A5087072812- Diet and metabolism studies
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer therapeutics and mechanisms
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
Soochow University
2024-2025
Immune checkpoint blockade (ICB) therapy, targeting programmed cell death ligand-1 (PD-L1)/programmed protein 1 (PD-1) axis and cytotoxic T-lymphocyte-associated 4 (CTLA-4), has exhibited amazing clinical outcomes in various types of cancers. However, only a small portion patients benefit from ICB indicating that the mechanism underlying immune is still unclear. Here, it reported motor neuron pancreas homeobox (MNX1), domain-containing transcription factor, contributes to tumor escape. MNX1...
<p>S3. In AOM/DSS model mice, antibiotic treatment significantly attenuated the colon tumorigenesis.</p>
<p>S8. IHC staining of NRF2 in the normal BCAA diet group and low group.</p>
<p>Figure S7. Mass spectrometry analysis of the BCAT2, keratin 19 and ACOT7 peptides pulled down by antisense circ_0126925 probes.</p>
<div>Abstract<p>Recent evidence indicates that a high-fat diet can promote tumor development, especially colorectal cancer, by influencing the microbiota. Regulatory circular RNA (circRNA) plays an important role in modulating host–microbe interactions; however, specific mechanisms which circRNAs influence cancer progression regulating these interactions remain unclear. Here, we report consumption of modulates microbiota specifically upregulating expression noncoding...
<p>S4. HFD-modulated gut microbiota of mice and obese patients promote malignant progression colorectal tumors in Abx pretreated AOM/DSS model mice.</p>
<p>S5. <i>In vitro</i>, circ_38945 promotes proliferation and migration.</p>
<p>S6. Stable cells with circ_0126925 knockdown or overexpression.</p>
<p>S2. IF of the tight junction proteins ZO-1 and Occludin in AOM/DSS model mice subjected to three different treatment methods IHC staining Ki-67 colon two methods.</p>
<p>S1. Representative images of colon length and rectal bleeding at the endpoint modelling in AOM/DSS model mice subjected to three different treatment methods.</p>
Abstract Recent evidence indicates that a high-fat diet can promote tumor development, especially colorectal cancer, by influencing the microbiota. Regulatory circular RNA (circRNA) plays an important role in modulating host–microbe interactions; however, specific mechanisms which circRNAs influence cancer progression regulating these interactions remain unclear. Here, we report consumption of modulates microbiota specifically upregulating expression noncoding hsa_circ_0126925 (herein,...