Wang Chang-le

ORCID: 0000-0001-8559-7923
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About
Contact & Profiles
Research Areas
  • Higher Education and Teaching Methods
  • Legionella and Acanthamoeba research
  • Higher Education Governance and Development
  • Ideological and Political Education
  • Bacterial biofilms and quorum sensing
  • Educational Innovations and Challenges
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Biosensors and Analytical Detection
  • Education and Critical Thinking Development
  • SARS-CoV-2 and COVID-19 Research
  • Educational Challenges and Innovations
  • Long-Term Effects of COVID-19
  • Education and Work Dynamics
  • Vibrio bacteria research studies
  • Educational Methods and Teacher Development
  • Antifungal resistance and susceptibility
  • Antibiotic Resistance in Bacteria
  • Vagus Nerve Stimulation Research
  • Herpesvirus Infections and Treatments
  • Educational Reforms and Innovations
  • Service-Learning and Community Engagement
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Infections and bacterial resistance
  • Poxvirus research and outbreaks
  • Oral and gingival health research

Hebei Medical University
2018-2025

Kyushu University
2012-2016

Guizhou University
2014

Shenzhen University
2012

Jiangsu University
2003-2012

Jiangsu Second Normal University
2006

The gut microbiota (GM) is recognized as a critical factor in sustaining overall health and regulating the immune system. However, precise function of GM pathogenesis bacterial pneumonia (BP), well potential involvement cells these mechanisms, remains inadequately understood. Given that BP represents substantial public issue, elucidating protective role against this condition considerable significance. We employed bidirectional two-sample univariate Mendelian randomization (UVMR) approach to...

10.1186/s12879-025-10758-0 article EN cc-by BMC Infectious Diseases 2025-03-18

Stenotrophomonas maltophilia is an important multidrug-resistant pathogen that associated with various serious nosocomial infections. In our study, we investigated the antimicrobial resistance traits of clinical S. strain CYZ isolated from sputum immunocompromised patient. The whole genome sequence was using a PacBio RS II system. functions all predicted genes were annotated by COG, GO and KEGG databases. Several types antibiotics selected to test susceptibility, phylogenetic tree...

10.1016/j.jgar.2020.09.008 article EN cc-by-nc-nd Journal of Global Antimicrobial Resistance 2020-10-01

Legionella oakridgensis occasionally causes pneumonia in humans. We report here the characteristic morphology of intracellular microcolonies L. OR-10 infected epithelial cells. By light microscopy after Gimenez staining, bacteria showed serpentine-like chain, disk-like conglomerate, and granular forms when they grew intracellularly Vero cells, HeLa A549 In a time-lapse study, we observed progressive change from chain form to conglomerate Transmission electron that proliferated both inside...

10.1139/w11-126 article EN Canadian Journal of Microbiology 2012-01-31

Legionella feeleii is a Gram-negative pathogenic bacterium that causes Pontiac fever and pneumonia in humans. When L. serogroup 1 (ATCC 35072) was cultured on BCYE agar plates, two types of colonies were observed exhibited differences color, opacity morphology. Since the colony are white rugose brown translucent, they termed as (WRLf) translucent (BTLf), respectively. They different growth capacities BYE broth vitro, it found WRLf could transform to BTLf. Under electron microscope, secreted...

10.1093/femsle/fnw098 article EN FEMS Microbiology Letters 2016-04-15

Sensing of bacteria is attracting a great deal interest to avoid an outbreak bacterial infection [1, 2]. The sensors used for this purpose should integrate at least two functions in small volume: trapping and detecting them such as by photo detector on chip, schematically illustrated Fig. 1. We successfully devised microfluidic chip with Si-pillar structure Legionella pneumophila ( L. ) that widely known one pathogenic bacterium confirmed its effectiveness observing fluorescence produced the...

10.1149/ma2014-01/40/1485 article EN Meeting abstracts/Meeting abstracts (Electrochemical Society. CD-ROM) 2014-04-01

Acinetobacter baumannii is a multidrug-resistant coccobacillus responsible for severe nosocomial infectious diseases. This study mainly focuses on investigating the antimicrobial resistance features of clinically isolated strain (A. CYZ) using PacBio Sequel II sequencing platform. The chromosomal size A. CYZ 3,960,760 bp, which contains total 3803 genes with G + C content 39.06%. Functional analysis performed Clusters Orthologous Groups Proteins (COGs), Gene Ontology (GO), Kyoto Encyclopedia...

10.1111/1348-0421.13087 article EN Microbiology and Immunology 2023-07-04
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