A5007325863- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Phytochemistry and Bioactive Compounds
- RNA Research and Splicing
- Toxin Mechanisms and Immunotoxins
- Bioactive Compounds and Antitumor Agents
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Phytochemical compounds biological activities
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
Fourth Hospital of Hebei Medical University
2016-2025
Hebei Medical University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Hospital of Hebei Province
2024
Gene Therapy Laboratory
2023-2024
Cancer Institute (WIA)
2023
Nankai University
2023
Oregon Health & Science University
2023
Art Research Centre of the Slovak Academy of Sciences
2016
First Affiliated Hospital of Hebei Medical University
2011
Long noncoding RNAs (lncRNAs) are emerging as important regulators in cellular processes, including the development, proliferation, and migration of cancer cells. We have demonstrated a prior study that small nucleolar RNA host gene 5 (SNHG5) is dysregulated gastric (GC). To further explore underlying mechanisms SNGH5 function development GC, this study, we screened microRNAs interacting with SNHG5 elucidated their roles GC. showed contains putative miR-32-binding site deletion abolishes...
Extracellular vesicles (EVs), known as cell-derived membranous structures harboring a variety of biomolecules, have been widely used in liquid biopsy. Due to the complex biological composition plasma, plasma RNA omics analysis (RNomics) is easily affected, thus it necessary select an optimal strategy from exiting methods according performance for intended application.In this study, four different strategies EVs isolation were performed and compared (i.e. ultracentrifugation (UC), size...
Gastric cancer (GC) is one of the most prevalent malignant tumors digestive system. As a hallmark cancer, energy-related metabolic reprogramming manipulated by multiple factors, including long non-coding RNAs (lncRNAs). Notably, lncRNA CCAT1 has been identified as crucial regulator in tumor progression. Nevertheless, precise molecular mechanisms underlying involvement GC remain unclear. Gain- and loss-of-function experiments were performed to evaluate roles tumorigenesis glycolysis GC....
Immune checkpoint blockade (ICB) therapy, targeting programmed cell death ligand-1 (PD-L1)/programmed protein 1 (PD-1) axis and cytotoxic T-lymphocyte-associated 4 (CTLA-4), has exhibited amazing clinical outcomes in various types of cancers. However, only a small portion patients benefit from ICB indicating that the mechanism underlying immune is still unclear. Here, it reported motor neuron pancreas homeobox (MNX1), domain-containing transcription factor, contributes to tumor escape. MNX1...
Abstract Tumor-associated macrophages (TAMs) play critical roles in promoting tumor progression and invasion. However, the molecular mechanisms underlying TAM regulation remain to be further investigated may make significant contributions cancer treatment. Mammalian microRNAs (miRNAs) have recently been identified as important regulators of gene expression that function by repressing specific target genes mainly at post-transcriptional level. systematic studies functions miRNAs TAMs tissues...
Chronic infections can lead to carcinogenesis through inflammation-related mechanisms. infection of the human gastric mucosa with Helicobacter pylori is a well-known risk factor for cancer. However, mechanisms underlying H. pylori–induced are incompletely defined. We aimed screen and clarify functions long noncoding RNAs (lncRNAs) that differentially expressed in pylori–related found lncRNA SNHG17 was upregulated by markedly increased levels double-strand breaks (DSBs). overexpression...
Abstract Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the detailed mechanisms by which tumor cells evade premature to malignant progression remain largely elusive. Here we reported that RBM4 adversely impacted cellular favor glutamine-dependent survival of esophageal squamous cell carcinoma (ESCC) dictating activity LKB1, critical governor cancer metabolism. The level was specifically elevated ESCC...
Abstract Objective This study determined the expression of microRNA‐1 in esophageal squamous cell carcinoma (ESCC) tissue and lines to evaluate its effects on clinicopathological parameters target genes LASP1 TAGLN2. Methods The miR‐1, lasp1, tagln2 was detected 55 ESCC tissues adjacent normal by reverse transcription–polymerase chain reaction (RT‐PCR). association between characteristics observed. MicroRNA‐1 (mimics‐miR‐1) inhibitor (Inhibitor‐miR‐1) were transfected into cancer cells KYSE...
