not identified. In this study, we investigated effect on preventive hyperoxia‐induced fibrosis neonatal rats. Neonatal rats exposed normoxia or hyperoxia were...
Abstract CircRNA, an essential RNA molecule involved in various biological functions and diseases, often exhibits decreased expression tumor tissues, playing a role as suppressor, suggesting therapeutic potential for cancer. However, current methods promoting circRNA production are limited. This study introduces novel approach enhancing biogenesis, termed (cpRNA). CpRNA is designed to complement the flanking sequences of reverse complementary matches (RCMs) within pre-mRNA, thereby...
Pancreatic ductal adenocarcinoma (PDAC) tumor heterogeneity impedes the development of biomarker assays suitable for early disease detection that would improve patient outcomes. The CA19-9 glycan is currently used as a standalone PDAC. Furthermore, previous studies have shown cancer cells may display aberrant membrane-associated glycans. We therefore hypothesized PDAC cell subpopulations could be distinguished by signatures. multiplexed immunofluorescence combined with pathologist annotation...
BACKGROUND The transcription factors Sp3/Sp1 are expressed in a various types of cancers and BNIP3 is overexpressed prostate cancer. Although it has been demonstrated that transcriptionally regulated by HIF-1α post-transcriptionally miR145, our previous data indicated there might be some other regulating This study conducted to investigate whether expression directly or not. MATERIALS AND METHODS Bioinformatics analysis shows promoter contains several potential binding sites. And then SP3...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor factor superfamily that induces apoptosis in broad range human cancer cell lines while sparing most normal types. However, many tumors remain resistant to treatment with TRAIL. In this study, we investigated synergistic effects low-dose irinotecan (CPT-11) and TRAIL on TRAIL‑resistant HT-29 colon carcinoma cells explored potential mechanisms apoptosis. Cell viability was analyzed by sulforhodamine B...
Although database search tools originally developed for shotgun proteome have been widely used in immunopeptidomic mass spectrometry identifications, they reported to achieve undesirably low sensitivities or high false positive rates as a result of the hugely inflated space caused by lack specific enzymic digestions immunopeptidome. To overcome such problem, we motif-guided immunopeptidome building tool named IntroSpect, which is designed first learn peptide motifs from confidence hits...