A5076924443- Phytochemistry and Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Phytochemical Studies and Bioactivities
- Cancer Mechanisms and Therapy
- Helicobacter pylori-related gastroenterology studies
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
Hebei Medical University
2019-2024
Fourth Hospital of Hebei Medical University
2019-2024
Esophageal cancer is one of the most common malignant tumors in world. With currently available therapies, only 20% ~ 30% patients can survive this disease for more than 5 years. TRAIL, a natural ligand death receptors that induce apoptosis cells, has been explored as therapeutic agent cancers, but it reported many cells are resistant to limiting potential clinical use TRAIL therapy. Meanwhile, Periplocin (CPP), compound from dry root Periploca sepium Bge, studied its anti-cancer activity...
Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal cancer (EC) in China, and demonstrates varying levels resistance to multiple chemotherapeutic agents. Our previous studies have proved that periplocin (CPP), derived from extract cortex periplocae, exhibiting capacity hinder proliferation induce apoptosis ESCC cells. Several identified additional anti-cancer constituents named periplcymarin (PPM), sharing similar compound structure with CPP....
Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), a member of the tumor factor family, induces apoptosis in variety cancer cells. However, gastric (GC) cells are insensitive to TRAIL usually. In previous study, we showed that Periplocin could induce GC via activation ERK1/2‐EGR1 pathway. present have shown combination and had greater inhibitory effect on cell viability vitro vivo than or alone. Through upregulating expression DR4 DR5 at transcriptional protein levels, enhanced...
Acinetobacter baumannii is a multidrug-resistant coccobacillus responsible for severe nosocomial infectious diseases. This study mainly focuses on investigating the antimicrobial resistance features of clinically isolated strain (A. CYZ) using PacBio Sequel II sequencing platform. The chromosomal size A. CYZ 3,960,760 bp, which contains total 3803 genes with G + C content 39.06%. Functional analysis performed Clusters Orthologous Groups Proteins (COGs), Gene Ontology (GO), Kyoto Encyclopedia...
Background: Esophageal cancer is one of the most common malignant tumors in world. With currently available therapies, only 20% ~30% patients can survive this disease for more than 5 years. Although TRAIL, a natural ligand death receptors that induce apoptosis cells, has been explored as therapeutic agent cancers, it reported many cells are resistant to limiting potential clinical use TRAIL therapy. Meanwhile, Periplocin (CPP), compound from dry root Periploca sepium Bge, studied its...