Long noncoding RNAs (lncRNAs) participate in and regulate the biological process of colorectal cancer (CRC) progression. Our previous research identified differentially expressed lncRNAs 10 CRC tissues matched nontumor by next-generation sequencing (NGS). In this study, we an lncRNA, FEZF1 antisense RNA 1 (FEZF1-AS1), further explored its function mechanism CRC. We verified that FEZF1-AS1 is highly cell lines. Through functional experiments, found reduced levels significantly suppressed...
Abstract Transcobalamin (TCN1) is a vitamin B12 (cobalamin)-binding protein that regulates cobalamin homeostasis. Recent studies and bioinformatic analyses have found TCN1 highly expressed in cancer tissues associated with tumour aggressiveness poor prognosis. The present study aimed to detect as novel biomarker for prognosis chemosensitivity of colon cancer. Next-generation sequencing showed was one several upregulated mRNAs cancer, which verified by further bioinformatics analyses. Western...
Abstract Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible for symmetric dimethylation of (SDMA), and plays predominantly roles in human cancers, including ovarian cancer. However, the exactly underlying mechanisms PRMT5 contributing to progression cancer mediated by reprogramming cell metabolism remain largely elusive. Here, we report that highly expressed correlates with poor survival Knockdown or pharmaceutical inhibition sufficient decrease glycolysis...
Tumor metastasis occurs in hepatocellular carcinoma (HCC), leading to tumor progression and therapeutic failure. Anoikis is a matrix detachment-induced apoptosis, also known as cell death, mechanistically prevents cells from escaping their native extracellular metastasize new organs. Deciphering the regulators mechanisms of anoikis cancer urgently needed treat HCC. Several natural synthetic products induce HCC vivo models. Here, we first briefly summarize current understanding molecular...
Long noncoding RNAs (lncRNAs) play an important role in gene regulation, but their impact on the pathogenesis of colorectal cancer and biological function cells is unclear. In this study, we used next-generation sequencing to study differences expression profiles lncRNAs mRNAs tissues. We analyzed differentially expressed genes by Gene Ontology/Kyoto Encyclopedia Genes Genomes (GO/KEGG) enrichment predicted new lncRNA functions. Our results revealed that compared with nontumor tissues, 1019...
B7‐H4, one of the costimulatory molecules B7 family, has been found to be widely expressed in many kinds tumor tissues and play an important part progression poor prognosis. However, role B7‐H4 esophageal squamous cell carcinoma ( ESCC ) cells not elucidated. In this study, we that, compared with normal tissue, was highly three lines, Eca109, TE 1, 13. silenced suppressed cellular proliferation colony formation. Additionally, control cells, showed higher apoptosis rates, Bcl‐2 Survivin...
Periplocin is extracted from the traditional herbal medicine cortex periplocae, which has been reported to suppress growth of cancer cells. However, little known about its effect on gastric cells.Gastric cells were treated with periplocin, and cell viability was assessed using MTS assay. Flow cytometry TUNEL staining performed evaluate apoptosis, protein expression examined by western blotting. Microarray analysis used screen for changes in related genes.We found that periplocin had an...
Resistance to chemotherapy drugs, such as adriamycin (ADR), is a common problem in acute myeloid leukemia (AML) patients. We hypothesized that the natural compound resveratrol (Res) may reverse AML drug resistance through PI3K/Akt/Nrf2 pathway. investigated vitro effect of Res using human promyelocytic cells (HL-60) and ADR-resistant cell line (HL-60/ADR) treated with either or ADR + Res. Cellular proliferation inhibition rate, auto-fluorescence intensity HL-60/ADR HL-60 cells, mRNA...
Stomach adenocarcinoma (STAD), which accounts for approximately 95% of gastric cancer types, is a malignancy with high morbidity and mortality. Tumor angiogenesis plays important roles in the progression pathogenesis STAD, long noncoding RNAs (lncRNAs) have been verified to be crucial angiogenesis. Our study sought construct prognostic signature angiogenesis-related lncRNAs (ARLncs) accurately predict survival time STAD.The RNA-sequencing dataset corresponding clinical data STAD were...
Interleukins are assumed to be closely related the occurrence and development of human malignant tumors, while a few them were commonly used as diagnostic markers in clinical cancer, including lung cancer. This study aimed explore value serum interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) combined with carcinoembryonic antigen (CEA) biomarker panel for diagnosis metastasis prediction IL-1β, IL-6, IL-8, CEA determined using electrochemiluminescence immunoassay (ECLIA) flow...