A5073707720- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Cancer Mechanisms and Therapy
- Telomeres, Telomerase, and Senescence
- Hippo pathway signaling and YAP/TAZ
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Cancer Research and Treatments
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Reconstructive Facial Surgery Techniques
- Liver physiology and pathology
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Dermatologic Treatments and Research
- Cerebrovascular and genetic disorders
- Laser Applications in Dentistry and Medicine
- Retinal Development and Disorders
- FOXO transcription factor regulation
- Inflammasome and immune disorders
Peking University
2019-2025
Peking University Cancer Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guiyang Medical University
2024
First Hospital of China Medical University
2018-2023
China Medical University
2013-2023
Southwest University
2023
ORCID
2020
Abstract Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell carcinoma (ESCC). We discover cyclin-dependent kinase 7 (CDK7) phosphorylates nuclear Yes-associated protein 1 (YAP) at S127 and S397 sites enhances its transcription function, which promotes dehydrogenase (LDHD) expression. Moreover, LDHD enriched...
Tissues undergo a process of degeneration as the body ages. Mesenchymal stem cells (MSCs) have been found to major potential in delaying aging tissues and organs. However, mechanism underlying anti-aging effects MSC is not clear which limits clinical applications. In this study, we used adipose-derived mesenchymal (ADSCs) perform treatments on senescent progeroid animal models. Following intervention with ADSCs, replicative senescence was delayed metabolic homeostasis transformed from...
Abstract Background Human adipose-derived stem cells (hADSCs) are with the potential to differentiate in multiple directions. miR-204-5p is expressed at low levels during osteogenic differentiation of hADSCs, and its specific regulatory mechanism remains unclear. Here, we aimed explore function possible molecular hADSCs. Methods The expression patterns miR-204-5p, Runx2 , alkaline phosphatase ( ALP ), osteocalcin OCN forkhead box C1 FOXC1 ) growth factor 7 GDF7 hADSCs osteogenesis were...
Biliary epithelial cells (BECs) are a potential source to repair the damaged liver when hepatocyte proliferation is compromised. Promotion of BEC-to-hepatocyte transdifferentiation could be beneficial clinical therapeutics patients with end-stage diseases. However, mechanisms underlying initiation BEC remain largely unknown. Here, we show that upon extreme injury, vegfaa and vegfr2/kdrl notably induced in hepatic stellate BECs, respectively. Pharmacological genetic inactivation vascular...
Progerin, a product of LMNA mutation, leads to multiple nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), devastating premature aging disorder. Progerin also accumulates during physiological aging. Here, we demonstrate that impaired insulin-like growth factor 1 receptor (IGF-1R)/Akt signaling pathway results severe retardation and Zmpste24-/- mice, mouse model progeria. Mechanistically, progerin mislocalizes outside the nucleus, interacts IGF-1R,...
The mechanism that maintains ER-to-Golgi vesicles formation and transport is complicated.As one of the adapters, Ninein-like protein (Nlp) participated in assembly transporting partial contained specific proteins, such as β-Catenin STING.Nlp acted a platform to sustain specificity continuity cargoes during COPII COPI-coated vesicle transition transportation through binding directly with SEC31A well Rab1B.Thus, we proposed an integrated model particular adapter cargo selection or cooperating...
Accumulating evidence has shown that the traits of tumor-initiating cells (TICs) are controlled by microenvironment niches (MENs), but composition and remodeling mechanisms MENs TICs poorly defined. Here, we report voltage-gated calcium channel α2δ1 subunit-positive hepatocellular carcinoma (HCC) specifically secret lysyl oxidase (LOX), which leads to cross-linking collagen, forming a stiff extracellular matrix (ECM) is sufficient drive formation with mechanical trait subsequently required...
Advanced gastric cancer (AGC) is a disease with poor prognosis due to the current lack of effective therapeutic strategies. Immune checkpoint blockade treatments have shown responses in patient subgroups but biomarkers remain challenging. Traditional classification (GC) based on genomic profiling and molecular features. Therefore, it critical identify immune-related subtypes predictive markers by immuno-genomic profiling.Single-sample gene-set enrichment analysis (ssGSEA) ESTIMATE algorithm...
The metastatic cascade, a multifaceted and highly aggressive process, is the primary cause of mortality. survival quiescent cancer cells in circulatory system during metastasis crucial, yet our comprehension constrained by absence universally accepted models.
Gastric cancer (GC) is the fifth most frequently diagnosed and third leading cause of cancer-related death. There a critical need for development novel therapies in GC. DNA polymerase gamma (PolG) has been implicated mitochondrial homeostasis affects numerous types cancer, however, its effects on GC molecular mechanisms remain to be fully determined. The aim present research was clarify PolG possible mechanism action.The GSE62254 dataset used predict effect prognostic value patients....
BACKGROUND:Hypertrophic scar is associated with excessive proliferation of fibroblasts, the accumulation collagen fibers, and angiogenesis chronic inflammation. Scar resection, combined radiotherapy, widely used in clinical practice, but timing remains controversial. This study aimed to investigate association between postoperative radiotherapy effects on hypertrophic a rabbit model. MATERIAL AND METHODS:Forty New Zealand white rabbits, 8–12 months old, weighing 1.8–2.3 kg were model...
Mesenchymal stem cells (MSCs) possess the ability to self-renew and differentiate into multiple cell types, making them highly suitable for use as seed in tissue engineering. These can be derived from various sources have been found play crucial roles several physiological processes, such repair, immune regulation, intercellular communication. However, limited capacity proliferation secretion of senescence-associated secreted phenotypes (SASPs) pose challenges clinical application MSCs. In...
Scar treatments are considered a major issue in the plastic surgery field. Activation of transforming growth factor-β (TGF-β)-mediated signaling pathway plays key role scar pathogeneses, and high temperature requirement factor A1 (HTRA1) inhibits TGF-β1 activation tumor cells. Our study aims to investigate HTRA1 pathogenesis scars. The mRNA levels was evaluated by real time PCR, protein expression determined using western blot immunohistochemistry, luciferase assay applied measure dynamic...
Abstract Background Facial features vary in size and proportions between different races. This study aimed to measure the anthropometric variables of labial region Han Chinese young adults. Materials Methods A total 900 college students (475 male 425 female) ethnicity from northern China were included. Measurements included 14 linear items seven proportions. Results All measurements males significantly higher than those females (all P < 0.001). Significant gender differences found...
Background: Rhinophyma is a rare disease characterized by chronic inflammation and hypertrophy of sebaceous glands, blood vessels, fibrous tissue, associated with end-stage severe acne rosacea. There are multiple approaches to treatment repair, including dermal shaving, secondary intention healing, free skin graft, flaps. However, these methods have various disadvantages, such as prolonged obvious scarring, texture mismatch. Therefore, the authors adopted surgical excision bilateral pedicled...
Abstract Background: Gastric cancer (GC) is the fifth most frequently diagnosed and third leading cause of death. There a critical need for development novel therapies in GC. DNA polymerase gamma (PolG) has been implicated mitochondrial homeostasis affects numerous types. However, its effects GC molecular mechanisms remain to be fully determined. Methods: GSE62254 dataset was used predict impact PolG on prognostic valule patients. Lentivirus-mediated transduction silence expression. Western...