A5102847382- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Genetic Neurodegenerative Diseases
- Circular RNAs in diseases
Dalian Medical University
2025
Peking University
2022-2024
Peking University Cancer Hospital
2022-2024
Wenzhou Medical University
2014
Abstract Circular RNAs (circRNAs) were shown to play an important role in the occurrence and progression of tumors. However, functions nuclear genome-derived circRNAs localized mitochondria tumor cells remain largely elusive. Here, we report that circPUM1, a circular RNA derived from back-splicing pre-mRNAs genome PUM1, localizes mitochondria. The expression level circPUM1 is positively correlated with HIF1α accumulation under CoCl 2 -induced intracellular hypoxic-like condition esophageal...
Abstract Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell carcinoma (ESCC). We discover cyclin-dependent kinase 7 (CDK7) phosphorylates nuclear Yes-associated protein 1 (YAP) at S127 and S397 sites enhances its transcription function, which promotes dehydrogenase (LDHD) expression. Moreover, LDHD enriched...
Immune checkpoint blockade (ICB) therapy, targeting programmed cell death ligand-1 (PD-L1)/programmed protein 1 (PD-1) axis and cytotoxic T-lymphocyte-associated 4 (CTLA-4), has exhibited amazing clinical outcomes in various types of cancers. However, only a small portion patients benefit from ICB indicating that the mechanism underlying immune is still unclear. Here, it reported motor neuron pancreas homeobox (MNX1), domain-containing transcription factor, contributes to tumor escape. MNX1...
Abstract Background In addition to functioning as a precise monitoring mechanism in cell cycle, the anaphase-promoting complex/cyclosome (APC/C) is reported be involved regulating multiple metabolic processes by facilitating ubiquitin-mediated degradation of key enzymes. Fatty acid oxidation pathway utilized tumor cells that crucial for malignant progression; however, its association with APC/C remains explored. Methods Cell cycle synchronization, immunoblotting, and propidium iodide...
Esophageal cancers are primarily categorized as esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). While various (epi) genomic alterations associated with tumor development in ESCC EAC have been documented, a comprehensive comparison of the transcriptomes these two cancer subtypes remains lacking.We collected 551 gene expression profiles from publicly available sources, including normal, ESCC, tissues or lines. Subsequently, we conducted systematic analysis to compare...
Autosomal dominant optic atrophy (ADOA) is the most frequent form of hereditary neuropathy and occurs due to degeneration retinal ganglion cells. To identify genetic defect in a family with putative ADOA, we performed capture next generation sequencing (CNGS) screen known disease genes. However, six exons failed be sequenced by CNGS 1 gene (OPA1). Sequencing those identified 4 bp deletion mutation (c.2983-1_2985del) OPA1. Furthermore, transcripts OPA1 from patient skin fibroblasts found...